The University of York (UOY) • Biology
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Modules Biology at The University of York (UOY)
Notes available for the following courses of Biology at The University of York (UOY)
Latest notes & summaries The University of York (UOY) • Biology
- To describe the changes in DNA methylation that occur upon fertilization and during early mammalian development and some of the mechanisms involved
- To understand that TET proteins are involved in active demethylation
- To provide an example of how the epigenome can change post-embryonic development 
- To have been reminded of the method of Chromatin Immunoprecipitation and introduced to Bisulfite Sequencing
- To have gained an understanding of why epigenetics is relevant to development
- To understand that DNA methylation can impact gene expression and be able to describe an experimental approach to test this
- To explain how patterns of DNA methylation can be maintained through DNA replication
- To understand that covalent histone modifications form a code that can impact gene expression
- To explain how some histone modifications can be maintained through DNA replication
- Explain the significance of the neural crest lineage to vertebrate anatomy.
- Distinguish the ventral-lateral and dorsal pathways of neural crest migration.
- Give examples of cell types derived from specific AP regions of neural crest. 
- Describe and interpret experiments used to ‘fate map’ neural crest cells in avian embryos.
- Describe and interpret experiments used to determine the developmental potential of neural crest cells in avian embryos.
- Describe the experimental evidence supporting a conserved pathway for regulating neurogenesis in animals
- Discuss the conserved function of proneural genes in neurogenesis
- Discuss the conserved function of neurogenic genes in neurogenesis
- Describe the role of lateral inhibition in selecting neural precursors
- Describe the conserved role of notch-delta signalling in mediating lateral inhibition
- Appreciate and discuss the distinct processes of neural induction, neurogenesis and neurulati...
-Describe and interpret the embryological experiments that demonstrated a role for the notochord and floorplate in motor neuron induction.
-Describe and interpret the experiments that show Shh acts as a morphogen to pattern the ventral neural tube. 
-Be able to explain the concept of morphogen using examples.
-Describe the Shh signal transduction pathway.
Total review on homeostasis with pictures and diagrams