Some examples from this set of practice questions
1.
Why is the logarithm of the drug concentration used?
Answer: Because unlogged values produce a rectangular hyperbola which is difficult to assess
2.
What part of the concentration-response curve is easily comparable?
Answer: The linear portion
3.
What does \'in vitro\' mean?
Answer: That the experiment takes place in a test tube/ laboratory
4.
What does \'ex vivo\' mean?
Answer: When you treat an animal with a drug inside the body (in vivo) then remove that tissue or organ and examine it outside the body (in vitro)
5.
What are two advantages of \'in vitro\' experimentation?
Answer: There are no confounding variables and it is relatively simple
6.
What unit of concentration is used for \'in vitro\' experiments?
Answer: Moles per litre (Molar)
7.
How many molecules of drug are in 1 mole?
Answer: 6.02 x 10^23
8.
What does a concentration of 1 Molar mean?
Answer: That there is 1 mole of drug in 1 litre of solvent
9.
What concentration are most drugs given between?
Answer: 1 x 10^-6 and 1 x 10^-12 M
10.
How could you produce a log concentration-response curve?
Answer: Measure contractions of tissue when a drug is added e.g. guinea pig ileum. Can add different concentrations of drug then wash off and measure contraction, or don\'t wash off and get a cumulative result.
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