Vdj recombination Study guides, Revision notes & Summaries

BIOL 537 EXAM 3 QUIZ and PAPER QUESTIONS AND ANSWERS What does an antibody look like? What part determines antigen specificity? - ANSHeavy chain, light chain, disulfide bonds in Y-shape; binding sites at tip have antigen specificity What is the B cell receptor? - ANS-Membrane bound IgM Which steps in antibody generation is controlled by alternative splicing? A) VDJ recombination B) changing from membrane bound to secrete IgM C) class switching D) affinity maturation - ANS-B) chang...

1. B lymphocytes are made in the: A. blood stream. B. bone marrow. C. liver. D. thymus. E. totipotent cell. -answer Answer: B Section: Introduction Difficulty: 1 Hint: Location of B cell production from a HSC. 2. How long does B cell maturation from an HSC to a mature B cell take? A. 1 to 2 hours B. 1 to 2 days C. 1 to 2 weeks D. 1 to 2 months E. 1 to 2 years -answer Answer: C Section: Introduction Difficulty: 1 Hint: B cell will begin to secrete antibodies within a few da...

Which of the following statements is NOT correct? A.) Sites where PRRs can be expressed include the cell surface, within endosomes, in the cytoplasm, and as secreted molecules that circulate the blood B.) DAMPs are released when host cells undergo necrosis C.) TLRs are a type of PRR that is expressed by all cells of the body D.) Signaling adaptors lead to the activation of different cellular responses after recognition of PAMPs by PRRs E.) PAMPs and DAMPs both alert the immune system t...

This document provides a comprehensive overview of both innate and adaptive immune responses. It details the different cell types involved in innate immunity, the components and mechanisms of pathogen recognition, and the role of key receptors and transcription factors. The document also contrasts the innate and adaptive immune systems, explaining the structure and function of antibodies, the process of V(D)J recombination, and the factors contributing to antibody diversity. Additionally, it cov...

How the 3D arrangement of the genome in the nucleus and non-coding transcription facilitate VDJ recombination

Lecture of LIFE305 Cell Signalling on immune cell signalling. Covers B-cell development, different types of B cells, V(D)J recombination (in-depth mechanism/overview), class-switch recombination, different classes of immunoglobulins (Igs), different models of B-cell activation (dissociation activation model and crosslinking model), detailed overview of B cell receptor signalling (Syk/Lyn kinase, src-family kinases, protein tyrosine phosphatases), models of proximal BCR signalling (conformational...