Molecular and Celluar Biology

Revision notes for Cancer Biology covering control of the cell cycle, molecular mechanisms (CDK and Cyclins), cell cycle checkpoints, response to DNA damage. Introduction to oncogenes and tumor suppressors and how various mechanisms link to the hallmarks of cancer.

Overview of blood cancers/leukaemia covers the main four - ALL, AML, CLL, CML. Description of haematopoesis and the stages that leukemia occurs. Overview of CML and the Philadelphia chromosome.

Overview of various genetic techniques spanning a range of applications such as cytogenetics, cancer, rare disease. Covers the different uses of PCR, arrays, NGS and the advantages and disadvantages of each.

Overview of down syndrome, cystic fibrosis and DYPD case studies. Discussion of genotype and phenotype, treatment options, diagnosis and prognosis.

Detailed look at two common types of solid tumour - melanoma and lung cancer. Includes NHS diagnostic pathway, genetic cause and treatments.

Overview of mitosis and meiosis with diagrams. Overview of mammalian gametogenesis, formation of egg and sperm and overview of fertilization.