Protein Science

For a second year Imperial College student studying Biochemistry Content is detailed & extensive. Content includes: - Mass spectrometry (pros/cons, parts, mass spec data, ionisation sources, mass analysers and their performance characteristics, TOF analysers, hybrid instrument) - Peptide sequencing (ES-MS/MS, etc.) - Interpreting MS Spectra - Proteomics - Post translational modifications (features, effects, types, etc.) - Catalytic antibodies/ Abzymes (including Cocaine case study) -...

Second year student studying for a Biochemistry/Biotechnology degree Content: - Protein dynamics by NMR - Mass Spectrometry in great detail (includes ionisation sources, schematic diagrams, types of Mass spec like Quadrupole mass filters, etc.) - Parts of a mass spectrometer (Mass analyser, etc.) - Performance characteristics of each type of mass spectrometry - Types of ion detectors in its details - How to read Mass spec data (molecular ions/ fragmented ions and y ion/ b ion pathway)...

Second year student, studying for a biochemistry or a biotechnology degree. Content - How we produce antibodies - Immunoglobulin (types, folds, etc.) - Light and heavy chain sequences - Abzymes - Transition happen state approach: treating overdosing of cocaine - Designing catalytic antibodies: 3 steps (with diagrams) - Prodrug activation - Advantages & limitations of catalytic antibodies

Topics covered: o Therapies involving modified antibodies o Catalytic antibodies with example of hapten selection for cocaine degradation o Antibody-drug conjugates to deliver toxic payloads to specific tissues o Virtual drug screening and drug discovery pathways o Drug metabolism  Drug modification  Drug inactivation