Diseases of Ageing (BIOL0027)

Detailed notes on the different model organisms used to study the biology of ageing. A case study is included on Rapamycin found to extend lifespan and how it has been studied in different organisms.

This document provides definitions to the jargon used in Lecture 4 (Cellular senescence as a cause of senescent pathology). It is useful to understand the different diseases mentionned in the lecture.

Detailed lecture notes explaining what is cellular senescence, what triggers senescence, what are the properties of a senescent cell, and whether senescence is causative/driving ageing.

Detailed notes explaining the dominating theories of ageing: evolutionary (mutation accumulation, antagonistic pleiotropy) and mechanistic (damage versus maintenance, hyperfunction).

This document explains the jargon used in Lecture 3 (Model Organisms of Ageing). Very useful to understand the examples of how model organisms have been used to study ageing.

In addition to the notes of lecture 3 (Model Organisms of Ageing), here are four post-it notes summarising how the four key model organisms (mice, drosophila, c. elegans and yeast) are used to study the biology of ageing.

Detailed lecture notes explaining the major theories and aims of studying ageing/senescence as a pathology from a scientific point of view.