Ligand binding Samenvattingen, Aantekeningen en Examens

PHA2022 Pharmacology considers: - Pharmacotherapy: o Drug-response relationship o Selectivity of action o Structure-action relationship Lecture 1 1. Define the terms pharmacodynamics and pharmacokinetics 2. Describe (with examples) the non-specific ways in which drugs can produce therapeutic effects 3. Discuss the four specific molecular targets of drug action 4. Explain the importance of selectivity and how drugs can produce unwanted effects ONE Pharmacodynamics: how the drug acts o...

ligand Correct Answer-a small molecule that binds specifically to a larger one (i.e., protein). For example, a hormone is the ligand for its specific protein receptor [a molecule bound reversibly by a protein. binding site Correct Answer-the location (crevice or pocket) on a receptor protein to which a ligand binds induced fit Correct Answer-The change in shape of the active site of an enzyme so that it binds more snugly to the substrate, induced by entry of the substrate. Renders the subs...

ligand - Is the word for a drug or a bio molecule a molecule that is reversibly bound to a protein, examples oxygen, endogenous neurotransmitters, hormones, drug molecules Binding site - A discrete portion of the protein that is complementary to the ligand in: - Shape and size - Charge distribution - Hydrophobic and hydrophilic regions ***Is involved in specific interaction, certain structural features must be present on the ligand for binding Induced fit - A complementary conformationa...

ABSITE Exam Questions And Answers 100% Correct Latest (Graded A+). The vagus nerve mediates what in the setting of systemic inflammation? Correct Answer: Enhanced gut motility What type of hormones are cytokines? Correct Answer: polypeptide Function of heat shock proteins Correct Answer: Binding of autologous proteins to improve ligand binding Omega-3 fatty acids have what affect on the inflammatory response? Correct Answer: Decrease What is a known affect of TNF? Correct Answer: Expressi...

TEST BANK PATHOPHYSIOLOGY THE BIOLOGICAL BASIS FOR DISEASE IN ADULTS AND CHILDREN BY McCance Chapter 1: Cellular Biology MULTIPLE CHOICE 1. Which statement best describes the cellular function of metabolic absorption? a. Cells can produce proteins. c. Cells can take in and use nutrients. b. Cells can secrete digestive enzymes. d. Cells can synthesize fats. ANS: C In metabolic absorption, all cells take in and use nutrients and other substances from their surroundings. The remaini...

Psychopharm Exam 1 practice 170 Questions with Verified Answers The PMHNP is evaluating a 68-year-old man for symptoms of major depression. While assessing the appearance of the patient, an obvious left-sided ptosis is noted. Which cranial nerve is directly linked to this condition? a. III b. IV c. V d. VI - CORRECT ANSWER A A 55-year-old woman has been referred for a psychiatric evaluation for a change in personality, lack of impulse control, and increasingly reckless decision-making....

a ______ binds at a specific site on the protein called the ___________ correct answers ligand, binding site the binding of a ligand may cause __________ in the protein correct answers a conformational change the amount of oxygen can ________ correct answers limit an organisms size oxygen is poorly soluble in ______ correct answers aqueous solutions myoglobin correct answers monomeric protein hemoglobin correct answers tetrameric protein myoglobin is an example of ______ correc...

What factors affect binding affinity? Correct Answer-Shape, charge, H-bonding, hydrophobics reversible binding Correct Answer-the association of a protein with its ligan is concentration-dependent K_d Correct Answer-the concentration of ligand at which 1/2 of the protein is ligand-bound K_d = k_d / k_a or k_off / k_on also = k_-1 / k_1 Calculate fraction of protein bound to ligand Correct Answer-[L] / ([L] + K_d) affinity and concentration association Correct Answer-if they bind at...

nonpolar endocrines IF covers short distances, endocrines travel in plasma What is the only type of ligand utilizing plasma binding protein? no! brings it TO the cell uber brings you to the store, not into it T or F? does plasma binding protein bring message into cell? nonpolar ligand + intracellular receptor = message transcription which pathway increases or decreases transcription? metabolize receptors (intracellular receptor, cannot be done with membrane bound how could we stop m...

Spectroscopy Methods correct answers- Fluorescence Microscopy - super resolution microscopy - flow cytometry / mass cytometry Ligand binding can be tested by correct answers- equilibrium dialysis - Fluorescence (anisotropy) - FRET - SPR Enzyme kinetics can be tested by correct answers- UV-Vis spectroscopy - Fluorescence - FRET Modes of inhibition correct answers UV-Vis spectroscopy correct answers- light absorption by chromophores - measure the amount of l...