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Oxford IB Biology 2014

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Full IB Oxford Biology Textbook, perfect questions, covers up hl and sl perfectly, most topics are the same with a levels

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OXFORD IB DIplOm a pROgRam m e




2 0 1 4 ED I TI O N




BIOLO GY
C O U R S E C O M PA N I O N




Andrew Allott
David Mindorf

, PHOTO LIBRARY; p101-102: OUP; p110: SPL; p116: Author Image; p122: 

3
Great Clarendon Street, Oxford, OX2 6DP, United Kingdom
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MATTHEW OLDFIELD/SCIENCE PHOTO LIBRARY; p124b: Author Image;
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Oxford University Press is a department of the University of Oxford. It William Allott; p134: OUP; p141: OUP; p143a: Jax.org; p143b: Jax.org; p143c:
furthers the Universitys objective of excellence in research, scholarship, Jax.org; p144: www.ncbi.nlm.nih.gov/pubmed; p146a: Eye of Science/SPL;
and education by publishing worldwide. Oxford is a registered trade mark p146b: Eye of Science/SPL; p148: MAURO FERMARIELLO/SCIENCE PHOTO
of Oxford University Press in the UK and in certain other countries LIBRARY; p150a: M .Wurtz/Biozentrum/University o fBasel/SPL; p150b:
 Oxford University Press 2014 Kwangshin Kim/SPL; p151: www.ncbi.nlm.nih.gov; p152: Dr. Oscar Lee
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First published in 2014 HOSPITAL/SCIENCE PHOTO LIBRARY; p158b: Tomasz Markowski/
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permitted by law, by licence or under terms agreed with the appropriate OUP; p166c: OUP; p169: OUP; p171a: OUP; p171b: OUP; p172: William Allott;
reprographics rights organization. Enquiries concerning reproduction p176: Enrico Coen; p177-184a: OUP; p184b: OUP; p186: RIA NOVOSTI/
outside the scope of the above should be sent to the Rights Department, SCIENCE PHOTO LIBRARY; p188: VOLKER STEGER/SCIENCE PHOTO
Oxford University Press, at the address above. LIBRARY; p189: OUP; p190a: Andrew Allot; p190b: DAVID PARKER/SCIENCE
PHOTO LIBRARY; p190c-196c: OUP; p197: WALLY EBERHART, VISUALS
You must not circulate this work in any other form and you must impose
UNLIMITED /SCIENCE PHOTO LIBRARY; p198a: GERARD PEAUCELLIER, ISM
this same condition on any acquirer
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British Library Cataloguing in Publication Data PHOTO LIBRARY; p198c: Author Image; p199: PHILIPPE PLAILLY/SCIENCE
Data available PHOTO LIBRARY; p201: OUP; p202: Parinya Hirunthitima/Shutterstock;
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Paper used in the production of this book is a natural, recyclable product OUP; p207b: Author Image; p209: Author Image; p210: OUP; p211: OUP;
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conforms to the environmental regulations of the country of origin. Andrew Allott; p215c: Andrew Allott; p215d: Rich Lindie/Shutterstock;
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Giorgiogp2/Wikipedia; p223a: Andrew Allott; p223b: Andrew Allott; p224:
Acknowledgements OUP; p225a: OUP; p225b: Andrew Allott; p225c: Andrew Allott; p228-242b:
The publishers would like to thank the following for permissions to use OUP; p243: Erik Lam/Shutterstock; p244: Sinclair Stammers/SPL; p246a:
their photographs: Wikipedia; p246b: Daiju AZUMA; p246c: Wikipedia; p246d: Shutterstock;
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Institute of Marine Biology, Bermen Germany; p7a: Prof. P.Motta & T. p261: OUP; p262a: OUP; p262b: OUP; p264: Andrew Allot; p265: Kipling
Naguro/ SPL; p7b: Andrew Allot; p7c: Andrew Allot; p7d: MICHAEL ABBEY/ Brock/Shutterstock; p270a: Author Image; p270b: Author Image; p272: OUP;
SCIENCE PHOTO LIBRARY; p8a: Carolina Biological Supply Co/Visuals p276a: OUP; p276b: BOB GIBBONS/SCIENCE PHOTO LIBRARY; p279: BSIP
Unlimited, Inc.; p8b: ASTRID & HANNS-FRIEDER MICHLER/SCIENCE PHOTO VEM/SCIENCE PHOTO LIBRARY; p281: Dennis Kunkel/Photolibrary; p282:
LIBRARY; p9: MICHAEL ABBEY/SCIENCE PHOTO LIBRARY; p10a: DR. PETER Author Image; p283a: Andrew Allot; p283b: OUP; p286: Author Image; p290:
SIVER, VISUALS UNLIMITED /SCIENCE PHOTO LIBRARY; p10b: Sulston & Public Domain/Wikipedia; p292a: OUP; p292b: OUP; p294a: OUP; p294b:
Horvitz; p12: JAMES CAVALLINI/SCIENCE PHOTO LIBRARY; p14a: CHRIS BIOPHOTO ASSOCIATES/SCIENCE PHOTO LIBRARY; p298: Andrew Allot;
BARRY/VISUALS UNLIMITED, INC. /SCIENCE PHOTO LIBRARY; p14b: SIMON p299: OUP; p302: OUP; p303a: OUP; p303b: Andrew Allot; p304a: OUP;
FRASER/DEPARTMENT OF HAEMATOLOGY, RVI, NEWCASTLE/SCIENCE p304b: OUP; p305: JAMES CAVALLINI/SCIENCE PHOTO LIBRARY; p306: ST
PHOTO LIBRARY; p16a: TEK IMAGE/SCIENCE PHOTO LIBRARY; p17: MARYS HOSPITAL MEDICAL SCHOOL/SCIENCE PHOTO LIBRARY; p307:
LAWRENCE BERKELEY NATIONAL LABORATORY/ SCIENCE PHOTO LIBRARY; OUP; p308: Wikipedia; p309: OUP; p315: OUP; p317: DU CANE MEDICAL
p19: A B Dowsett/SPL; p20a: Eye of Science/SPL; p20b: CNRI/SCIENCE PHOTO IMAGING LTD/SCIENCE PHOTO LIBRARY; p318: OUP; p320a: OUP; p320b:
LIBRARY; p21a: BIOPHOTO ASSOCIATES/SCIENCE PHOTO LIBRARY; p21b: THOMAS DEERINCK, NCMIR/SCIENCE PHOTO LIBRARY; p323: OUP; p325:
MICROSCAPE/SCIENCE PHOTO LIBRARY; p22a: BIOPHOTO ASSOCIATES/ BSIP VEM/SCIENCE PHOTO LIBRARY; p327: OUP; p328a: SCIENCE VU,
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MICROSCAPE/SCIENCE PHOTO LIBRARY; p22e: DR KARI LOUNATMAA/ RIDGE NATIONAL LABORATORY/US DEPARTMENT OF ENERGY/SCIENCE
SCIENCE PHOTO LIBRARY; p22f: MICROSCAPE/SCIENCE PHOTO LIBRARY; PHOTO LIBRARY; p333: OUP; p334: POWER AND SYRED/SCIENCE PHOTO
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MURTI/SCIENCE PHOTO LIBRARY; p23c: Andrew Allot; p24a: STEVE Image; p343: SIMON FRASER/SCIENCE PHOTO LIBRARY; p344:  LEE D.
GSCHMEISSNER/SCIENCE PHOTO LIBRARY; p24b: DR.JEREMY BURGESS/ SIMON/SCIENCE PHOTO LIBRARY; p346: SPL; p348: Image of PDB ID 1aoi (K.
SCIENCE PHOTO LIBRARY; p25a: STEVE GSCHMEISSNER/SCIENCE PHOTO Luger, A.W. Mader, R.K. Richmond, D.F. Sargent, T.J. Richmond (1997)
LIBRARY; p25b: DAVID M. PHILLIPS/SCIENCE PHOTO LIBRARY; p25c: STEVE structure of the core particle at 2.8 A resolution Nature 389: 251-260)
GSCHMEISSNER/SCIENCE PHOTO LIBRARY; p27: Author Image; p28: NIBSC/ created with Chimera (UCSF Chimera--a visualization system for exploratory
SCIENCE PHOTO LIBRARY; p29: Author Image; p32: Janaka Dharmasena/ research and analysis. Pettersen EF, Goddard TD, Huang CC, Couch GS,
Shutterstock; p43a: OUP; p43b: Andrew Allot; p44: Herve Conge/SPL; p45: Greenblatt DM, Meng EC, Ferrin TE. J Comput Chem. 2004 Oct;25(13):1605-
David Mayer, Consultant and CSL Liver Surgery, Queen Elizabeth Hospital, 12. ); p349: Public Domain/Wikipedia; p351: SCIENCE PHOTO LIBRARY;
Birmingham; p46a: THOMAS DEERINCK, NCMIR/SCIENCE PHOTO LIBRARY; p352: Andrew Allot; p353: Charvosi/Wikipedia; p357: Axel Bueckert/
p46b: The VRoma Project (www.vroma.org); p48: GEORGETTE DOUWMA/ Shutterstock; p358: PNAS.Org; p359: DR ELENA KISELEVA/SCIENCE PHOTO
SCIENCE PHOTO LIBRARY; p49: DAVID MCCARTHY/SCIENCE PHOTO LIBRARY; p363a: Jmol; p363b: RCSB.org; p367:  1970 American Association
LIBRARY; p51: M.I. Walker/SPL; p53a,b,c,d: STEVE GSCHMEISSNER/SCIENCE for the Advancement of Science. Miller, O. L. et al. Visualization of bacterial
PHOTO LIBRARY; p54a,b: STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY; genes in action. Science 169,392395 (1970). All rights reserved; p368a:
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Kiseleva/SPL; p73b: Dr. Gopal Murti/SPL; p73c: Dr. Elena Kiseleva/SPL; p75a: SPL; p392: Andrew Allot; p398: Andrew Allot; p399: Barrie Juniper; p403:
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LIBRARY; p79: OUP; p80a: Andrew Allot; p80b-81: OUP; p83a: OUP; p83b: LIBRARY; p406a: POWER AND SYRED/SCIENCE PHOTO LIBRARY; p406b: DR
Giles Bell; p90a: OUP; p90b: www.rcsb.org; p91: www.rcsb.org; p92a: KEITH WHEELER/SCIENCE PHOTO LIBRARY; p410: SIDNEY MOULDS/
Yikrazuul/Wikipedia; p92b: OUP; p95: JAMES KING-HOLMES/SCIENCE SCIENCE PHOTO LIBRARY; p411: DR KEITH WHEELER/SCIENCE PHOTO
Continued on back page.

,Contents
1 Cell Biology 7 Nucleic acids (AHL) Environmental protection 5 75
Introduction to cells 1 D NA structure and Medicine 5 82
Ultrastructure o cells 16 replication 3 43 B ioormatics 5 91
Membrane structure 25 Transcription and gene
Membrane transport 33 expression 355 C Ecology and conservation
The origin o cells 45 Translation 3 62 Species and communities 603
C ell division 51 C ommunities and
8 Metabolism, cell ecosystems 61 3
2 Molecular Biology respiration and Impacts o humans on
Molecules to metabolism 61 photosynthesis (AHL) ecosystems 62 5
Water 68 Metabolism 3 73 C onservation o biodiversity 63 5
C arbohydrates and lipids 73 C ell respiration 3 80 Population ecology 642
Proteins 87 Photosynthesis 3 89 The nitrogen and
E nzymes 96 phosphorous cycles 649
S tructure o D NA and RNA 1 05 9 Plant biology (AHL)
D NA replication, transcription Transport in the xylem D Human physiology
and translation 111 o plants 403 Human nutrition 65 9
C ell respiration 1 22 Transport in the phloem o D igestion 671
Photosynthesis 1 29 plants 41 2 Functions o the liver 678
Growth in plants 42 2 The heart 684
3 Genetics Reproduction in plants 42 9 Hormones and metabolism 694
Genes 1 41 Transport o respiratory
C hromosomes 1 49 10 Genetics and evolution gases 699
Meiosis 1 59 (AHL) Internal Assessment
Inheritance 1 68 Meiosis 43 9 (with thanks to Mark Headlee for
Genetic modication and Inheritance 445 his assistance with this chapter) 708
biotechnology 1 87 Gene pool and speciation 45 5
Index 71 3
4 Ecology 11 Animal physiology (AHL)
S pecies, communities and Antibody production and
ecosystems 2 01 vaccination 465
E nergy fow 21 3 Movement 476
C arbon cycling 220 The kidney and
C limate change 229 osmoregulation 485
S exual reproduction 499
5 Evolution and biodiversity
E vidence or evolution 2 41 A Neurobiology and
Natural selection 2 49 behaviour
C lassication and Neural development 513
biodiversity 258 The human brain 518
C ladistics 2 63 Perception o stimuli 526
Innate and learned
6 Human physiology behaviour 533
D igestion and absorption 2 79 Neuropharmacology 5 41
The blood system 2 89 Ethology 5 48
D eence against inectious
diseases 3 02 B Biotechnology and
Gas exchange 31 0 bioinformatics
Neurones and synapses 31 9 Microbiology: organisms in
Hormones, homeostasis and industry 557
reproduction 329 B iotechnology in agriculture 5 65

iii

, Course book defnition The IB Learner Profle
The IB D iploma Programme course books are The aim o all IB programmes to develop
resource materials designed to support students internationally minded people who work to create
throughout their two- year D iploma Programme a better and more peaceul world. The aim o the
course o study in a particular subj ect. They will programme is to develop this person through ten
help students gain an understanding o what learner attributes, as described below.
is expected rom the study o an IB D iploma
Inquirers: They develop their natural curiosity.
Programme subj ect while presenting content in a
They acquire the skills necessary to conduct
way that illustrates the purpose and aims o the IB .
inquiry and research and snow independence in
They refect the philosophy and approach o the
learning. They actively enj oy learning and this love
IB and encourage a deep understanding o each
o learning will be sustained throughout their lives.
subj ect by making connections to wider issues and
providing opportunities or critical thinking. Knowledgeable: They explore concepts, ideas,
and issues that have local and global signicance.
The books mirror the IB philosophy o viewing the
In so doing, they acquire in-depth knowledge and
curriculum in terms o a whole- course approach;
develop understanding across a broad and balanced
the use o a wide range o resources, international
range o disciplines.
mindedness, the IB learner prole and the IB
D iploma Programme core requirements, theory Thinkers: They exercise initiative in applying
o knowledge, the extended essay, and creativity, thinking skills critically and creatively to recognize
action, service ( C AS ) . and approach complex problems, and make
reasoned, ethical decisions.
E ach book can be used in conj unction with other
materials and indeed, students o the IB are C ommunicators: They understand and express
required and encouraged to draw conclusions rom ideas and inormation condently and creatively in
a variety o resources. Suggestions or additional more than one language and in a variety o modes
and urther reading are given in each book o communication. They work eectively and
and suggestions or how to extend research are willingly in collaboration with others.
provided. Princip led: They act with integrity and honesty,
In addition, the course companions provide advice with a strong sense o airness, j ustice and respect
and guidance on the specic course assessment or the dignity o the individual, groups and
requirements and on academic honesty protocol. communities. They take responsibility or their
They are distinctive and authoritative without own action and the consequences that accompany
being prescriptive. them.
O p en-minded: They understand and appreciate
IB mission statement their own cultures and personal histories, and are
The International B accalaureate aims to develop open to the perspectives, values and traditions
inquiring, knowledgeable and caring young people o other individuals and communities. They are
who help to create a better and more peaceul accustomed to seeking and evaluating a range o
world through intercultural understanding and points o view, and are willing to grow rom the
respect. experience.
To this end the organization works with schools, C aring: They show empathy, compassion and
governments and international organizations to respect towards the needs and eelings o others.
develop challenging programmes o international They have a personal commitment to service, and
education and rigorous assessment. to act to make a positive dierence to the lives o
These programmes encourage students across the others and to the environment.
world to become active, compassionate and lielong Risk-takers: They approach unamiliar situations
learners who understand that other people, with and uncertainty with courage and orethought,
their dierences, can also be right. and have the independence o spirit to explore
new roles, ideas, and strategies. They are brave and
articulate in deending their belies.


iv

,B alanced: They understand the importance o What constitutes malpractice?
intellectual, physical and emotional ballance to Malpractice is behaviour that results in, or may
achieve personal well- being or themselves and result in, you or any student gaining an unair
others. advantage in one or more assessment component.
Refective: They give thoughtul consideration Malpractice includes plagiarism and collusion.
to their own learning and experience. They are Plagiarism is defned as the representation o the
able to assess and understand their strengths and ideas or work o another person as your own. The
limitations in order to support their learning and ollowing are some o the ways to avoid plagiarism:
personal development.
 words and ideas o another person to support
ones arguments must be acknowledged
A note on academic honesty
It is o vital importance to acknowledge and  passages that are quoted verbatim must
appropriately credit the owners o inormation be enclosed within quotation marks and
when that inormation is used in your work. acknowledged
Ater all, owners o ideas ( intellectual property)  C D -Roms, email messages, web sites on the
have property rights. To have an authentic piece Internet and any other electronic media must
o work, it must be based on your individual be treated in the same way as books and
and original ideas with the work o others ully j ournals
acknowledged. Thereore, all assignments, written
or oral, completed or assessment must use your
 the sources o all photographs, maps,
own language and expression. Where sources are illustrations, computer programs, data, graphs,
used or reerred to, whether in the orm o direct audio- visual and similar material must be
quotation or paraphrase, such sources must be acknowledged i they are not your own work
appropriately acknowledged.  works o art, whether music, flm dance,
How do I acknowledge the work of others? theatre arts or visual arts and where the
The way that you acknowledge that you have used creative use o a part o a work takes place, the
the ideas o other people is through the use o original artist must be acknowledged.
ootnotes and bibliographies. C ollusion is defned as supporting malpractice by
Footnotes ( placed at the bottom o a page) or another student. This includes:
endnotes ( placed at the end o a document) are  allowing your work to be copied or submitted
to be provided when you quote or paraphrase or assessment by another student
rom another document, or closely summarize the
 duplicating work or dierent assessment
inormation provided in another document. You
components and/or diploma requirements.
do not need to provide a ootnote or inormation
that is part o a body o knowledge. That is, O ther orms o malp ractice include any action
defnitions do not need to be ootnoted as they are that gives you an unair advantage or aects the
part o the assumed knowledge. results o another student. Examples include,
taking unauthorized material into an examination
B ibliograp hies should include a ormal list o the
room, misconduct during an examination and
resources that you used in your work. Formal
alsiying a C AS record.
means that you should use one o the several
accepted orms o presentation. This usually
involves separating the resources that you use
into dierent categories ( e.g. books, magazines,
newspaper articles, internet-based resources, C ds
and works o art) and providing ull inormation
as to how a reader or viewer o your work can
fnd the same inormation. A bibliography is
compulsory in the E xtended Essay.




v

, Using your IB Biology
Online Resources
What is Kerboodle?
Kerboodle is an online learning platorm. I your school has a
subscription to IB B iology Kerboodle O nline Resources you will be able
to access a huge bank o resources, assessments, and presentations to
guide you through this course.

What is in your Kerboodle Online Resources?
There are three main areas or students on the IB B iology Kerboodle:
planning, resources, and assessment.

Resources
There a hundreds o extra resources available on the IB B iology
Kerboodle O nline. You can use these at home or in the classroom to
develop your skills and knowledge as you progress through the course.
Watch videos and animations o experiments, difcult concepts, and
science in action.
Hundreds o worksheets  read articles, perorm experiments and
simulations, practice your skills, or use your knowledge to answer
questions.
Look at galleries o images rom the book and see their details close up.
Find out more by looking at recommended sites on the Internet,
answer questions, or do more research.

Planning
B e prepared or the practical work and your internal assessment with
extra resources on the IB B iology Kerboodle online.
Learn about the dierent skills that you need to perorm an investigation.
Plan and prepare experiments o your own.
Learn how to analyse data and draw conclusions successully
and accurately.




One of hundreds of worksheets. Practical skills presentation.
vi

,Assessment
C lick on the assessment tab to check your knowledge or revise or your
examinations. Here you will fnd lots o interactive quizzes and exam-
style practice questions.
Formative tests: use these to check your comprehension, theres one
auto-marked quiz or every sub-topic. E valuate how confdent you
eel about a sub-topic, then complete the test. You will have two
attempts at each question and get eedback ater every question. The
marks are automatically reported in the markbook, so you can see
how you progress throughout the year.
Summative tests: use these to practice or your exams or as revision,
theres one auto- marked quiz or every topic. Work through the test
as i it were an examination  go back and change any questions you
arent sure about until you are happy, then submit the test or a fnal
mark. The marks are automatically reported in the markbook, so you
can see where you may need more practice.
Assessment practice: use these to practice answering the longer
written questions you will come across when you are examined.
These worksheets can be printed out and perormed as a timed test.




Don't forget!
You can also fnd extra resources on our ree website
www.oxfordsecondary.co.uk/ib-biology
Here you can fnd all o the answers
and even more practice questions.

vii

, Introduction Nature of science
This book is a companion or students o B iology
Here you can explore the methods o science and
in the International B accalaureate D iploma
some o the knowledge issues that are associated
Programme.
with scientifc endeavour. This is done using
B iology is the most popular choice o science careully selected examples, including biological
subj ect as part o the IB diploma. The study o research that led to paradigm shits in our
biology should lead students to appreciate the understanding o the natural world.
interconnectedness o lie within the biosphere.
With a ocus on understanding the nature o
science, IB B iology will allow you to develop a
Theory of Knowledge
level o scientifc literacy that will better prepare These short sections have headings that are equivocal
you to act on issues o local and global concern, ` knowledge questions. The text that follows often
with a ull understanding o the scientifc point details one possible answer to the knowledge question.
o view. We encourage you draw on these examples of
The structure o this book is closely based on the knowledge issues in your TOK essays. Of course, much
biology programme in the S ubj ect Guide. S ub- of the material elsewhere in the book, particularly in the
headings restate the specifc assessment statements. nature of science sections, can be used to prompt TOK
Topics 1  6 explain in detail the C ore material
discussions.
that is common to both S L and HL courses. Topics
7  1 1 explain the AHL ( additional higher level
material) . Topics A, B , C and D cover the content
activity
o the options. All topics include the ollowing
A variety of short topics are included under this heading
elements:
with the focus in all cases on active learning. We
encourage you research these topics yourself, using
Understanding information available in textbooks or on the Internet. The
The specifcs o the content requirements or aim is to promote an independent approach to learning.
each sub- topic are covered in detail. C oncepts are We believe that the optimal approach to learning is to
presented in ways that will promote enduring be active  the more that you do for yourself, guided by
understanding. your teacher, the better you will learn.

Applications Data-based questions
These sections help you to develop your
These questions involve studying and analysing data
understanding by studying a specifc illustrative
from biological research  this type of question appears
example or learning about a signifcant experiment
in both Paper 2 and Paper 3 for SL and HL IB Biology.
in the history o biology.
Answers to these questions can be found at
www.oxfordsecondary.co.uk/ib-biology
Skills topics
These sections encourage you to apply your
understanding through practical activities End -of-Topic Questions
and analysis o results rom classic biological At the end o each topic you will fnd a range o
research. In some cases this involves instructions questions, including both past IB B iology exam
or handling data rom experiments and also questions and new questions. Answers can be
use o IC T. Some o the skills sections involve ound at www.oxordsecondary. co.uk/ib- biology
experiments with known outcomes, aimed at
promoting understanding through doing and
seeing. O thers involve ideas or experimental
work with unknown outcomes, where you can
defne the problem and the methods. These are a
valuable opportunities to build the skills that are
assessed in IA ( see page 708) .


viii

,1 CE LL B I O LO GY
Introduction
There is an unbroken chain o lie rom the rst in prokaryotes and eukaryotes. While evolution
cells on Earth to all cells ound in organisms has resulted in a biological world o enormous
alive today. Eukaryotes have a much more diversity, the study o cells shows us that
complex cell structure than prokaryotes. The there are also universal eatures. For example,
evolution o multicellular organisms allowed the fuid and dynamic structure o biological
cell specialization and cell replacement. C ell membranes allows them to control the
division is essential but is carried out dierently composition o cells.




1.1 Introduction to cells
Understanding Applications
 According to the cell theory, living organisms
 Questioning the cell theory using atypical
are composed o cells. examples, including striated muscle, giant
 Organisms consisting o only one cell carry out algae and aseptate ungal hyphae.
all unctions o lie in that cell.  Investigation o unctions o lie in
 Surace area to volume ratio is important in the Paramecium and one named photosynthetic
limitation o cell size. unicellular organism.
 Multicellular organisms have properties  Use o stem cells to treat Stargardts disease
that emerge rom the interaction o their and one other named condition.
cellular components.  Ethics o the therapeutic use o stem cells rom
 Specialized tissues can develop by cell specially created embryos, rom the umbilical
dierentiation in multicellular organisms. cord blood o a new-born baby and rom an
 Dierentiation involves the expression o some adults own tissues.
genes and not others in a cells genome.
 The capacity o stem cells to divide and
dierentiate along dierent pathways is
necessary in embryonic development. It also
makes stem cells suitable or therapeutic uses.


Nature of science Skills
 Looking or trends and discrepancies: although  Use o a light microscope to investigate the
most organisms conorm to cell theory, there structure o cells and tissues.
are exceptions.  Drawing cell structures as seen with the
 Ethical implications o research: research light microscope.
involving stem cells is growing in importance  Calculation o the magnifcation o drawings
and raises ethical issues. and the actual size o structures shown in
drawings or micrographs.


1

, 1 C E LL B I O LO G Y

The cell theory
Living organisms are composed of cells.
The internal structure of living organisms is very intricate and is built
up from very small individual parts. O rgans such as the kidney and
the eye are easily visible. If they are dissected we can see that large
organs are made of a number of different tissues, but until microscopes
were invented little or nothing was discovered about the structure of
tissues. From the 1 7th century onwards biologists examined tissues
from both plants and animals using microscopes. Although there was
much variation, certain features were seen again and again. A theory
was developed to explain the basic features of structure  the cell theory.
This states that cells are the fundamental building blocks of all living
organisms. The smallest organisms are unicellular  they consist of j ust
one cell. Larger organisms are multicellular  they are composed of
many cells.
C ells vary considerably in size and shape but they share certain common
features:
 Every living cell is surrounded by a membrane, which separates the
cell contents from everything else outside.
 C ells contain genetic material which stores all of the instructions
needed for the cells activities.
 Many of these activities are chemical reactions, catalysed by enzymes
produced inside the cell.
 C ells have their own energy release system that powers all of the
cells activities.
S o, cells can be thought of as the smallest living structures  nothing
smaller can survive.




 Figure 1 Coloured scanning electron micrograph (SEM) of a human embryo on the tip of a pin
2

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