Doac Study guides, Class notes & Summaries

Dabigatran (Pradaxa) Dosing - Answer *Treatment of DVT/PE:* 150 mg BID after 5-10 days of parenteral therapy *VTE Prophylaxis:* Total hip - 110 mg once 1-4 hours after surgery and hemostasis then 220 mg once daily for 10-35 days *Nonvalvular A fib:* 150 mg BID Dabigatran (Pradaxa) DDI - Answer *P-glycoprotein inhibitors* (dronedarone, ketoconazole, verapamil, clarithromycin, quinidine) *P-glycoprotein inducers* (Rifampin, carbamazepine) --- at risk for stroke, VTE, etc if u...

T/F Anticoagulants dissolve/breakdown clots - Answer false! only prevent clots from forming and keep existing clots from getting larger Anticoagulant uses - Answer ACS prevention of cardioembolic stroke prevention/treatment of VTE (DVT and/or PE) Warfarin inhibits which factors? - Answer II VII IX X (2, 7, 9, 10) Factor Xa inhibitors (direct) - Answer rivaroxaban apixaban edoxaban betrixaban indirect factor Xa inhibitor - Answer fondaparinux via antithrombin ...

What are DOACs used for? - Answer - VTE treatment and prophylaxis - stroke prevention (non-valvular a fib) - CAD and PAD What advantages does DOACs have over warfarin? - Answer - fixed dosing - predictable - quick onset - minimal drug-food/drug interactions - less monitoring -wide TR Does DOACs or warfarin have to deal with genetic polymorphisms? - Answer warfarin What DOACs are prodrugs? - Answer dabigatran What substrate is dabigatran? - Answer p-gp How is dabi...

Following Up on DOACs: Checklist - Answer - Compliance: check adherence and educate on importance - Thromboembolism: check for recurrence of clotting - Bleeding: educate on bleed prevention and management - Other ADRs: no many - Co-Medications: check for DDIs Blood Sampling: renal & hepatic Functions Drug Interactions Considerations: Warfarin - Answer - Interacting drugs are NOT contraindicated - Can be managed through increased INR monitoring and dose adjustments Drug Interactio...

Which important factors should be considered prior to initiating ferrous sulfate therapy? - The use of antacids; the absorption of oral iron formulations is decreased by medications that increase the pH of the stomach. With Todd's history of GERD, it would be important to find out if he is currently on medications to relieve his symptoms, as proton-pump inhibitors, histamine-2 receptor antagonists, and antacids may reduce the absorption of oral iron products. After two weeks of taking ferrous ...

151 - 200 Drug Cards 50 Questions with Answers GENERIC NAME: Codeine Phosphate with Guaifenesin - CORRECT ANSWER Brand: (Mytussin AC, Robitussin AC), Cheratussin AC; Coditussin AC; Dex-Tuss; G Tussin AC; Guatussin AC; Guaifenesin AC Liquid; M-Clear WC; Mar-Cof CG; Ninjacof-XG; Robafen AC; Virtussin A/C, Tussi-Organidin NR, Guiatuss AC, Iophen C-NR Class: Opioid Antitussive; Expectorant, Schedule V. Indication: Cough Dosage Form: Oral syrup, Solution, liquid. Ethinyl Estradio...

Recommendations regarding anticoagulation of patients with valve replacements