Exam (elaborations)
PK DOACS questions with correct answers
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What are DOACs used for? - Answer - VTE treatment and prophylaxis - stroke prevention (non-valvular a fib) - CAD and PAD What advantages does DOACs have over warfarin? - Answer - fixed dosing - predictable - quick onset - minimal drug-food/drug interactions - less monitoring -wide TR Does DOACs or warfarin have to deal with genetic polymorphisms? - Answer warfarin What DOACs are prodrugs? - Answer dabigatran What substrate is dabigatran? - Answer p-gp How is dabigatran activated? - Answer dabigatran etexilate is hydrolyzed by carboxyl esterase Why shouldn't you crush dabigatran? - Answer
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pk doacs questions with correct answers
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