via
tu
ss
lu
Ap
@
,Abrams' Clinical Drug Therapy: Rationales for Nursing Practice 12th Edition
Frandsen Test Bank
Chapter 1 The Foundation of Pharmacology: Quality and Safety
A woman has been prescribed paroxetine
hydrochloride, which is an antidepressant
agent administered in pill form. The
1.
medication is administered for her obsessive-
compulsive disorder. This medication will
produce which of the following effects?
A) Curative
B) Systemic
C) Local
D) Parenteral
Ans: B
Feedback:
Drugs that produce systemic effects are taken
into the body, circulated through the
bloodstream to their sites of action in various
body tissues, and eventually eliminated from
the body. Curative agents are given to cure a
disease process. In this case, paroxetine
hydrochloride will control the symptoms but
not cure the disorder. Drugs with local effects,
such as sunscreen and local anesthetics, act
@
mainly at the site of application. Paroxetine
hydrochloride is not administered
parenterally. Parenteral agents are
administered subcutaneously, intramuscularly,
Ap
or intravenously.
A patient has been prescribed an antibiotic.
This medication is a naturally occurring
lu
2. substance that has been chemically modified.
What is another name for this type of
medication?
ss
A) Synthetic drug
B) Semisynthetic drug
C) Biotechnology drug
D) Prototype drug
tu
Ans: B
Feedback:
v ia
, Semisynthetic drugs (e.g., many antibiotics)
are naturally occurring substances that have
been chemically modified. Synthetic drugs are
more standardized in their chemical
characteristics, more consistent in their
effects, and less likely to produce allergic
reactions. Biotechnology drugs involve
manipulating DNA and RNA and
recombining genes into hybrid molecules that
can be inserted into living organisms.
Prototype drugs are the first drug of a
particular group to be developed.
A patient is administered morphine. Morphine
is a prototypical drug that can be classified in
3.
different ways. Which of the following
classifications applies to morphine?
A) Central nervous system depressant
B) Central nervous system stimulant
C) Anti-inflammatory
D) Antihypertensive
Ans: A
Feedback:
Drugs are classified according to their effects
on particular body systems, their therapeutic
@
uses, and their chemical characteristics. For
example, morphine can be classified as a
central nervous system depressant and a
narcotic or opioid analgesic. A central nervous
Ap
system stimulant increases attention and
raises mood. An anti-inflammatory agent
decreases inflammation at the site of tissue or
joint inflammation. An antihypertensive agent
reduces blood pressure.
lu
A patient is administered amoxicillin
ss
(Amoxil). The generic name of this
4.
medication indicates that it belongs to which
drug group?
A) Selective serotonin reuptake inhibitors
tu
B) Diuretics
C) Penicillins
D) ACE inhibitors
v
Ans: C
ia
, Feedback:
The generic name often indicates the drug
group (e.g., drugs with generic names ending
in ―cillin‖ are penicillins). Selective serotonin
reuptake inhibitors are medications that have
antidepressant effects; SSRI is a broad
classification, not a generic name. Diuretics
are medications that increase urine output;
diuretic is a broad classification, not a generic
name. ACE inhibitor is the broad
classification for the angiotensin-converting
enzyme inhibitors, not the generic name.
The administration of diphenhydramine
(Benadryl), which is an over-the-counter
5.
medication, is regulated by which government
agency?
A) Public Health Service
B) Federal Trade Commission
Occupational Safety and Health
C)
Administration
D) Food and Drug Administration
Ans: D
Feedback:
The Food and Drug Administration approves
@
drugs for over-the-counter availability,
including the transfer of drugs from
prescription to OTC status, and may require
clinical trials to determine the safety and
Ap
effectiveness of OTC use. The Public Health
Service is regulated by the state to maintain
the health of individual citizens of the state.
The Federal Trade Commission regulates
imports and exports throughout the nation.
lu
The Occupational Safety and Health
Administration regulates safety within the
workplace.
ss
The administration of anabolic steroids is
6.
regulated by which of the following laws?
tu
A) The Food, Drug, and Cosmetic Act of 1938
The Comprehensive Drug Abuse Prevention
B)
and Control Act
C) The Harrison Narcotic Act
v ia
,D) The Shirley Amendment
Ans: B
Feedback:
The Comprehensive Drug Abuse Prevention
and Control Act regulates the manufacture
and distribution of narcotics, stimulants,
depressants, hallucinogens, and anabolic
steroids. The Food, Drug, and Cosmetic Act
of 1938 revised and broadened FDA powers
and responsibilities, giving the FDA control
over drug safety. The Harrison Narcotic Act
restricted the importation, manufacture, sale,
and use of opium, cocaine, marijuana, and
other drugs that the act defined as narcotics.
The Shirley Amendment of 1912 prohibited
fraudulent claims of drug effectiveness.
A nurse is responsible for maintaining an
accurate count and record of the controlled
7. substances on the nursing unit. This nursing
action is regulated by which of the following
laws or agencies?
A) Food, Drug, and Cosmetic Act of 1938
B) Public Health Service
C) Drug Enforcement Administration
@
D) Shirley Amendment
Ans: C
Feedback:
The Drug Enforcement Administration
Ap
enforces the Controlled Substances Act.
Under this enforcement, nurses are
responsible for storing controlled substances
in locked containers, administering them only
to the people for whom they are prescribed,
lu
recording each dose given, and maintaining
an accurate inventory. The Food, Drug, and
Cosmetic Act of 1938 revised and broadened
ss
FDA powers and responsibilities, giving the
FDA control over drug safety. The Public
Health Service is regulated by the state to
maintain the health of individual citizens of
tu
the state. The Shirley Amendment of 1912
prohibited fraudulent claims of drug
effectiveness.
v ia
, In Phase I clinical trials, the potential uses and
8. effects of a new drug are determined by
which of the following methods?
A) Administering doses to healthy volunteers
Administering doses to people with the
B)
disease
C) Administering in placebo-controlled design
D) Calculating the risk-to-benefit ratio
Ans: A
Feedback:
Phase I studies allow for the administration of
the medication to healthy volunteers to
determine safe dosages, routes of
administration, absorption, metabolism,
excretion, and toxicity. In Phase II studies, a
few doses are given to a certain number of
subjects with the disease or symptom for
which the drug is being studied and responses
are compared with those of healthy subjects.
Placebo-controlled designs are used in the
Phase III studies, in which half of the subjects
receive the new drug and half receive the
placebo. Calculating the risk-to-benefit ratio
is used in Phase II studies to determine
whether the potential benefits of the drug
@
outweigh the risks.
A new medication for the treatment of
Ap
Alzheimer's disease is being administered to a
group of subjects with the disease. The
subjects receiving this medication are
9.
unaware of whether they are being
administered the medication or whether they
lu
are receiving a placebo. This testing occurs in
which phase of the drug approval process?
A) Phase I
ss
B) Phase II
C) Phase III
D) Phase IV
Ans: C
tu
Feedback:
v ia
tu
ss
lu
Ap
@
,Abrams' Clinical Drug Therapy: Rationales for Nursing Practice 12th Edition
Frandsen Test Bank
Chapter 1 The Foundation of Pharmacology: Quality and Safety
A woman has been prescribed paroxetine
hydrochloride, which is an antidepressant
agent administered in pill form. The
1.
medication is administered for her obsessive-
compulsive disorder. This medication will
produce which of the following effects?
A) Curative
B) Systemic
C) Local
D) Parenteral
Ans: B
Feedback:
Drugs that produce systemic effects are taken
into the body, circulated through the
bloodstream to their sites of action in various
body tissues, and eventually eliminated from
the body. Curative agents are given to cure a
disease process. In this case, paroxetine
hydrochloride will control the symptoms but
not cure the disorder. Drugs with local effects,
such as sunscreen and local anesthetics, act
@
mainly at the site of application. Paroxetine
hydrochloride is not administered
parenterally. Parenteral agents are
administered subcutaneously, intramuscularly,
Ap
or intravenously.
A patient has been prescribed an antibiotic.
This medication is a naturally occurring
lu
2. substance that has been chemically modified.
What is another name for this type of
medication?
ss
A) Synthetic drug
B) Semisynthetic drug
C) Biotechnology drug
D) Prototype drug
tu
Ans: B
Feedback:
v ia
, Semisynthetic drugs (e.g., many antibiotics)
are naturally occurring substances that have
been chemically modified. Synthetic drugs are
more standardized in their chemical
characteristics, more consistent in their
effects, and less likely to produce allergic
reactions. Biotechnology drugs involve
manipulating DNA and RNA and
recombining genes into hybrid molecules that
can be inserted into living organisms.
Prototype drugs are the first drug of a
particular group to be developed.
A patient is administered morphine. Morphine
is a prototypical drug that can be classified in
3.
different ways. Which of the following
classifications applies to morphine?
A) Central nervous system depressant
B) Central nervous system stimulant
C) Anti-inflammatory
D) Antihypertensive
Ans: A
Feedback:
Drugs are classified according to their effects
on particular body systems, their therapeutic
@
uses, and their chemical characteristics. For
example, morphine can be classified as a
central nervous system depressant and a
narcotic or opioid analgesic. A central nervous
Ap
system stimulant increases attention and
raises mood. An anti-inflammatory agent
decreases inflammation at the site of tissue or
joint inflammation. An antihypertensive agent
reduces blood pressure.
lu
A patient is administered amoxicillin
ss
(Amoxil). The generic name of this
4.
medication indicates that it belongs to which
drug group?
A) Selective serotonin reuptake inhibitors
tu
B) Diuretics
C) Penicillins
D) ACE inhibitors
v
Ans: C
ia
, Feedback:
The generic name often indicates the drug
group (e.g., drugs with generic names ending
in ―cillin‖ are penicillins). Selective serotonin
reuptake inhibitors are medications that have
antidepressant effects; SSRI is a broad
classification, not a generic name. Diuretics
are medications that increase urine output;
diuretic is a broad classification, not a generic
name. ACE inhibitor is the broad
classification for the angiotensin-converting
enzyme inhibitors, not the generic name.
The administration of diphenhydramine
(Benadryl), which is an over-the-counter
5.
medication, is regulated by which government
agency?
A) Public Health Service
B) Federal Trade Commission
Occupational Safety and Health
C)
Administration
D) Food and Drug Administration
Ans: D
Feedback:
The Food and Drug Administration approves
@
drugs for over-the-counter availability,
including the transfer of drugs from
prescription to OTC status, and may require
clinical trials to determine the safety and
Ap
effectiveness of OTC use. The Public Health
Service is regulated by the state to maintain
the health of individual citizens of the state.
The Federal Trade Commission regulates
imports and exports throughout the nation.
lu
The Occupational Safety and Health
Administration regulates safety within the
workplace.
ss
The administration of anabolic steroids is
6.
regulated by which of the following laws?
tu
A) The Food, Drug, and Cosmetic Act of 1938
The Comprehensive Drug Abuse Prevention
B)
and Control Act
C) The Harrison Narcotic Act
v ia
,D) The Shirley Amendment
Ans: B
Feedback:
The Comprehensive Drug Abuse Prevention
and Control Act regulates the manufacture
and distribution of narcotics, stimulants,
depressants, hallucinogens, and anabolic
steroids. The Food, Drug, and Cosmetic Act
of 1938 revised and broadened FDA powers
and responsibilities, giving the FDA control
over drug safety. The Harrison Narcotic Act
restricted the importation, manufacture, sale,
and use of opium, cocaine, marijuana, and
other drugs that the act defined as narcotics.
The Shirley Amendment of 1912 prohibited
fraudulent claims of drug effectiveness.
A nurse is responsible for maintaining an
accurate count and record of the controlled
7. substances on the nursing unit. This nursing
action is regulated by which of the following
laws or agencies?
A) Food, Drug, and Cosmetic Act of 1938
B) Public Health Service
C) Drug Enforcement Administration
@
D) Shirley Amendment
Ans: C
Feedback:
The Drug Enforcement Administration
Ap
enforces the Controlled Substances Act.
Under this enforcement, nurses are
responsible for storing controlled substances
in locked containers, administering them only
to the people for whom they are prescribed,
lu
recording each dose given, and maintaining
an accurate inventory. The Food, Drug, and
Cosmetic Act of 1938 revised and broadened
ss
FDA powers and responsibilities, giving the
FDA control over drug safety. The Public
Health Service is regulated by the state to
maintain the health of individual citizens of
tu
the state. The Shirley Amendment of 1912
prohibited fraudulent claims of drug
effectiveness.
v ia
, In Phase I clinical trials, the potential uses and
8. effects of a new drug are determined by
which of the following methods?
A) Administering doses to healthy volunteers
Administering doses to people with the
B)
disease
C) Administering in placebo-controlled design
D) Calculating the risk-to-benefit ratio
Ans: A
Feedback:
Phase I studies allow for the administration of
the medication to healthy volunteers to
determine safe dosages, routes of
administration, absorption, metabolism,
excretion, and toxicity. In Phase II studies, a
few doses are given to a certain number of
subjects with the disease or symptom for
which the drug is being studied and responses
are compared with those of healthy subjects.
Placebo-controlled designs are used in the
Phase III studies, in which half of the subjects
receive the new drug and half receive the
placebo. Calculating the risk-to-benefit ratio
is used in Phase II studies to determine
whether the potential benefits of the drug
@
outweigh the risks.
A new medication for the treatment of
Ap
Alzheimer's disease is being administered to a
group of subjects with the disease. The
subjects receiving this medication are
9.
unaware of whether they are being
administered the medication or whether they
lu
are receiving a placebo. This testing occurs in
which phase of the drug approval process?
A) Phase I
ss
B) Phase II
C) Phase III
D) Phase IV
Ans: C
tu
Feedback:
v ia
