Enzyme kinetics Study guides, Revision notes & Summaries

If the pka of a weak acid is 2.5, at which pH will this drug become more ionized? A. pH 5 B. pH 2.5 C. pH 1.5 D. pH 1 - Answer - A. For a weak acid, a higher pH increases ionization Which equation describes the rate of drug dissolution from a tablet? A. Fick's Law B. Henderson-Hasselbalch equation C. Michaelis-Menten equation D. Noyes-Whitney equation - Answer - D. The Noyes-Whitney equation describes the rate of drug dissolution from a tablet. Fick's first law of diffusion is s...

An α-helical arrangement of amino acids is considered to be what level of protein structure? correct answer: Secondary structure of the protein β- sheets and α-helices are examples of secondary structures. How these structures interact would be an example of tertiary structure. If a mutation is made within the active site of an enzyme resulting in a decrease in Km, which of the following will be true with respect to the enzyme kinetics? correct answer: The enzyme will require a lower ...

TEST BANK for Biochemistry 10th Edition by Jeremy Berg; Gregory Gatto Jr.; Justin Hines; John L. Tymoczko; Lubert Stryer  _TABLE OF CONTENTS_ 1 Biochemistry in Space and Time   2 Protein Comp osition and Structure   3 Binding and Molecular Recognition   4 Protein Methods  5 Enzymes: Core Concepts and Kinetics   6 Enzyme Catalytic Strategies   7 Enzyme Regulatory Strategies   8 DNA, RNA, and the Flow of Genetic Information    9 Nucleic Acid Methods  10 Exploring ...

Absolute binding - correct answer Enzymes that can bind only one substrate and catalyze one reaction exhibit which type of binding specificity? Double - correct answer The rate of an enzymatic reaction will ___________________ for every 10 degrees C temperature increase until the enzyme denatures. c. Myocardial infarction - correct answer All of the following conditions may result in a rise in CKBB levels except. a. Child birth b Spinal chord injury c. Myocardial infarction d. Br...

Pre-PCOA Exam Latest Update (2022/2023) Already Passed Methods to enhance a drug's solubility in a solvent 1. Heat 2. Co-solvents increase the solubility of hydrophobic molecules by reducing the dielectric constant of the solvent 3. pH-Assisted solubility processes of drug elimination from the body liver, kidney and bile primary, secondary, tertiary and quaternary structures of proteins a. 1° primary - amino acid sequence of the polypeptide (Controls levels 2, 3, and 4) b. 2° secondary - l...

LECTURE 7 PSCI EXAM REVIEW QUESTIONS AND ANSWERS, RATED A+ Drug transporters follow what kinetics Michaelis-Menten Enzyme Kinetics Vmax maximum velocity Km Substrate concentration at 1/2 Vmax Types of inhibitors competitive and non-competitiv

Enzymes that can bind only one substrate and catalyze one reaction exhibit which type of binding specificity? correct answer: Absolute binding The rate of an enzymatic reaction will ___________________ for every 10 degrees C temperature increase until the enzyme denatures. correct answer: Double All of the following conditions may result in a rise in CKBB levels except. a. Child birth b Spinal chord injury c. Myocardial infarction d. Brain tumor correct answer: c. Myocardial infarct...

Spectroscopy Methods correct answers- Fluorescence Microscopy - super resolution microscopy - flow cytometry / mass cytometry Ligand binding can be tested by correct answers- equilibrium dialysis - Fluorescence (anisotropy) - FRET - SPR Enzyme kinetics can be tested by correct answers- UV-Vis spectroscopy - Fluorescence - FRET Modes of inhibition correct answers UV-Vis spectroscopy correct answers- light absorption by chromophores - measure the amount of l...

How do most enzymes reduce the activation energy needed to move a reaction forward? correct answer: Providing an active site most complementary the transition state An enzyme has a mutation within the substrate binding of the coenzyme needed for covalent catalysis. Which of the following is likely to result as a consequence of this mutation? correct answer: The enzyme will not be able to form the transition state complex Hemoglobin has the ability to display cooperative binding while myo...

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