Common cyp inhibitors Study guides, Class notes & Summaries

Warfarin interactions - ANSWER-FLAMES o Fluconazole o Levofloxacin (really increase INR) o Amiodarone (worse interaction - decrease warfarin dose *by 50%*) o Metronidazole (decrease warfarin dose *by 1/3*) o Erythromycin (macrolides in general but this one is the worse) o Sulf-TMP CYP Inducers - ANSWER-PS PORCS o Phenytoin o Smoking o Phenobarbital o Oxcarbazepine (and eslicarbamazepine) o Rifampin o Carbamazepine (and its auto-inducer) o St. John's wort CYP Inhibitor...

CARDAIC – RENAL QUIZ ACE Inhibitors Angiotensin-converting enzyme (ACE) inhibitors help relax blood vessels. ACE inhibitors prevent an enzyme in your body from producing angiotensin II, a substance in your body that narrows your blood vessels and releases hormones that can raise your blood pressure. This narrowing can cause high blood pressure and force your heart to work harder. Ray has been diagnosed with hypertension and an angiotensin-converting enzyme inhibitor is determined to be need...

What are lipoproteins? - Answer--consist of various amounts of cholesterol, triglycerides, and phospholipids along with a protein carrier -classified according to their size, weight or density -not soluble in plasma, they must be specifically packaged for transport through the blood What is the main function of LDL? - Answer-transport cholesterol from liver to tissues What is the main function of HDL? - Answer-transport surplus cholesterol from tissues back to liver Where does cholesterol ...

Risk of Schizophrenia in monozygotic twins is? - ANSWER 46-50% Family hx risk of schizophrenia - ANSWER 10x risk with 1st degree relative brain changes in schizophrenia - ANSWER increase in ventricular volume (enlarged cerebral ventricles) Hippocampus volume decrease, 4% smaller Decreased electrical activity in frontal lobes Decrease glutamate and GABA release. Decreased total brain volume functional neuroimaging findings of schizophrenia - ANSWER Abnormal function of frontal corti...

CYP INHIBITORS - CORRECT ANSWER **G PACMAN** Grapefruit Protease inhibitors (Ritonavir) Azole antifungals C - cyclosporine, cimetidine, cobicistat Macrolides (NOT azithromycin) Amiodarone (and dronedarone) Non-DHP CCBs CYP INDUCERS - CORRECT ANSWER **PS PORCS** Phenytoin Smoking Phenobarbital Oxcarbazepine (and eslicarbazepine) Rifampin Carbamazepine (also auto-inducer) St. Johns wort Digoxin Levels - CORRECT ANSWER 0.8-2 (Afib) 0.5-0.9 (HF) Toxicity: ...

RXPREP: KEY DRUGS, MNEMONICS, STUDY TIPS1 • HAZARDOUS DRUGS are: o Teratogenic o Carcinogenic o Genotoxic (damage the DNA and can cause cancer) o Have reproductive toxicity o Cause organ toxicity at low doses • Key hazardous drugs that require SPECIAL HANDLING to avoid toxicity to workers: o All pregnancy category X drugs, category D’s and a few C’s, and paroxetine, methotrexate, misoprostol, mifepristone, ribavirin o Antineoplastics (chemotherapeutics) o 5-alpha reductase inh...

Frontier PC 707 Advanced Pharmacology Final Safety Exam Understand and identify evidenced-based prescribing resources - Answer ️️ -ACOG, American Ca Society, National lung and heart instituete, EEP, Dynamed, Lexicomp, Sanford guide, lactamed **NO PDR Understand PLLR: Drugs in Pregnancy and Lactation: Improved Benefit-Risk information. - Answer ️️ -June 2015; 3 sections pregnancy-L&D, Lactation-nursing mothers; Fe/males of reproductive age; labeling updated as new information arrive...

Pearl - Amide- vs. Ester-Type Anesthetics - Answer Amide-type anesthetics can be recognized by the "i" in their name before the"-caine" ending (e.g., lidocaine, bupivacaine, mepivacaine, ropivacaine). Ester-type anesthetics do not contain an "i" before the "-caine" ending (e.g., procaine, benzocaine, cocaine, tetracaine). Hypersensitivity to one type of drug in an anesthetic class, such as the ester-type procaine, does not confer cross-reactivity to drugs within the opposite anesth...

Mnemonics for NAPLEX (graded A+)already passed 2023Warfarin interactions - correct answer FLAMES o Fluconazole o Levofloxacin (really increase INR) o Amiodarone (worse interaction - decrease warfarin dose *by 50%*) o Metronidazole (decrease warfarin dose *by 1/3*) o Erythromycin (macrolides in general but this one is the worse) o Sulf-TMP CYP Inducers - correct answer PS PORCS o Phenytoin o Smoking o Phenobarbital o Oxcarbazepine (and eslicarbamazepine) o Rifampin o Carbama...

Frontier PC 707 Advanced Pharmacology Final Safety Exam Understand and identify evidenced-based prescribing resources - Answer ️️ -ACOG, American Ca Society, National lung and heart instituete, EEP, Dynamed, Lexicomp, Sanford guide, lactamed **NO PDR Understand PLLR: Drugs in Pregnancy and Lactation: Improved Benefit-Risk information. - Answer ️️ -June 2015; 3 sections pregnancy-L&D, Lactation-nursing mothers; Fe/males of reproductive age; labeling updated as new information arrive...