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Stroke is the ___ leading cause of death - ANSWER-5th
Only about ___ of stroke survivors get outpatient care in the US - ANSWER-1/3
Stroke - definition - ANSWER-Sudden loss of neurological function due to *interruption
of blood supply* to the brain
Stroke - 2 main types and frequencies - ANSWER-- *Ischemic Stroke* (87%):
BLOCKAGE (obstruction) of a vessel due to atherosclerosis; 2 types - thrombotic or
embolic
- *Hemorrhagic Stroke* (13)%): RUPTURED blood vessel; common sources: HTN,
aneurysm, AVM; 2 types - intracerebral or subarachnoid
Ischemic stroke - 2 types - ANSWER-- *Thrombotic* (80%) = primary clot
- *Embolic* (20%) = ineffective heart function (atrial fibrillation), heart valves,
atherosclerotic vessels, internal carotid dissection (due to trauma or genetics)
Ischemic stroke - pathophysiology (4) - ANSWER-1. Cessation of blood flow
2. O2 and glucose deprivation
3. Triggers ischemic cascade
4. Ischemic core neurons die within minutes --> cerebral infarction
Penumbra - defintion - ANSWER-- The fragile area surrounding the ischemic core
(where infarction occurs and neurons die)
,- Still salvageable and is the target of treatment / recovery
Hemorrhagic stroke - common causes of ruptured blood vessel (3) - ANSWER-1. HTN
2. Aneurysm
3. Arterial venous malformation (AVM) - congenital defect at junction of arterial and
venous junction that may leak or break
Hemorrhagic stroke - 2 types - ANSWER-- Intracerebral hemorrhage (ICH) (10%)
- Subarachnoid hemorrhage (SAH) (3%)
Hemorrhagic stroke - pathophysiology (4) - ANSWER-1. *Loss of blood supply distally*
--> same events as with an ischemic stroke
- Cessation of blood flow
- O2 and glucose deprivation
- Triggers ischemic cascade
- Ischemic core neurons die within minutes --> cerebral infarction
PLUS:
2. *Direct toxic effect* to tissue
3. *Tissue compression*
4. *Swelling*
CVA vs. TIA - ANSWER-- Neurological deficits must persist for *at least 24 hours* to be
considered a CVA
- A transient ischemic attack (TIA / "mini-stroke") results in similar deficits but *resolves
within 24 hours*; usually *no permanent brain damage, however increased risk of
stroke*
- TIA involves a temporary blockage of blood flow to the brain
,- About 15% of strokes are preceded by a TIA
Mortality based on stroke type - ANSWER-- Risk is *time dependent*
- Initial risk: 4x higher in hemorrhagic stroke
- After 1 week: 2.5x higher risk
- After 3 weeks: 1.5x higher risk
- By 3 months: NO difference b/t stroke types and mortality
Stroke - modifiable risk factors (*know 7*) - ANSWER-1. HTN
2. High cholesterol
3. Smoking
4. DM
5. Diet / nutrition
6. Inactivity
7. Obesity
- 1-7 are considered "Life's Simple 7" key health factors tracked by AHA
---
8. Heart disease
9. Peripheral artery disease
10. Atrial fibrillation (--> metabolic stroke)
Stroke - NON-modifiable risk factors (6) - ANSWER-1. Age (>60)
2. Sex (F > M)
3. Family hx / genetics
4. Prior hx of CVA, TIA or heart attack
, 5. Race (Black, Hispanic, Alaskan Native), Geography (South Eastern US)
6. Sickle cell anemia
Stroke - early warning signs (5) - ANSWER-All are *SUDDEN ONSET* "red flags"
1. *Numbness or weakness of the face, arm, or leg* especially on ONE side of the body
e.g. face drooping, one arm hanging down
2. *Confusion, trouble speaking, or understanding* e.g. slurred speech
3. *Vision changes / loss* - trouble seeing in one or both eyes
4. Trouble *walking, dizziness, lack of balance or coordination*
5. Severe *HA* with no known cause
BEFAST:
- Balance, HA, dizziness
- Eyes: vision, blurriness
- Face: 1 side drooping, numb
- Arms or legs weak and numb
- Speech difficulty, confusion
(Time to call 911)
Stroke - levels of care (6) - ANSWER-1. ED
2. ICU
3. Acute
4. Inpatient rehab facility (IRF) / 5. Subacute rehab - SNF or TCU
6. Outpatient, home health or community based settings