Aromatic Substitution

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Aromatic Substitution

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Aromatic Substitution Reactions Handout – Your Go-To Guide for EAS Mastery Nail electrophilic aromatic substitution (EAS) reactions with this clear, organized, and high-yield handout that breaks down one of Organic Chemistry’s most reaction-rich topics. What’s included: Step-by-step mechanism breakdowns for key EAS reactions: nitration, sulfonation, halogenation, Friedel-Crafts alkylation & acylation Activating vs. deactivating groups explained with real examples Ortho/para vs. meta directors and how to predict substitution patterns Summary chart of common substituents and their directing effects Practice problems with reaction predictions and full solutions Tips to avoid common mistakes in exam questions and synthesis problems Perfect for Organic Chemistry students preparing for exams, quizzes, or reaction mechanism reviews.

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1
Chapter 18 – Electrophilic Aromatic Substitution

Chapter 18 – Aromatic Substitution Reactions
Unexpected Bromination of Benzene

Electrophilic Aromatic Substitution

Me when I saw a mirror at the gym

, 2
Chapter 18 – Electrophilic Aromatic Substitution

Rxn1: Halogenation

Mechanism of the formation of Fe-Br complex

Mechanism of Bromination of Benzene

Me when I saw a mirror at the gym

, 3
Chapter 18 – Electrophilic Aromatic Substitution

This is the target

sincedenzene
Rxn2: Sulfonation are

Me when I saw a mirror at the gym

, 4
Chapter 18 – Electrophilic Aromatic Substitution

Rxn3: Nitration

= -1 4 pica
=
-3)stronger
pla
.

- 1
W
↑
: -1 7
pica
.

- 1
H
A ↳
4

under
acidic
Rxn3.1: Reduction of NO2 group condition

↓

Ammulinium On

Me when I saw a mirror at the gym

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Uploaded on: May 22, 2025
Number of pages: 33
Written in: 2024/2025
Type: Class notes
Professor(s): Pete punthasee
Contains: All classes

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