NR 565 Advanced Pharmacology
Final Exam Bank Chamberlain
Complete Guide 2026/ 2027 with
Verified Solutions
1. Who should receive Tdap vaccination?
Correct Answer: Adults in close contact with infants and
healthcare workers.
Explanation:
Tdap vaccination is recommended for adults who need
protection against tetanus, diphtheria, and pertussis. It is
particularly important for healthcare personnel and adults who
have close contact with infants because young infants are
highly vulnerable to severe pertussis complications.
Vaccination of close contacts helps reduce the likelihood of
transmitting pertussis to an infant.
2. What is a contraindication for the Tdap vaccine?
Correct Answer: A severe allergic reaction to a previous
dose or a history of encephalopathy within 7 days after a
pertussis-containing vaccine.
,Explanation:
A severe allergic reaction, such as anaphylaxis, following a
previous dose or to a vaccine component is a contraindication
to further administration of that vaccine. Encephalopathy
occurring within 7 days after a previous pertussis-containing
vaccine, when not attributable to another identifiable cause, is
also a contraindication to additional pertussis-containing
vaccines.
3. What are contraindications to the varicella vaccine?
Correct Answer: A history of anaphylaxis to a previous
dose or vaccine component, including certain components
such as gelatin or neomycin.
Explanation:
Varicella vaccine is a live attenuated vaccine. A severe
allergic reaction to a previous dose or a vaccine component is
a contraindication. Because varicella vaccine contains specific
vaccine components, individuals with a known severe allergy
to those components should not receive it. Live vaccines are
also generally contraindicated during pregnancy and in people
with certain forms of severe immunocompromise.
4. What are contraindications to the hepatitis B vaccine?
,Correct Answer: A previous severe allergic reaction to the
vaccine or a vaccine component, including yeast in certain
hepatitis B vaccine formulations.
Explanation:
Hepatitis B vaccines are recombinant vaccines rather than live
vaccines. The major contraindication is a severe allergic
reaction to a previous dose or to a component of the vaccine.
Many hepatitis B vaccine formulations are produced using
recombinant technology involving yeast, so a severe
hypersensitivity to yeast is clinically important when selecting
the vaccine product.
5. What are examples of attenuated vaccines?
Correct Answer: Measles, mumps, rubella, varicella, yellow
fever, and rotavirus vaccines.
Explanation:
Attenuated vaccines contain live organisms that have been
weakened so they generally produce an immune response
without causing disease in healthy individuals. Examples
include MMR, varicella, yellow fever, and rotavirus vaccines.
Because they contain live organisms, certain live attenuated
, vaccines are contraindicated in pregnancy and severe
immunocompromise.
6. What are examples of live vaccines?
Correct Answer: MMR, varicella, rotavirus, and live
attenuated influenza vaccine.
Explanation:
Live vaccines contain organisms capable of limited replication
in the recipient. The resulting immune response can closely
resemble natural infection. Examples include MMR, varicella,
rotavirus, yellow fever, and the live attenuated intranasal
influenza vaccine. Live vaccines have specific
contraindications and precautions that differ from those of
inactivated vaccines.
7. What are examples of toxoid vaccines?
Correct Answer: Diphtheria and tetanus vaccines.
Explanation:
Toxoid vaccines are made from bacterial toxins that have been
chemically or otherwise inactivated so they cannot cause their
toxic effects but can still stimulate protective immunity.
Tetanus and diphtheria vaccines are classic examples.
Final Exam Bank Chamberlain
Complete Guide 2026/ 2027 with
Verified Solutions
1. Who should receive Tdap vaccination?
Correct Answer: Adults in close contact with infants and
healthcare workers.
Explanation:
Tdap vaccination is recommended for adults who need
protection against tetanus, diphtheria, and pertussis. It is
particularly important for healthcare personnel and adults who
have close contact with infants because young infants are
highly vulnerable to severe pertussis complications.
Vaccination of close contacts helps reduce the likelihood of
transmitting pertussis to an infant.
2. What is a contraindication for the Tdap vaccine?
Correct Answer: A severe allergic reaction to a previous
dose or a history of encephalopathy within 7 days after a
pertussis-containing vaccine.
,Explanation:
A severe allergic reaction, such as anaphylaxis, following a
previous dose or to a vaccine component is a contraindication
to further administration of that vaccine. Encephalopathy
occurring within 7 days after a previous pertussis-containing
vaccine, when not attributable to another identifiable cause, is
also a contraindication to additional pertussis-containing
vaccines.
3. What are contraindications to the varicella vaccine?
Correct Answer: A history of anaphylaxis to a previous
dose or vaccine component, including certain components
such as gelatin or neomycin.
Explanation:
Varicella vaccine is a live attenuated vaccine. A severe
allergic reaction to a previous dose or a vaccine component is
a contraindication. Because varicella vaccine contains specific
vaccine components, individuals with a known severe allergy
to those components should not receive it. Live vaccines are
also generally contraindicated during pregnancy and in people
with certain forms of severe immunocompromise.
4. What are contraindications to the hepatitis B vaccine?
,Correct Answer: A previous severe allergic reaction to the
vaccine or a vaccine component, including yeast in certain
hepatitis B vaccine formulations.
Explanation:
Hepatitis B vaccines are recombinant vaccines rather than live
vaccines. The major contraindication is a severe allergic
reaction to a previous dose or to a component of the vaccine.
Many hepatitis B vaccine formulations are produced using
recombinant technology involving yeast, so a severe
hypersensitivity to yeast is clinically important when selecting
the vaccine product.
5. What are examples of attenuated vaccines?
Correct Answer: Measles, mumps, rubella, varicella, yellow
fever, and rotavirus vaccines.
Explanation:
Attenuated vaccines contain live organisms that have been
weakened so they generally produce an immune response
without causing disease in healthy individuals. Examples
include MMR, varicella, yellow fever, and rotavirus vaccines.
Because they contain live organisms, certain live attenuated
, vaccines are contraindicated in pregnancy and severe
immunocompromise.
6. What are examples of live vaccines?
Correct Answer: MMR, varicella, rotavirus, and live
attenuated influenza vaccine.
Explanation:
Live vaccines contain organisms capable of limited replication
in the recipient. The resulting immune response can closely
resemble natural infection. Examples include MMR, varicella,
rotavirus, yellow fever, and the live attenuated intranasal
influenza vaccine. Live vaccines have specific
contraindications and precautions that differ from those of
inactivated vaccines.
7. What are examples of toxoid vaccines?
Correct Answer: Diphtheria and tetanus vaccines.
Explanation:
Toxoid vaccines are made from bacterial toxins that have been
chemically or otherwise inactivated so they cannot cause their
toxic effects but can still stimulate protective immunity.
Tetanus and diphtheria vaccines are classic examples.
