NR 507 - Week 3 Quiz. Questions & Answers.

The underlying disorder of anemia is defective secretion of intrinsic factor, which is essential for the absorption of vitamin B12. pernicious PA, the most common type of megaloblastic anemia, is caused by vitamin B12 deficiency. Symptoms of polycythemia vera are mainly the result of increased blood viscosity. As the disease progresses many of the symptoms are related to the increased blood cellularity and viscosity. In hemolytic anemia, jaundice occurs only when heme destruction exceeds the liver’s ability to conjugate and excrete bilirubin. Jaundice (icterus) is present when heme destruction exceeds the liver’s ability to conjugate and excrete bilirubin. Which anemia produces small, pale erythrocytes? Iron deficiency The microcytic-hypochromic anemias, which include iron deficiency anemia (IDA), are characterized by erythrocytes that are abnormally small and contain abnormally reduced amounts of hemoglobin. Pernicious anemia generally requires continued therapy lasting the rest of one’s life. PA cannot be cured, so maintenance therapy is lifelong. A woman complains of chronic gastritis, fatigue, weight loss, and tingling in her fingers. Laboratory findings show low hemoglobin and hematocrit levels, and a high mean corpuscular volume. These findings are consistent with anemia pernicious Gastric atrophy commonly occurs in the presence of type A chronic gastritis and may be autoimmune. Autoantibodies against gastric parietal cells are frequently observed. When the hemoglobin level in the blood has decreased significantly (7 to 8 g/dl), the individual experiences the classic symptoms of anemia—weakness, fatigue, paresthesias of the feet and fingers, difficulty in walking, loss of appetite, abdominal pains, and weight loss. Which proinflammatory cytokines are responsible for the development and maintenance of DIC? TNF-α; IL-1, IL-6, and IL-8; and PAF Endotoxin, in particular, triggers the release of multiple cytokines that play a significant role in the development and maintenance of DIC. Proinflammatory cytokines (TNF-α; IL-1, IL-6, IL-8; and PAF) are responsible for the clinical signs and symptoms associated with sepsis. Which of the following is a description consistent with chronic lymphocytic leukemia (CLL)? There is failure of B cells to mature into plasma cells that synthesize immunoglobulins. Thus CLL is derived from transformation of a partially mature B cell that has not yet encountered antigen. What change is seen in leukocytes during an allergic disorder (type I) often caused by asthma, hay fever, and drug reactions? Eosinophilia Allergic disorders (type I hypersensitivity) associated with asthma, hay fever, and drug reactions, as well as parasitic infections (particularly with metazoal parasites) are often cited as causes. What is the most common cause of The most common cause of vitamin K