1|Page
NR 507 EDAPT ENDOCRINE SYSTEM EXAM
PREP 2026 | ALL QUESTIONS AND
CORRECT DETAILED ANSWERS |
ALREADY A GRADED | NEW AND REVISED
1. A 45-year-old female presents with heat intolerance, palpitations,
and weight loss despite increased appetite. Lab results show
decreased TSH and elevated free T4. What is the most likely
diagnosis?
A. Hypothyroidism
B. Hyperthyroidism (Graves’ disease)
C. Thyroid storm
D. Hashimoto’s thyroiditis
Suppressed TSH with elevated T4 indicates primary hyperthyroidism;
Graves’ is the most common cause in adults.
2. A patient presents with polyuria, polydipsia, and hyperglycemia.
Which type of diabetes is most consistent with these findings?
A. Type 2 diabetes
B. Gestational diabetes
C. Type 1 diabetes mellitus
D. Secondary diabetes
Polyuria, polydipsia, and weight loss in a young adult suggest
autoimmune destruction of beta cells consistent with Type 1 diabetes.
3. Which hormone deficiency is responsible for Addison’s disease?
A. Thyroxine
,2|Page
B. Growth hormone
C. Cortisol and aldosterone
D. Insulin
Addison’s disease is primary adrenal insufficiency causing deficiency
of glucocorticoids (cortisol) and mineralocorticoids (aldosterone).
4. A patient presents with sudden, severe headache, visual
disturbances, and hypotension. Lab shows low cortisol and ACTH
deficiency. Which endocrine emergency is most likely?
A. Thyroid storm
B. Diabetic ketoacidosis
C. Acute adrenal crisis
D. Pheochromocytoma crisis
Acute adrenal crisis presents with hypotension, shock, and cortisol
deficiency; it’s life-threatening.
5. A patient with type 2 diabetes reports fatigue, weight gain, and
cold intolerance. TSH is elevated and free T4 is low. What is the
most likely diagnosis?
A. Hyperthyroidism
B. Subclinical hypothyroidism
C. Primary hypothyroidism
D. Pituitary adenoma
Elevated TSH with low free T4 indicates primary hypothyroidism.
6. A 35-year-old male presents with moon face, central obesity, and
hypertension. Labs show elevated cortisol. Which is the most likely
diagnosis?
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A. Addison’s disease
B. Hypopituitarism
C. Cushing’s syndrome
D. Hyperaldosteronism
Characteristic features of Cushing’s syndrome include
hypercortisolism, moon face, and central obesity.
7. Which lab test is most useful in monitoring long-term glycemic
control in diabetes?
A. Fasting glucose
B. Random glucose
C. Hemoglobin A1C
D. Serum insulin
HbA1c reflects average blood glucose over 2–3 months.
8. A patient with newly diagnosed Graves’ disease presents with
palpitations, tremors, and anxiety. Which medication is first-line for
symptom control?
A. Methimazole
B. Beta-blocker (e.g., propranolol)
C. Levothyroxine
D. Corticosteroids
Beta-blockers control sympathetic symptoms while definitive therapy
(antithyroid drugs, RAI) is initiated.
9. Which of the following is the hallmark of diabetes insipidus?
A. Hyperglycemia
B. Hypotension
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C. Polyuria and polydipsia with dilute urine
D. Hyperkalemia
Diabetes insipidus causes polyuria and polydipsia due to ADH
deficiency or resistance.
10. Which of the following is a primary cause of
hyperparathyroidism?
A. Chronic kidney disease
B. Vitamin D deficiency
C. Parathyroid adenoma
D. Hypomagnesemia
Primary hyperparathyroidism is most often caused by a parathyroid
adenoma.
11. A patient with type 1 diabetes presents with nausea, vomiting,
abdominal pain, and rapid deep breathing. Glucose is 480 mg/dL,
pH 7.1. What is the likely diagnosis?
A. Hyperosmolar hyperglycemic state
B. Hypoglycemia
C. Diabetic ketoacidosis (DKA)
D. Lactic acidosis
DKA is characterized by hyperglycemia, acidosis, ketonemia, and
Kussmaul respirations.
12. Which of the following lab findings is most consistent with
SIADH?
A. Hypernatremia
B. Hyponatremia with low serum osmolality
NR 507 EDAPT ENDOCRINE SYSTEM EXAM
PREP 2026 | ALL QUESTIONS AND
CORRECT DETAILED ANSWERS |
ALREADY A GRADED | NEW AND REVISED
1. A 45-year-old female presents with heat intolerance, palpitations,
and weight loss despite increased appetite. Lab results show
decreased TSH and elevated free T4. What is the most likely
diagnosis?
A. Hypothyroidism
B. Hyperthyroidism (Graves’ disease)
C. Thyroid storm
D. Hashimoto’s thyroiditis
Suppressed TSH with elevated T4 indicates primary hyperthyroidism;
Graves’ is the most common cause in adults.
2. A patient presents with polyuria, polydipsia, and hyperglycemia.
Which type of diabetes is most consistent with these findings?
A. Type 2 diabetes
B. Gestational diabetes
C. Type 1 diabetes mellitus
D. Secondary diabetes
Polyuria, polydipsia, and weight loss in a young adult suggest
autoimmune destruction of beta cells consistent with Type 1 diabetes.
3. Which hormone deficiency is responsible for Addison’s disease?
A. Thyroxine
,2|Page
B. Growth hormone
C. Cortisol and aldosterone
D. Insulin
Addison’s disease is primary adrenal insufficiency causing deficiency
of glucocorticoids (cortisol) and mineralocorticoids (aldosterone).
4. A patient presents with sudden, severe headache, visual
disturbances, and hypotension. Lab shows low cortisol and ACTH
deficiency. Which endocrine emergency is most likely?
A. Thyroid storm
B. Diabetic ketoacidosis
C. Acute adrenal crisis
D. Pheochromocytoma crisis
Acute adrenal crisis presents with hypotension, shock, and cortisol
deficiency; it’s life-threatening.
5. A patient with type 2 diabetes reports fatigue, weight gain, and
cold intolerance. TSH is elevated and free T4 is low. What is the
most likely diagnosis?
A. Hyperthyroidism
B. Subclinical hypothyroidism
C. Primary hypothyroidism
D. Pituitary adenoma
Elevated TSH with low free T4 indicates primary hypothyroidism.
6. A 35-year-old male presents with moon face, central obesity, and
hypertension. Labs show elevated cortisol. Which is the most likely
diagnosis?
,3|Page
A. Addison’s disease
B. Hypopituitarism
C. Cushing’s syndrome
D. Hyperaldosteronism
Characteristic features of Cushing’s syndrome include
hypercortisolism, moon face, and central obesity.
7. Which lab test is most useful in monitoring long-term glycemic
control in diabetes?
A. Fasting glucose
B. Random glucose
C. Hemoglobin A1C
D. Serum insulin
HbA1c reflects average blood glucose over 2–3 months.
8. A patient with newly diagnosed Graves’ disease presents with
palpitations, tremors, and anxiety. Which medication is first-line for
symptom control?
A. Methimazole
B. Beta-blocker (e.g., propranolol)
C. Levothyroxine
D. Corticosteroids
Beta-blockers control sympathetic symptoms while definitive therapy
(antithyroid drugs, RAI) is initiated.
9. Which of the following is the hallmark of diabetes insipidus?
A. Hyperglycemia
B. Hypotension
, 4|Page
C. Polyuria and polydipsia with dilute urine
D. Hyperkalemia
Diabetes insipidus causes polyuria and polydipsia due to ADH
deficiency or resistance.
10. Which of the following is a primary cause of
hyperparathyroidism?
A. Chronic kidney disease
B. Vitamin D deficiency
C. Parathyroid adenoma
D. Hypomagnesemia
Primary hyperparathyroidism is most often caused by a parathyroid
adenoma.
11. A patient with type 1 diabetes presents with nausea, vomiting,
abdominal pain, and rapid deep breathing. Glucose is 480 mg/dL,
pH 7.1. What is the likely diagnosis?
A. Hyperosmolar hyperglycemic state
B. Hypoglycemia
C. Diabetic ketoacidosis (DKA)
D. Lactic acidosis
DKA is characterized by hyperglycemia, acidosis, ketonemia, and
Kussmaul respirations.
12. Which of the following lab findings is most consistent with
SIADH?
A. Hypernatremia
B. Hyponatremia with low serum osmolality
