PCEUT

oral bioavialability (F) - Answer the fraction of an orally administered dose of drug that reaches systemic circulation unchanged F = (bioavailable dose)/(oral dose) describes the extent to which a drug is absorbed from GI tract into systemic circulation factors decreasing oral bioavailability - Answer GI tract: - drug solubility - permeability across gut wall - interaction w/ gut metabolic enzymes and transporters Liver: - first pass effect What pharmacokinetic quantity ...