What factor is deficient in Hemophilia A?
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Factor VIII
What diseases are included in inherited coagulation disorders?
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Hemophilia, von Willebrand disease
Why is low von Willebrand factor an issue? What are its effects on factor VIII?
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If it is low, there will be impaired formation of the platelet plug. Also vWF is
bound to inactive factor VIII in circulation to keep it from degrading
prematurely. In von Willebrand disease, we can expect low factor VIII as
well due to early degradation.
Why might acute myeloid leukaemia cause thrombocytopenia?
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The cancerous cells will be in the bone marrow and proliferate, leading to
overcrowding and a decrease in the production of needed blood cells
such as platelets.
What is the Virchows triad?
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Abnormal blood flow- Stasis or turbulence allow the platelets to come in
contact with endothelium or clotting factors exceed their needed
concentration.
Endothelial injury- Collagen and tissue factor is exposed allowing platelet
adhesion and clotting cascade activation.
Hyper-coagulability- A greater tendency to form clots.
What are conditions or factors causing clotting factor deficiency? (4)
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Give this one a try later!
Factor VIII
What diseases are included in inherited coagulation disorders?
Give this one a try later!
Hemophilia, von Willebrand disease
Why is low von Willebrand factor an issue? What are its effects on factor VIII?
, Give this one a try later!
If it is low, there will be impaired formation of the platelet plug. Also vWF is
bound to inactive factor VIII in circulation to keep it from degrading
prematurely. In von Willebrand disease, we can expect low factor VIII as
well due to early degradation.
Why might acute myeloid leukaemia cause thrombocytopenia?
Give this one a try later!
The cancerous cells will be in the bone marrow and proliferate, leading to
overcrowding and a decrease in the production of needed blood cells
such as platelets.
What is the Virchows triad?
Give this one a try later!
Abnormal blood flow- Stasis or turbulence allow the platelets to come in
contact with endothelium or clotting factors exceed their needed
concentration.
Endothelial injury- Collagen and tissue factor is exposed allowing platelet
adhesion and clotting cascade activation.
Hyper-coagulability- A greater tendency to form clots.
What are conditions or factors causing clotting factor deficiency? (4)
Give this one a try later!
