OB/GYN EORE Infections (Internal Medicine) | 20+ Questions | Vaginitis, PID, STIs, Syphilis, HSV | 2025/2026

This expertly verified guide offers 20+ concise flashcard-style questions and answers focused on infectious diseases in obstetrics and gynecology, specifically curated for the OB/GYN End-of-Rotation Exam (EORE) in the 2025/2026 academic year. It covers high-yield vaginal infections, sexually transmitted infections (STIs), and reproductive tract inflammatory disorders with clear diagnostic clues and treatment protocols. Vaginitis types are clearly differentiated: Trichomoniasis: frothy yellow-green discharge, “strawberry cervix,” motile protozoa on wet mount, treated with a single 2g oral dose of metronidazole Bacterial vaginosis (BV): fishy odor, clue cells on wet mount, gray discharge, treated with metronidazole Candidiasis: thick white discharge, pseudohyphae on KOH, associated with diabetes, recent antibiotics, treated with fluconazole Atrophic vaginitis: estrogen deficiency leading to dryness, itching, dyspareunia, and managed with lubricants or topical estrogen Cervicitis and STIs: Most often caused by Chlamydia trachomatis and Neisseria gonorrhoeae May present with intermenstrual or postcoital bleeding, or be asymptomatic Treated with ceftriaxone or cefixime for gonorrhea, doxycycline or azithromycin for chlamydia (or erythromycin in pregnancy) HSV-2 leads to ulcerative lesions, treated with acyclovir HPV (types 6, 11, 16, 18) causes warts and cervical dysplasia, preventable with HPV vaccine Pelvic Inflammatory Disease (PID): Caused by ascending infection (often GC/Chlamydia or IUD-related) Symptoms: bilateral lower abdominal pain, cervical motion tenderness (chandelier sign), fever, and purulent discharge Complications: infertility, ectopic pregnancy, tubo-ovarian abscess Diagnosis via transvaginal ultrasound, DNA probe, or laparoscopy Syphilis: Primary: painless chancre Secondary: rash on palms/soles Tertiary: neurosyphilis, tabes dorsalis, aortic aneurysm Diagnosis: dark field microscopy, VDRL/RPR Treatment: IM benzathine penicillin G May trigger Jarisch-Herxheimer reaction within 24 hours (fever, myalgia) Other STIs included: Chancroid: painful genital ulcer caused by Haemophilus ducreyi, treated with azithromycin or ceftriaxone Lymphogranuloma venereum (LGV): caused by Chlamydia trachomatis, presents as painful inguinal lymphadenopathy following unnoticed lesion, may require aspiration if abscessed Best suited for: PA students preparing for OB/GYN EORE or reproductive infectious disease modules Medical students (MD/DO) studying for NBME shelf or USMLE Step 2 NP and nursing students in women’s health clinical rotations COMLEX and PANCE candidates reviewing infectious causes of reproductive tract pathology Keywords: trichomoniasis, bacterial vaginosis, candidiasis, atrophic vaginitis, cervicitis, chlamydia, gonorrhea, HSV-2, PID, chandelier sign, syphilis stages, RPR, VDRL, Jarisch-Herxheimer, chancroid, Haemophilus ducreyi, lymphogranuloma venereum, LGV, HPV vaccine, wet mount, STI treatment, vaginal infections