ASCP HEMATOLOGY REVIEW | 250
QUESTIONS/EXAM QUESTIONS AND
ANSWERS 100% VERIFIED.
Name the locations of active marrow in adults: - correct answer
sternum, skull, ribs, pelvis, vertebrae
Where does hematopoiesis take place during the first 2 months
of gestation? - correct answer
yolk sac
Where does the majority of hematopoiesis take place during
the 2nd through 7th month of gestation? - correct answer
spleen
When does the bone marrow take over hematopoiesis? -
correct answer
after birth
What are the stages in order of the erythrocyte lineage? -
correct answer
(1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte,
(5)reticulocyte, (6)erytrocyte
What are the stages in order of the granulocyte (neutrophil,
eosinophil, basophil) lineage? - correct answer
(1)myeloblast, (2)promyelocyte, (3)myelocyte,
(4)metamyelocyte, (5)band, (6)segmented (7)eos/baso
,What are the stages in order of the macrophage lineage? -
correct answer
(1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage
What are the stages in order of the platelet lineage? - correct
answer
(1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte,
(4)platelet
What are the stages in order of the lymphocyte lineage? -
correct answer
(1)lymphoblast, (2)prolymphocyte, (3)lymphocyte
Which growth factors stimulate the erythrocyte lineage? -
correct answer
GM-CSF, EPO, IL-3
Which growth factors stimulate the granulocyte lineages? -
correct answer
GM-CSF, IL-3
Which growth factors stimulate the platelet lineage? - correct
answer
GM-CSF, IL-3, TPO
Which growth factors stimulate the lymphocyte lineage? -
correct answer
,IL-2, IL-4, IL-6, IL-7
Which protein functions in the transport of Fe? - correct
answer
transferrin
What is the major storage form of Fe? - correct answer
ferritin
What is the long-term (H20) insoluble Fe storage form called? -
correct answer
hemosiderin
Excess Iron is stored where? What does this cause? - correct
answer
tissues and body organs, hemosiderosis, hemochromatosis
Porphyrias are attributed to? - correct answer
excessive formation of porphrins due to blockages in any
enzymatic step in the heme synthesis pathway.
Red or port wine colored urine can be seen in which condition
related to the build up of heme precursors? - correct answer
porphyria
Neuropsychiatirc symptoms are seen when a build up of which
precursors occurs? - correct answer
early precursors (Delta-aminolevulinic acid/Porphobilinogen)
, Cutaneous symptoms such as photo-sensitivity and facial hair
are seen when a build up of which precursors occurs? - correct
answer
later precursors (uroporphyrinogen/coproporphyrinogen,
protoporphyrin/heme)
Synthesis of heme requires what two components? - correct
answer
iron, protoporphyrin
What are the heme precursors in order of synthesis? - correct
answer
(1)delta-aminolevulinic acid, (2)porphobilinogen,
(3)uroporphyrinogen, (4)coproporphyrinogen,
(5)protoporphyrin, (6)heme
What type of hemoglobin is seen primarily in newborns? -
correct answer
Hgb F
What type of hemoglobin is seen primarily in adults? - correct
answer
Hgb A2
What type of hemoglobin is rarely seen in adults as well as
newborns? - correct answer
Hgb A
QUESTIONS/EXAM QUESTIONS AND
ANSWERS 100% VERIFIED.
Name the locations of active marrow in adults: - correct answer
sternum, skull, ribs, pelvis, vertebrae
Where does hematopoiesis take place during the first 2 months
of gestation? - correct answer
yolk sac
Where does the majority of hematopoiesis take place during
the 2nd through 7th month of gestation? - correct answer
spleen
When does the bone marrow take over hematopoiesis? -
correct answer
after birth
What are the stages in order of the erythrocyte lineage? -
correct answer
(1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte,
(5)reticulocyte, (6)erytrocyte
What are the stages in order of the granulocyte (neutrophil,
eosinophil, basophil) lineage? - correct answer
(1)myeloblast, (2)promyelocyte, (3)myelocyte,
(4)metamyelocyte, (5)band, (6)segmented (7)eos/baso
,What are the stages in order of the macrophage lineage? -
correct answer
(1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage
What are the stages in order of the platelet lineage? - correct
answer
(1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte,
(4)platelet
What are the stages in order of the lymphocyte lineage? -
correct answer
(1)lymphoblast, (2)prolymphocyte, (3)lymphocyte
Which growth factors stimulate the erythrocyte lineage? -
correct answer
GM-CSF, EPO, IL-3
Which growth factors stimulate the granulocyte lineages? -
correct answer
GM-CSF, IL-3
Which growth factors stimulate the platelet lineage? - correct
answer
GM-CSF, IL-3, TPO
Which growth factors stimulate the lymphocyte lineage? -
correct answer
,IL-2, IL-4, IL-6, IL-7
Which protein functions in the transport of Fe? - correct
answer
transferrin
What is the major storage form of Fe? - correct answer
ferritin
What is the long-term (H20) insoluble Fe storage form called? -
correct answer
hemosiderin
Excess Iron is stored where? What does this cause? - correct
answer
tissues and body organs, hemosiderosis, hemochromatosis
Porphyrias are attributed to? - correct answer
excessive formation of porphrins due to blockages in any
enzymatic step in the heme synthesis pathway.
Red or port wine colored urine can be seen in which condition
related to the build up of heme precursors? - correct answer
porphyria
Neuropsychiatirc symptoms are seen when a build up of which
precursors occurs? - correct answer
early precursors (Delta-aminolevulinic acid/Porphobilinogen)
, Cutaneous symptoms such as photo-sensitivity and facial hair
are seen when a build up of which precursors occurs? - correct
answer
later precursors (uroporphyrinogen/coproporphyrinogen,
protoporphyrin/heme)
Synthesis of heme requires what two components? - correct
answer
iron, protoporphyrin
What are the heme precursors in order of synthesis? - correct
answer
(1)delta-aminolevulinic acid, (2)porphobilinogen,
(3)uroporphyrinogen, (4)coproporphyrinogen,
(5)protoporphyrin, (6)heme
What type of hemoglobin is seen primarily in newborns? -
correct answer
Hgb F
What type of hemoglobin is seen primarily in adults? - correct
answer
Hgb A2
What type of hemoglobin is rarely seen in adults as well as
newborns? - correct answer
Hgb A
