ANCC Exam Questions Part 2 – Latest 2025
Exam Prep & Practice Set
Several pediatric patients who all attend the same childcare center have presented with
a pruritic rash and irregular lines of excoriation on their wrists within the past week. The
nurse practitioner wants to provide education to both the staff and parents to decrease
the risk of spreading the rash to other children. Which of the following is the most likely
source of the children's symptoms?
A.
Hand, foot, and mouth disease
Incorrect
B.
Pediculosis
Incorrect
C.
Roseola infantum
Incorrect
D.
Scabies - correct answerScabies
A 35-year-old woman presents to the clinic with dyspepsia and epigastric fullness. She
has been taking omeprazole (Prilosec) with mild improvement in her symptoms. Which
additional finding would warrant urgent upper endoscopy?
A.
Hoarseness
Incorrect
B.
Iron deficiency anemia
Correct
C.
Substernal chest pain
Incorrect
D.
Unexplained weight gain - correct answerIron deficiency anemia
A 62-year-old woman presents to the office with worsening scalp tenderness on the left
side of her head, double vision, and pain with chewing that started about 2 days ago.
The physical exam reveals a tender and enlarged left temporal artery. Which of the
following is the most appropriate treatment for the suspected diagnosis?
A.
Aspirin
Incorrect
,B.
Methotrexate (Trexall)
Incorrect
C.
NSAIDs
Incorrect
D.
Prednisone - correct answerPrednisone
A 73-year-old man with a history of moderate cognitive impairment returns to the clinic
with his daughter due to worsening memory loss. The patient's daughter reports
significant progression of symptoms since the last visit, which was 1 year ago. She says
that he recently mistook her for an intruder and threw a coffee mug at her. Additionally,
he became lost while driving, which resulted in an accident. He is becoming more
withdrawn and agitated, and he also struggles to use utensils. His Mini-Mental Status
Examination score is 10/30, and MRI shows generalized parenchymal volume loss.
Neuropsychological evaluation is pending. Which of the following is the most likely
diagnosis?
A.
Alzheimer disease
Correct
B.
Dementia with Lewy bodies
Incorrect
C.
Frontotemporal dementia
Incorrect
D.
Parkinson disease - correct answerAlzheimer disease
A 26-year-old man presents with right testicular pain. There is tenderness and swelling
with palpation of the right epididymis. He reports having vaginal intercourse with two
women in the past month and states that he has not engaged in any insertive anal
intercourse. Urinalysis of a first-void urine specimen was positive for leukocyte esterase.
The urine culture and tests for gonorrhea and chlamydia are pending. U/S does not
indicate testicular torsion. Which of the following treatments should be prescribed for
this patient?
A.
Ceftriaxone 500 mg IM given as a single dose and doxycycline (Vibramycin) 100 mg
orally twice daily for 10 days
Correct
B.
Ceftriaxone 500 mg IM given as a single dose and levofloxacin (Levaquin) 500 mg
orally twice daily for 10 days
Incorrect
C.
,Levofloxacin (Levaquin) 500 mg orally once daily for 10 days
Incorrect
D.
Ofloxacin 300 mg orally twice daily for 10 days - correct answerCeftriaxone 500 mg IM
given as a single dose and doxycycline (Vibramycin) 100 mg orally twice daily for 10
days
A 54-year-old man with a history of diabetes mellitus presents with redness, pain, and
swelling of his left lower extremity. Examination shows a 15 cm x 7 cm area of
nonfluctuant, nonelevated erythema and swelling over the anterior aspect of the left
lower extremity. He also has scaling and erythema between his toes, consistent with a
fungal infection. Which of the following is the most likely diagnosis?
A.
Cellulitis
Correct
B.
Erysipelas
Incorrect
C.
Impetigo
Incorrect
D.
Stasis dermatitis - correct answerCellulitis
A 53-year-old man presents to the clinic to establish care. He recently had labs
performed at a local health fair and was told to seek care for an elevated hemoglobin
level. He has been experiencing intense itching after showering and reports that his
cheeks have been redder than usual. Physical exam reveals a ruddy appearance of the
cheeks and mild excoriations on the arms and legs. Laboratory results reveal
hemoglobin of 19 g/dL, hematocrit of 58%, and a platelet count of 662,000/mcL. Which
of the following is the most likely diagnosis?
A.
Anemia of chronic disease
Incorrect
B.
Myelodysplastic syndrome
Incorrect
C.
Polycythemia vera
Correct
D.
Thrombocytopenia - correct answerPolycythemia vera
Which of the following laboratory results is consistent with Addison disease?
A.
Decreased adrenocorticotropic hormone and cortisol levels
, Incorrect
B.
Decreased adrenocorticotropic hormone levels and increased cortisol levels
Incorrect
C.
Increased adrenocorticotropic hormone and cortisol levels
Incorrect
D.
Increased adrenocorticotropic hormone levels and decreased cortisol levels - correct
answerIncreased adrenocorticotropic hormone levels and decreased cortisol levels
A 77-year-old man presents to the clinic with a fever and a productive cough for 2 days.
He reports tan sputum. He has a history of diabetes mellitus and chronic kidney
disease. His temperature is 100°F, and his oxygen saturation is 93% on room air. On
physical exam, the nurse practitioner auscultates crackles in the left lower lobe. Which
of the following is the best treatment regimen for this patient?
A.
Amoxicillin-clavulanate (Augmentin) 875-125 mg orally twice daily for 5 days
Incorrect
B.
Azithromycin (Zithromax) 500 mg orally on day one and then 250 mg orally once daily
for 4 days
Incorrect
C.
Doxycycline (Vibramycin) 100 mg orally twice daily for 5 days
Incorrect
D.
Levofloxacin (Levaquin) 750 mg orally once daily for 5 days - correct
answerLevofloxacin (Levaquin) 750 mg orally once daily for 5 days
A 17-year-old boy presents with lesions on his feet accompanied by intense pruritus and
pain. They have been present for 2 weeks, and he reports no history of allergies or
trauma. On physical examination, his vital signs are within normal limits, and the skin
examination is notable for erythematous erosions and scales between the toes of both
feet. There are also some interdigital fissures seen. Which of the following is the most
likely diagnosis?
A.
Candida infection
Incorrect
B.
Erythrasma
Incorrect
C.
Palmoplantar psoriasis
Incorrect
D.
Exam Prep & Practice Set
Several pediatric patients who all attend the same childcare center have presented with
a pruritic rash and irregular lines of excoriation on their wrists within the past week. The
nurse practitioner wants to provide education to both the staff and parents to decrease
the risk of spreading the rash to other children. Which of the following is the most likely
source of the children's symptoms?
A.
Hand, foot, and mouth disease
Incorrect
B.
Pediculosis
Incorrect
C.
Roseola infantum
Incorrect
D.
Scabies - correct answerScabies
A 35-year-old woman presents to the clinic with dyspepsia and epigastric fullness. She
has been taking omeprazole (Prilosec) with mild improvement in her symptoms. Which
additional finding would warrant urgent upper endoscopy?
A.
Hoarseness
Incorrect
B.
Iron deficiency anemia
Correct
C.
Substernal chest pain
Incorrect
D.
Unexplained weight gain - correct answerIron deficiency anemia
A 62-year-old woman presents to the office with worsening scalp tenderness on the left
side of her head, double vision, and pain with chewing that started about 2 days ago.
The physical exam reveals a tender and enlarged left temporal artery. Which of the
following is the most appropriate treatment for the suspected diagnosis?
A.
Aspirin
Incorrect
,B.
Methotrexate (Trexall)
Incorrect
C.
NSAIDs
Incorrect
D.
Prednisone - correct answerPrednisone
A 73-year-old man with a history of moderate cognitive impairment returns to the clinic
with his daughter due to worsening memory loss. The patient's daughter reports
significant progression of symptoms since the last visit, which was 1 year ago. She says
that he recently mistook her for an intruder and threw a coffee mug at her. Additionally,
he became lost while driving, which resulted in an accident. He is becoming more
withdrawn and agitated, and he also struggles to use utensils. His Mini-Mental Status
Examination score is 10/30, and MRI shows generalized parenchymal volume loss.
Neuropsychological evaluation is pending. Which of the following is the most likely
diagnosis?
A.
Alzheimer disease
Correct
B.
Dementia with Lewy bodies
Incorrect
C.
Frontotemporal dementia
Incorrect
D.
Parkinson disease - correct answerAlzheimer disease
A 26-year-old man presents with right testicular pain. There is tenderness and swelling
with palpation of the right epididymis. He reports having vaginal intercourse with two
women in the past month and states that he has not engaged in any insertive anal
intercourse. Urinalysis of a first-void urine specimen was positive for leukocyte esterase.
The urine culture and tests for gonorrhea and chlamydia are pending. U/S does not
indicate testicular torsion. Which of the following treatments should be prescribed for
this patient?
A.
Ceftriaxone 500 mg IM given as a single dose and doxycycline (Vibramycin) 100 mg
orally twice daily for 10 days
Correct
B.
Ceftriaxone 500 mg IM given as a single dose and levofloxacin (Levaquin) 500 mg
orally twice daily for 10 days
Incorrect
C.
,Levofloxacin (Levaquin) 500 mg orally once daily for 10 days
Incorrect
D.
Ofloxacin 300 mg orally twice daily for 10 days - correct answerCeftriaxone 500 mg IM
given as a single dose and doxycycline (Vibramycin) 100 mg orally twice daily for 10
days
A 54-year-old man with a history of diabetes mellitus presents with redness, pain, and
swelling of his left lower extremity. Examination shows a 15 cm x 7 cm area of
nonfluctuant, nonelevated erythema and swelling over the anterior aspect of the left
lower extremity. He also has scaling and erythema between his toes, consistent with a
fungal infection. Which of the following is the most likely diagnosis?
A.
Cellulitis
Correct
B.
Erysipelas
Incorrect
C.
Impetigo
Incorrect
D.
Stasis dermatitis - correct answerCellulitis
A 53-year-old man presents to the clinic to establish care. He recently had labs
performed at a local health fair and was told to seek care for an elevated hemoglobin
level. He has been experiencing intense itching after showering and reports that his
cheeks have been redder than usual. Physical exam reveals a ruddy appearance of the
cheeks and mild excoriations on the arms and legs. Laboratory results reveal
hemoglobin of 19 g/dL, hematocrit of 58%, and a platelet count of 662,000/mcL. Which
of the following is the most likely diagnosis?
A.
Anemia of chronic disease
Incorrect
B.
Myelodysplastic syndrome
Incorrect
C.
Polycythemia vera
Correct
D.
Thrombocytopenia - correct answerPolycythemia vera
Which of the following laboratory results is consistent with Addison disease?
A.
Decreased adrenocorticotropic hormone and cortisol levels
, Incorrect
B.
Decreased adrenocorticotropic hormone levels and increased cortisol levels
Incorrect
C.
Increased adrenocorticotropic hormone and cortisol levels
Incorrect
D.
Increased adrenocorticotropic hormone levels and decreased cortisol levels - correct
answerIncreased adrenocorticotropic hormone levels and decreased cortisol levels
A 77-year-old man presents to the clinic with a fever and a productive cough for 2 days.
He reports tan sputum. He has a history of diabetes mellitus and chronic kidney
disease. His temperature is 100°F, and his oxygen saturation is 93% on room air. On
physical exam, the nurse practitioner auscultates crackles in the left lower lobe. Which
of the following is the best treatment regimen for this patient?
A.
Amoxicillin-clavulanate (Augmentin) 875-125 mg orally twice daily for 5 days
Incorrect
B.
Azithromycin (Zithromax) 500 mg orally on day one and then 250 mg orally once daily
for 4 days
Incorrect
C.
Doxycycline (Vibramycin) 100 mg orally twice daily for 5 days
Incorrect
D.
Levofloxacin (Levaquin) 750 mg orally once daily for 5 days - correct
answerLevofloxacin (Levaquin) 750 mg orally once daily for 5 days
A 17-year-old boy presents with lesions on his feet accompanied by intense pruritus and
pain. They have been present for 2 weeks, and he reports no history of allergies or
trauma. On physical examination, his vital signs are within normal limits, and the skin
examination is notable for erythematous erosions and scales between the toes of both
feet. There are also some interdigital fissures seen. Which of the following is the most
likely diagnosis?
A.
Candida infection
Incorrect
B.
Erythrasma
Incorrect
C.
Palmoplantar psoriasis
Incorrect
D.
