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Blood Transfusion NCLEX Questions with Correct Answers 2025 | Study Guide & Practice

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Prepare for the NCLEX with our detailed Blood Transfusion study guide. Includes practice questions, correct answers, signs of transfusion reactions, nursing interventions, compatibility rules, and patient safety protocols for 2025.

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Uploaded on
December 14, 2025
Number of pages
20
Written in
2025/2026
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Exam (elaborations)
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Blood Transfusion NCLEX with correct
answers 2025

Thevnursevhasvobtainedvavunitvofvbloodvfromvthevbloodvbankvandvhasvcheckedvthevbloodvbagvprope
rlyvwithvanothervnurse.vJustvbeforevthevbeginningvtransfusion,vthevnursevassessesvwhichvofvthevfoll
owingvitems?



A.vVitalvsignsv

B.vSkinvColorv

C.vUrinevouputv

D.vLatestvhematocritvlevel.v-vcorrect-answersv-CorrectvAnswervAv

Changevinvvitalvsignsvduringvthevtransfusionvfromvthevbaselinevmayvindicatevthatvavtransfusionvrea
v


ctionvisvoccuring.vThisvisvwhyvnursevassessesvvitalvsignsvbeforevthevprocedurevandvagainvafterv15vmi
ntues.vThevothervoptionsvdovnotvidentifyvassessmentvthatvarevrequiredvjustvbeforevbeginningvavtra
nsfusion.



Thevphysicianvordersv2vunitsvofvpackedvRBCsvtovbevadministeredvtovthevclient.vAtv0600vthevnightvshi
ftvnursevinitiatesvthevfirstvunit'svtransfusionvbeforevgoingvoffvshift.vAtv1000vthevdayvshiftvnursevnote
svthevIVvlinevhasvclottedvoffvandvthevtransfusionvhasvnotvbeenvcompleted.vThevnursingvassessmentvr
evealedvthevtransfusionvwasvonlyvapproximatelyv75%vcomplete.vWhichvofvthevactionsvbyvthevnurse
visvmostvappropriate?

,A.vAdvisevthevbloodvbankvaboutvthevdelayvforvthevnextvunit.

B.vRestartvanothervperipheralvlinevwithv0.9%vNSvandvrestart

thevbloodvtransfusionvwithvthevremainingvbloodvunit.

C.vDiscontinuevthevtransfusion.

D.vDocumentvthevamountvinfusedvthusvfarvandvcontinuevthevtransfusion.v-vcorrect-answersv-
AnswervC

Rationale:vAvunitvofvbloodvshouldvbevadministered

v withinvav4vhourvperiodvofvtime.vThevnursevshouldvdiscontinuevthev

transfusion,vdocumentvthevfindingsvandvnotifyvthevbloodvbank.vThev

agencyvpolicyvwillvneedvtovbevfollowedvconcerningvthevdocumentationv

processvandvnotificationvofvappropriatevpersonnel.vContinuingvthev

transfusionvwithvthev"open"vunitvwillvexposevthevclientvtovanvincreasev

riskvofvinjury.



ThevclientvwithvO+vbloodvisvinvneedvofvanvemergencyvtransfusionvbutvthevlabvdoesvnotvhavevanyvO+v
bloodvavailable.vWhichvpotentialvunitvofvbloodvcouldvbevgivenvtovthevclient?



1.v0-vunit

2.vA+vunit

3.vB+vunit

4.vAnyvRh+vunitv-vcorrect-answersv-Correctvanswer:vAnswerv1.



1.vO-
vnegativevbloodvisvconsideredvthevuniversalvdonorvbecausevitvdoesvnotvcontainvthevantigensvA,vB,vo


rvRh.v(AB+

isvconsideredvthevuniversalvrecipientvbecausevavpersonvwithvthisvbloodvtypevhasvallvthevanti-
gensvonvthevblood).

, 2.A+vbloodvcontainsvthevantigenvAvthatvthevclientvwillvreactvto,vcausingvthevdevelopmentvofvantibo
dies.vThevunitvbeingvRh+

isvcompatiblevwithvthevclient.

3.B+vbloodvcontainsvthevantigenvBvthatvthevclientvwillvreactvto,vcausingvthevdevelopmentvofvanti-
bodies.vThevunitvbeingvRh+

isvcompatiblevwithvthevclient.

4.ThisvclientvdoesvnotvhavevantigensvAvorvBvonvthevblood.vAdministrationvofvthesevtypesvwouldvcau
sevanvantigen/antibodyvreactionvwithinvthevclient'svbody,vresultingvinvavmassivevhemolysisvofvthevcl
ient'svbloodvandvdeath."



AboutvtenvminutesvaftervthevnursevbeginsvanvinfusionvofvpackedvRBCs,vthevpatientvcomplainsvofvchi
lls,vchestvandvbackvpain,vandvnausea.vHisvfacevisvflushed,vandvhe'svanxious.vWhichvisvthevpriorityvnu
rsingvaction?v



1.vAdministeringvantihistaminesvSTATvforvanvallergicvreaction.v

2.vNotifyingvthevphysicianvofvavpossiblevtransfusionvreaction.v

3.vObtainingvavurinevandvserumvspecimenvtovsendvtovthevlabvimmediately.v

4.vStoppingvhtevtransfusionvandvmaintainingvavpatentvIVvcatheter.v-vcorrect-answersv-
Thevcorrectvanswervisv4.vThevpatientvisvexperiencingvavtransfusionvreaction.vThevimmediatevnursin
gvactionvisvtovstopvthevtransfusionvandvmaintainvavpatentvIVvline.vThevothervoptionsvmayvbevindicat
edvbutvaren'tvthevpriorityvinvthisvcase.



Thevnursevisvadministeringvpackedvredvbloodvcellsv(PRBCs)vtovavclient.vThevnursevshouldvfirst:v



1.vDiscontinuevthevI.V.vcathetervifvavbloodvtransfusionvreactionvoccurs.

2.vAdministervthevPRBCsvthroughvavpercutaneouslyvinsertedvcentralv

cathetervlinevwithvav20-gaugevneedle.v

3.vFlushvPRBCsvwithv5%vdextrosevandv0.45%vnormalvsalinevsolution.v

4.vStayvwithvthevclientvduringvthevfirstv15vminutesvofvinfusion.v-vcorrect-answersv-Correct:v4
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