Walden 6630 Psychopharmacology
Exam Study Guide
1. First generation Antipsychotics (Typical) bind more tightly to D2 receptors and are
not "kicked off" when excess Dopamine is around. This characteristic makes them
more likely to cause:
A) Serotonin syndrome
B) Extrapyramidal Symptoms
C) Hypertensive crisis
D) Agranulocytosis
Answer: B) Extrapyramidal Symptoms
2. A spasm of the extraocular muscles causing an upward and outward position of the
eyes (possible extrapyramidal symptom associated with typical antipsychotics can
occur within hours to days of treatment):
A) Akathisia
B) Tardive Dyskinesia
C) Oculogyric Crisis
D) Pseudoparkinsonism
Answer: C) Oculogyric Crisis
3. Acute extrapyramidal symptoms include:
A) Dystonia, Akathisia, and Pseudoparkinsonism
B) Only Tardive Dyskinesia
C) Serotonin syndrome
D) Neuroleptic Malignant Syndrome only
Answer: A) Dystonia, Akathisia, and Pseudoparkinsonism
4. Advanced Neuroleptic Malignant Syndrome can cause:
A) Liver failure
B) Rhabdomyolysis
C) Renal stones
D) Pancreatitis
Answer: B) Rhabdomyolysis
5. Adverse effects of MAOIs include:
A) Agranulocytosis
B) Serotonin syndrome and hypertensive crisis
,C) QT prolongation only
D) Tardive dyskinesia
Answer: B) Serotonin syndrome and hypertensive crisis
6. All SSRIs but paroxetine are pregnancy category:
A) A
B) B
C) C
D) D
Answer: C) C
7. Another pathway of the CNS that is rich in Dopamine receptors and is responsible
for eating behavior:
A) Nigrostriatal
B) Mesolimbic
C) Medullary Periventricular
D) Mesocortical
Answer: C) Medullary Periventricular
8. Another region of the CNS that is rich in Dopamine receptors and is responsible for
initiating the vomiting reflex:
A) Medulla oblongata
B) Chemoreceptor trigger zone
C) Cerebellum
D) Hippocampus
Answer: B) Chemoreceptor trigger zone
9. As a Serotonin Antagonist, this Atypical Antidepressant blocks 5-HT2A and
5-HT3A receptors to increase the amount of Serotonin available to bind to 5-HT1A
receptors:
A) Bupropion
B) Trazodone
C) Mirtazapine
D) Venlafaxine
Answer: C) Mirtazapine
10. As Serotonin Antagonists, these two Atypical Antidepressants block 5-HT2A
receptors so that more Serotonin is available to bind to 5-HT1A receptors:
A) Vilazodone and vortioxetine
B) Trazodone and nefazodone
, C) Duloxetine and venlafaxine
D) Fluoxetine and sertraline
Answer: B) Trazodone and nefazodone
11. Because of its effect on blocking dopamine receptors in the tuberoinfundibular
pathway, this Atypical Antipsychotic is the most likely to cause Hyperprolactinemia:
A) Clozapine
B) Quetiapine
C) Risperidone
D) Aripiprazole
Answer: C) Risperidone
12. Because they also block D2 receptors in the tuberoinfundibular pathway, Atypical
Antipsychotics can cause:
A) Seizures
B) Hyperprolactinemia
C) Hypertension
D) Bradycardia
Answer: B) Hyperprolactinemia
13. Before starting another antidepressant, MAOIs should be stopped for at least:
A) One week
B) Two weeks
C) Three weeks
D) Four weeks
Answer: B) Two weeks
14. Cardiac side effects of Atypical Antipsychotics (especially ziprasidone) include:
A) Bradycardia
B) Heart block
C) Prolongation of the QT interval
D) Bundle branch block
Answer: C) Prolongation of the QT interval
15. Cardiac side effects of Typical Antipsychotics include:
A) ST elevation
B) Prolongation of the QT interval
C) T wave inversion
D) Atrial fibrillation
Answer: B) Prolongation of the QT interval
Exam Study Guide
1. First generation Antipsychotics (Typical) bind more tightly to D2 receptors and are
not "kicked off" when excess Dopamine is around. This characteristic makes them
more likely to cause:
A) Serotonin syndrome
B) Extrapyramidal Symptoms
C) Hypertensive crisis
D) Agranulocytosis
Answer: B) Extrapyramidal Symptoms
2. A spasm of the extraocular muscles causing an upward and outward position of the
eyes (possible extrapyramidal symptom associated with typical antipsychotics can
occur within hours to days of treatment):
A) Akathisia
B) Tardive Dyskinesia
C) Oculogyric Crisis
D) Pseudoparkinsonism
Answer: C) Oculogyric Crisis
3. Acute extrapyramidal symptoms include:
A) Dystonia, Akathisia, and Pseudoparkinsonism
B) Only Tardive Dyskinesia
C) Serotonin syndrome
D) Neuroleptic Malignant Syndrome only
Answer: A) Dystonia, Akathisia, and Pseudoparkinsonism
4. Advanced Neuroleptic Malignant Syndrome can cause:
A) Liver failure
B) Rhabdomyolysis
C) Renal stones
D) Pancreatitis
Answer: B) Rhabdomyolysis
5. Adverse effects of MAOIs include:
A) Agranulocytosis
B) Serotonin syndrome and hypertensive crisis
,C) QT prolongation only
D) Tardive dyskinesia
Answer: B) Serotonin syndrome and hypertensive crisis
6. All SSRIs but paroxetine are pregnancy category:
A) A
B) B
C) C
D) D
Answer: C) C
7. Another pathway of the CNS that is rich in Dopamine receptors and is responsible
for eating behavior:
A) Nigrostriatal
B) Mesolimbic
C) Medullary Periventricular
D) Mesocortical
Answer: C) Medullary Periventricular
8. Another region of the CNS that is rich in Dopamine receptors and is responsible for
initiating the vomiting reflex:
A) Medulla oblongata
B) Chemoreceptor trigger zone
C) Cerebellum
D) Hippocampus
Answer: B) Chemoreceptor trigger zone
9. As a Serotonin Antagonist, this Atypical Antidepressant blocks 5-HT2A and
5-HT3A receptors to increase the amount of Serotonin available to bind to 5-HT1A
receptors:
A) Bupropion
B) Trazodone
C) Mirtazapine
D) Venlafaxine
Answer: C) Mirtazapine
10. As Serotonin Antagonists, these two Atypical Antidepressants block 5-HT2A
receptors so that more Serotonin is available to bind to 5-HT1A receptors:
A) Vilazodone and vortioxetine
B) Trazodone and nefazodone
, C) Duloxetine and venlafaxine
D) Fluoxetine and sertraline
Answer: B) Trazodone and nefazodone
11. Because of its effect on blocking dopamine receptors in the tuberoinfundibular
pathway, this Atypical Antipsychotic is the most likely to cause Hyperprolactinemia:
A) Clozapine
B) Quetiapine
C) Risperidone
D) Aripiprazole
Answer: C) Risperidone
12. Because they also block D2 receptors in the tuberoinfundibular pathway, Atypical
Antipsychotics can cause:
A) Seizures
B) Hyperprolactinemia
C) Hypertension
D) Bradycardia
Answer: B) Hyperprolactinemia
13. Before starting another antidepressant, MAOIs should be stopped for at least:
A) One week
B) Two weeks
C) Three weeks
D) Four weeks
Answer: B) Two weeks
14. Cardiac side effects of Atypical Antipsychotics (especially ziprasidone) include:
A) Bradycardia
B) Heart block
C) Prolongation of the QT interval
D) Bundle branch block
Answer: C) Prolongation of the QT interval
15. Cardiac side effects of Typical Antipsychotics include:
A) ST elevation
B) Prolongation of the QT interval
C) T wave inversion
D) Atrial fibrillation
Answer: B) Prolongation of the QT interval
