GNUR 294 EXAM III Pharmacotherapy of Dyslipidemia | rated 100%

GNUR 294 EXAM III Pharmacotherapy of Dyslipidemia • Lipids are the culprit that help increase the levels of plaque inside the walls • Three types of lipids that the drugs are going to effect • LDL- “bad”, forms the plaque in the vessel walls • HDL- remove LDL from the bloodstream to be metabolized by the liver • Want LDL levels to be low, HDL to be high, the higher the better because the lower LDL • VLDLs- triglycerides, they are closely tied to carbohydrate metabolism • One or more of these combinations of these drugs • TLCs- therapeutic lifestyle changes • Foods with LDLs- saturated fats (dairy products, meat products, animal fats) • If patients have risk factors for heart disease, need to make sure lipid levels are in normal range • Nicotine is thought to increase the inflammation • Since the liver metabolizes the cholesterol, the gene that controls metabolism is defective, that patient will have high LDLs, won’t change no matter their diet/life style changes • HMG-CoA reductaste- stop the liver from it’s normal metabolism, need cholesterol in our diets. Negative feedback- if cholesterol levels drop, the liver will produce more, if it rises lets all the enzymes take care of it. Inhibits enzymes. In doing that the liver it makes more receptors to reduce the LDL • Rarely will see just one of these given