KUBY IMMUNOLOGY- CHAPTER 2
EXAM QUESTIONS AND ANSWERS
These are specialized sites in the gut and other mucosal tissues that coordinate the
encounter of antigen with antigen-specific lymphocytes and their development into
effector and memory cells. ex. spleen, lymph nodes - Correct Answers -secondary
lymphoid organs
These organs (thymus and bone marrow) regulate the development of immune cells
from immature precursors. - Correct Answers -primary lymphoid organs
It gives rise to all functionally specialized, mature blood cells (red blood cells,
granulocytes, macrophages, dendritic cells, and lymphocytes). - Correct Answers -
hematopoietic stem cell (HSC)
The process by which HSCs differentiate into mature blood cells is called
_____________________ - Correct Answers -hematopoiesis
It is where the HSCs reside and give rise to all cell types. - Correct Answers -bone
marrow
It is where T cells complete their maturation. - Correct Answers -thymus
The two important features of stem cells - Correct Answers -ability to regenerate or
"self-renew"
ability to differentiate into all diverse cell types (pluripotent)
These are HSC daughter cells that lose their self-renewal abilities after differentiation. -
Correct Answers -progenitor cells
True or False. As an organism ages, the number of HSCs increases. - Correct Answers
-False
The _____________________ gives rise to all red blood cells (the erythroid lineage),
granulocytes, monocytes, and macrophages (the myeloid lineage), while the
_______________ which gives rise to B lymphocytes, T lymphocytes, and NK cells. -
Correct Answers -common myeloid-erythroid progenitor (CMP)
common lymphoid progenitor (CLP)
Cells that originate from the common myeloid-erythroid progenitor (CMP) - Correct
Answers -red blood cells
, granulocytes
monocytes
macrophages
Cells that originate from the common lymphoid progenitor (CLP) - Correct Answers -B
lymphocytes
T lymphocytes
NK cells
They are the first cells to respond to infection. - Correct Answers -Myeloid cells
(monocytes, granulocytes, macrophages)
NK cells
It is the cell that arises from both myeloid and lymphoid lineages. - Correct Answers -
dendritic cells
This transcription factor is required for the development of all hematopoietic lineages; in
its absence animals die during embryogenesis. - Correct Answers -GATA-2
This transcriptional regulator is required for the self-renewal capacity of HSCs, and in its
absence animals die within 2 months of birth because of the failure to repopulate their
red and white blood cells. - Correct Answers -Bmi-1
This family of transcriptional regulator is required for lymphoid but not myeloid
development; animals survive in its absence but cannot mount a full immune response.
- Correct Answers -Ikaros
It is one of four Notch family members that regulates the choice between T and B
lymphocyte lineages. - Correct Answers -Notch1
Which among the basophils and eosinophils are acidic? - Correct Answers -eosinophils
These are white blood cells that are considered part of the innate immune system,
which has round multi-lobed nuclei. It contains a compartment filled with a variety of
proteins with distinct functions Some damage pathogens directly; some regulate
trafficking and activity of other white blood cells, including lymphocytes; and some
contribute to the remodeling of tissues at the site of infection. - Correct Answers -
granulocytes
It contains the majority of circulating leukocytes and the main component of pus. After
differentiation in the bone marrow, it is released to the blood and circulates for 7 to 10
hours before migrating to tissues. These cells significantly increase due to inflammatory
chemokines during an infection. PHAGOCYTIC; GRANULOCYTE - Correct Answers -
Neutrophils
EXAM QUESTIONS AND ANSWERS
These are specialized sites in the gut and other mucosal tissues that coordinate the
encounter of antigen with antigen-specific lymphocytes and their development into
effector and memory cells. ex. spleen, lymph nodes - Correct Answers -secondary
lymphoid organs
These organs (thymus and bone marrow) regulate the development of immune cells
from immature precursors. - Correct Answers -primary lymphoid organs
It gives rise to all functionally specialized, mature blood cells (red blood cells,
granulocytes, macrophages, dendritic cells, and lymphocytes). - Correct Answers -
hematopoietic stem cell (HSC)
The process by which HSCs differentiate into mature blood cells is called
_____________________ - Correct Answers -hematopoiesis
It is where the HSCs reside and give rise to all cell types. - Correct Answers -bone
marrow
It is where T cells complete their maturation. - Correct Answers -thymus
The two important features of stem cells - Correct Answers -ability to regenerate or
"self-renew"
ability to differentiate into all diverse cell types (pluripotent)
These are HSC daughter cells that lose their self-renewal abilities after differentiation. -
Correct Answers -progenitor cells
True or False. As an organism ages, the number of HSCs increases. - Correct Answers
-False
The _____________________ gives rise to all red blood cells (the erythroid lineage),
granulocytes, monocytes, and macrophages (the myeloid lineage), while the
_______________ which gives rise to B lymphocytes, T lymphocytes, and NK cells. -
Correct Answers -common myeloid-erythroid progenitor (CMP)
common lymphoid progenitor (CLP)
Cells that originate from the common myeloid-erythroid progenitor (CMP) - Correct
Answers -red blood cells
, granulocytes
monocytes
macrophages
Cells that originate from the common lymphoid progenitor (CLP) - Correct Answers -B
lymphocytes
T lymphocytes
NK cells
They are the first cells to respond to infection. - Correct Answers -Myeloid cells
(monocytes, granulocytes, macrophages)
NK cells
It is the cell that arises from both myeloid and lymphoid lineages. - Correct Answers -
dendritic cells
This transcription factor is required for the development of all hematopoietic lineages; in
its absence animals die during embryogenesis. - Correct Answers -GATA-2
This transcriptional regulator is required for the self-renewal capacity of HSCs, and in its
absence animals die within 2 months of birth because of the failure to repopulate their
red and white blood cells. - Correct Answers -Bmi-1
This family of transcriptional regulator is required for lymphoid but not myeloid
development; animals survive in its absence but cannot mount a full immune response.
- Correct Answers -Ikaros
It is one of four Notch family members that regulates the choice between T and B
lymphocyte lineages. - Correct Answers -Notch1
Which among the basophils and eosinophils are acidic? - Correct Answers -eosinophils
These are white blood cells that are considered part of the innate immune system,
which has round multi-lobed nuclei. It contains a compartment filled with a variety of
proteins with distinct functions Some damage pathogens directly; some regulate
trafficking and activity of other white blood cells, including lymphocytes; and some
contribute to the remodeling of tissues at the site of infection. - Correct Answers -
granulocytes
It contains the majority of circulating leukocytes and the main component of pus. After
differentiation in the bone marrow, it is released to the blood and circulates for 7 to 10
hours before migrating to tissues. These cells significantly increase due to inflammatory
chemokines during an infection. PHAGOCYTIC; GRANULOCYTE - Correct Answers -
Neutrophils
