IMMUNOLOGY FINAL EXAM (KUBY
7TH EDITION CHPT 15-19)
Four Types of Hypersensitivity Reactions - Correct Answers -Type I, Type II, Type III, &
Type IV
Type I Hypersensitivity - Correct Answers -Allergy & Atopy (IgE)
Type II Hypersensitivity - Correct Answers -Ab-mediated hypersensitivity (IgG & IgM)
Type III Hypersensitivity - Correct Answers -Immune complex-mediated hypersensitivity
(Immune-complexes)
Type IV - Correct Answers -Delayed Type Hypersensitivity (DTH) (T-Cells)
3 Mechanisms of Type II Hypersensitivity - Correct Answers -- Ab can activate
complement --- Mac
-Ab can mediate ADCC
- Ab can serve as Opsonin
Transfusion Reactions, Hemolytic diseases of the newborn, & Hemolytic Anemia (drug
induced) is what kind of Hypersensitivity Reaction? - Correct Answers -Type II
Hypersensitivity Reaction
Concerning Hemolytic Disease of the Newborn, why is the first pregnancy not severely
affected? - Correct Answers -- Primary Response: IgM
- Secondary Response: IgG
What can induce Hemolytic Anemia? - Correct Answers -Drugs: Pennicillin,
Streptomycin, Ibuprofen, Naproxen.
- Drug gets absorbed into membrane proteins. Act as new Ag.
After an organ transplant, which combination showed an overall higher survival
percentage? [Cyclosporin-A + Corticosteroids] or [Azathiprine + Corticosteroids]? -
Correct Answers -Cyclosporin-A + Corticosteroids
Antigen-Specific immunosuppressive therapy includes using monoclonal Abs or soluble
CTLA-4 fusion proteins. (true/false) - Correct Answers -True
, In a transplant patient, presence & activities of Treg allowed for complete removal of
anti-rejection drugs. (true/false) - Correct Answers -True
What triggers a Type III Hypersensitivity Reaction? - Correct Answers -- Caused by
large amounts of immune complexes that arn't removed by normal mechanisms.
- Immune complexes = Ag+Ig (soluble)
Where can Type III Hypersensitivity Reactions occur? - Correct Answers -Depends on
where the Immune Complexes are Deposited.
- Near site of entry (localized)
- If it enters the blood (synovial membrane of joints, glomerular basement membrane,
blood vessel walls)
4 step mechanism of Type III Hypersensitivity Reactions - Correct Answers -1. Immune
complex activates complement
2. generate anaphylatoxins(C3a, C4a, C5a)
3. Recruits Neutrophils & granule release)
4. Anaphyltoxins cause mast cell degranulation
Arthus Reaction - Correct Answers -Localized Type III Hypersensitivity Reaction.
Occurs when Ag is applied subcutanously to an individual w/ high corresponding Ab.
Serum Sickness - Correct Answers -Late 19th Century- bacterial infections were treated
by injecting horse serum from horses immunized to a particular bacterial infection.
Farmers Lungs - Correct Answers -Type III Hypersensitivity Reaction that occurs when
moldy hay is inhaled.
Diseases resulting from Type III Hypersensitivity Reactions - Correct Answers --
Autoimmune diseases
- systemic lupus erythematosus (SLE)
- Rheumatoid Artheritis
- Multiple Sclerosis
- Hepatitis
4 step mechanism of a Type IV Hypersensitivity Reaction - Correct Answers -1. Th Cell
encounters Ag
2. Th Cell secrete cytokines that induced localized inflammatory reaction
3. Delayed-Type Hypersensitivity Reaction
4. Cytokines cause large influx of Mac's which cause tissue damage
Hallmarks of Type IV Hypersensitivity Reaction (DTH) - Correct Answers -- Delayed
time for reaction to develope (1-3 days)
- Purely cell-mediated rather than Ab-mediated
- Recruitment of Mac's (as opposed to neutrophils in type III Hypersensitivity reaction)
7TH EDITION CHPT 15-19)
Four Types of Hypersensitivity Reactions - Correct Answers -Type I, Type II, Type III, &
Type IV
Type I Hypersensitivity - Correct Answers -Allergy & Atopy (IgE)
Type II Hypersensitivity - Correct Answers -Ab-mediated hypersensitivity (IgG & IgM)
Type III Hypersensitivity - Correct Answers -Immune complex-mediated hypersensitivity
(Immune-complexes)
Type IV - Correct Answers -Delayed Type Hypersensitivity (DTH) (T-Cells)
3 Mechanisms of Type II Hypersensitivity - Correct Answers -- Ab can activate
complement --- Mac
-Ab can mediate ADCC
- Ab can serve as Opsonin
Transfusion Reactions, Hemolytic diseases of the newborn, & Hemolytic Anemia (drug
induced) is what kind of Hypersensitivity Reaction? - Correct Answers -Type II
Hypersensitivity Reaction
Concerning Hemolytic Disease of the Newborn, why is the first pregnancy not severely
affected? - Correct Answers -- Primary Response: IgM
- Secondary Response: IgG
What can induce Hemolytic Anemia? - Correct Answers -Drugs: Pennicillin,
Streptomycin, Ibuprofen, Naproxen.
- Drug gets absorbed into membrane proteins. Act as new Ag.
After an organ transplant, which combination showed an overall higher survival
percentage? [Cyclosporin-A + Corticosteroids] or [Azathiprine + Corticosteroids]? -
Correct Answers -Cyclosporin-A + Corticosteroids
Antigen-Specific immunosuppressive therapy includes using monoclonal Abs or soluble
CTLA-4 fusion proteins. (true/false) - Correct Answers -True
, In a transplant patient, presence & activities of Treg allowed for complete removal of
anti-rejection drugs. (true/false) - Correct Answers -True
What triggers a Type III Hypersensitivity Reaction? - Correct Answers -- Caused by
large amounts of immune complexes that arn't removed by normal mechanisms.
- Immune complexes = Ag+Ig (soluble)
Where can Type III Hypersensitivity Reactions occur? - Correct Answers -Depends on
where the Immune Complexes are Deposited.
- Near site of entry (localized)
- If it enters the blood (synovial membrane of joints, glomerular basement membrane,
blood vessel walls)
4 step mechanism of Type III Hypersensitivity Reactions - Correct Answers -1. Immune
complex activates complement
2. generate anaphylatoxins(C3a, C4a, C5a)
3. Recruits Neutrophils & granule release)
4. Anaphyltoxins cause mast cell degranulation
Arthus Reaction - Correct Answers -Localized Type III Hypersensitivity Reaction.
Occurs when Ag is applied subcutanously to an individual w/ high corresponding Ab.
Serum Sickness - Correct Answers -Late 19th Century- bacterial infections were treated
by injecting horse serum from horses immunized to a particular bacterial infection.
Farmers Lungs - Correct Answers -Type III Hypersensitivity Reaction that occurs when
moldy hay is inhaled.
Diseases resulting from Type III Hypersensitivity Reactions - Correct Answers --
Autoimmune diseases
- systemic lupus erythematosus (SLE)
- Rheumatoid Artheritis
- Multiple Sclerosis
- Hepatitis
4 step mechanism of a Type IV Hypersensitivity Reaction - Correct Answers -1. Th Cell
encounters Ag
2. Th Cell secrete cytokines that induced localized inflammatory reaction
3. Delayed-Type Hypersensitivity Reaction
4. Cytokines cause large influx of Mac's which cause tissue damage
Hallmarks of Type IV Hypersensitivity Reaction (DTH) - Correct Answers -- Delayed
time for reaction to develope (1-3 days)
- Purely cell-mediated rather than Ab-mediated
- Recruitment of Mac's (as opposed to neutrophils in type III Hypersensitivity reaction)
