WILKES NSG 552 PSYCHOPHARMACOLOGY
EXAM 1 2026 FINAL PAPER QUESTIONS WITH
FULL ANSWERS AND SOLUTIONS GRADED A+
◉ This class is associated with fewer neurological side effects and
effective for both positive and negative symptoms. Answer: Second-
generation antipsychotics
◉ This class is effective for only positive symptoms and can in fact
worsen negative symptoms due to decreased DA in the mesocortical
pathway. Answer: First generation antipsychotics
◉ Associated with metabolic side effects. Answer: Second-
generation antipsychotics
◉ What are the metabolic side effects associated Atypical
antipsychotics:. Answer: Hyperglycemia, glucose disregulation, lipid
disturbance. Leading to HTN/DMII/metabolic d/o
◉ Includes medications such as Haloperidol, chlorpromazine,
fluphenazine, perphenzine:. Answer: FGA
◉ Medications for acute agitation or psychosis:. Answer:
,◉ Includes medications such as Olanzapine, Quetiapine,
Risperidone, Clozapine, etc:. Answer: SGA
◉ FGA reduce dopamine transmission by blocking ___________
receptors:. Answer: D2
◉ SGA block both _____________ and _________________ receptors:.
Answer: D2 and Serotonin (usually with 5-HT2A)
◉ High incidence of QTC prolongation, Tardive dyskinesia,
Neuroleptic Malignant Syndrome (NMS), orthostatic hypotension:.
Answer: Typical
◉ H1 blockade leads to symptoms of ____________ and ____________:.
Answer: sedation and weight gain
◉ Involuntary teeth grinding associated with antipsychotics:.
Answer: Bruxism
◉ Safest and best tolerated anticonvulsant for patients taking
clozapine who experience dose-related seizures:. Answer: valproate
, ◉ Less incidence of antiadrenegic, anticholinergic and antihistamine
side effects but greater EPS:. Answer: Higher potency antipsychotics
◉ Greater incidence of antiadrenergic anticholinergic and
antihistamine side effects but less EPS:. Answer: Lower potency
antipsycotics
◉ Characterized by bradykinesia, mask-like face, cogwheel rigidity,
pill rolling, tremor:. Answer: Parkinsonian side effects
◉ Characterized by torticollis, oculogyric crisis, and can be life
threatening if it affects the airway:. Answer: Acute dystonia
◉ Characterized by an internal and external restlessness, constant
need to pace or walk:. Answer: akithesia
◉ Onset of symptoms for dystonia:. Answer: hours to days after
starting treatment
◉ Onset of symptoms for Parkinsonism/Akathisia:. Answer: days to
weeks after starting antipsychotic treament
◉ Onset of symptoms of Tardive Dyskinesia:. Answer: late onset.
Usually months to years after initiating antipsychotic treatment.
EXAM 1 2026 FINAL PAPER QUESTIONS WITH
FULL ANSWERS AND SOLUTIONS GRADED A+
◉ This class is associated with fewer neurological side effects and
effective for both positive and negative symptoms. Answer: Second-
generation antipsychotics
◉ This class is effective for only positive symptoms and can in fact
worsen negative symptoms due to decreased DA in the mesocortical
pathway. Answer: First generation antipsychotics
◉ Associated with metabolic side effects. Answer: Second-
generation antipsychotics
◉ What are the metabolic side effects associated Atypical
antipsychotics:. Answer: Hyperglycemia, glucose disregulation, lipid
disturbance. Leading to HTN/DMII/metabolic d/o
◉ Includes medications such as Haloperidol, chlorpromazine,
fluphenazine, perphenzine:. Answer: FGA
◉ Medications for acute agitation or psychosis:. Answer:
,◉ Includes medications such as Olanzapine, Quetiapine,
Risperidone, Clozapine, etc:. Answer: SGA
◉ FGA reduce dopamine transmission by blocking ___________
receptors:. Answer: D2
◉ SGA block both _____________ and _________________ receptors:.
Answer: D2 and Serotonin (usually with 5-HT2A)
◉ High incidence of QTC prolongation, Tardive dyskinesia,
Neuroleptic Malignant Syndrome (NMS), orthostatic hypotension:.
Answer: Typical
◉ H1 blockade leads to symptoms of ____________ and ____________:.
Answer: sedation and weight gain
◉ Involuntary teeth grinding associated with antipsychotics:.
Answer: Bruxism
◉ Safest and best tolerated anticonvulsant for patients taking
clozapine who experience dose-related seizures:. Answer: valproate
, ◉ Less incidence of antiadrenegic, anticholinergic and antihistamine
side effects but greater EPS:. Answer: Higher potency antipsychotics
◉ Greater incidence of antiadrenergic anticholinergic and
antihistamine side effects but less EPS:. Answer: Lower potency
antipsycotics
◉ Characterized by bradykinesia, mask-like face, cogwheel rigidity,
pill rolling, tremor:. Answer: Parkinsonian side effects
◉ Characterized by torticollis, oculogyric crisis, and can be life
threatening if it affects the airway:. Answer: Acute dystonia
◉ Characterized by an internal and external restlessness, constant
need to pace or walk:. Answer: akithesia
◉ Onset of symptoms for dystonia:. Answer: hours to days after
starting treatment
◉ Onset of symptoms for Parkinsonism/Akathisia:. Answer: days to
weeks after starting antipsychotic treament
◉ Onset of symptoms of Tardive Dyskinesia:. Answer: late onset.
Usually months to years after initiating antipsychotic treatment.
