Molecular Signal Transduction
.
BY: Abraham D (Msc)
, Outlines
• Introduction to cell signaling
• Key elements in signal transduction
• Type of signaling based on distance
• Steps of signal transduction
• Signaling molecules
• Signal transduction through various receptors
• Promising drug targets
2
, Introduction to cell signaling
• Cells regulate its intracellular and extracellular environment, processes the
information it gathers, and responds accordingly.
• Cell signaling is the ability of a cell to receive, process, and transmit signals
with its environment and with itself.
It is a fundamental property of all cells in every living organism
• Cell signaling is a controlled dynamic process
• Have mechanisms for responding to physical and chemical changes in their
environment.
• This mechanism helps cells to have a communication with other cells
3
, Cont…
• Reception of the signals depends on protein at the cell surface
• Most are receptors
• The binding activates the receptor, which in turn activates one
or more intracellular signaling pathways or systems
Then distribute it to the appropriate intracellular targets
Effector proteins
.
BY: Abraham D (Msc)
, Outlines
• Introduction to cell signaling
• Key elements in signal transduction
• Type of signaling based on distance
• Steps of signal transduction
• Signaling molecules
• Signal transduction through various receptors
• Promising drug targets
2
, Introduction to cell signaling
• Cells regulate its intracellular and extracellular environment, processes the
information it gathers, and responds accordingly.
• Cell signaling is the ability of a cell to receive, process, and transmit signals
with its environment and with itself.
It is a fundamental property of all cells in every living organism
• Cell signaling is a controlled dynamic process
• Have mechanisms for responding to physical and chemical changes in their
environment.
• This mechanism helps cells to have a communication with other cells
3
, Cont…
• Reception of the signals depends on protein at the cell surface
• Most are receptors
• The binding activates the receptor, which in turn activates one
or more intracellular signaling pathways or systems
Then distribute it to the appropriate intracellular targets
Effector proteins
