NSG 533 advanced pharm exam 2 Latest
guide with complete solution/Advanced
Pharmacology Final Exam Questions and
Answers(100% Verified)
Which drug class is most effective in treating erosive lesions:? - ANSWER>>PPIs
Name 4 H2RAs: - ANSWER>>Cimetidine (Tagamet)
Famotidine (Pepcid)
Ranitidine (Zantac)
Nizatidine (Axid)
What is the action of H2RAs? - ANSWER>>Decrease acid secretion by blocking
histamine 2-receptors in gastric parietal cells
Name 4 benefits of H2RAs - ANSWER>>1. Relieve GERD symptoms
2. Can be administered prophylactically
3. More effective at controlling chronic GERD symptoms than ANTACIDS
4. Intermittent & routine dosing possible based on degree of symptom control
needed.
Name 2 drawbacks of H2RAs - ANSWER>>1. Less effective in controlling chronic
GERD symptoms than PPIs
2. Renal elimination may require dose adjustment in kidney dysfunction patients
What are the side effects associated with H2RAs? - ANSWER>>H/A, nausea
(Cimetidine), weak inhibitor, common drug interactions, gynecomastia, & Vit B-12
deficiency which affects patients' tolerance
Name the benefits of Antacids - ANSWER>>1. Useful for intermittent treatment of
GERD symptoms
2. Immediate symptom relief
, 3. Usually well-tolerated
What are the drawbacks of Antacids? - ANSWER>>1. Requires frequent dosing
2. Aluminum or Magnesium containing antacids may result in electrolyte
imbalances esp. in pts. w/renal impairment
3. May interfere w/absorption of fluoroquinolones, tetracyclines, iron products, &
thyroid hormones
(doses should be several hours apart)
What are the side effects of Antacids? - ANSWER>>May cause
Constipation or Diarrhea depending on the formulation used
What is the Pharmacological Therapy Effectiveness of Antacids? -
ANSWER>>Antacids briefly neutralize gastric acid but lacks acid-suppressive
properties & are inferior to H2RAs
What is the Pharmacological Therapy Effectiveness of H2RAs? -
ANSWER>>Histamine-2 Receptor Antagonists decrease acid secretion to a lesser
extent than PPIs (& are therefore inferior to PPIs)
What is the Pharmacological Therapy Effectiveness of PPIs? - ANSWER>>Proton
Pump Inhibitors block the rate-limiting step in acid secretion from gastric parietal
cells & block all pathways for gastric acid secretion & therefore are better than
H2RAs
What is the treatment goal of pharmacological therapy in GERD? -
ANSWER>>Increase the pH of gastric content by; 1) Direct gastric acid
neutralization 2) Reduce acid production through inhibiting the stimulation of
pathways to decrease GERD symptoms and prevent tissue damage
Which Bariatric Surgery is effective in reducing GERD symptoms in obese
patients? - ANSWER>>Roux-en-Y gastric bypass
guide with complete solution/Advanced
Pharmacology Final Exam Questions and
Answers(100% Verified)
Which drug class is most effective in treating erosive lesions:? - ANSWER>>PPIs
Name 4 H2RAs: - ANSWER>>Cimetidine (Tagamet)
Famotidine (Pepcid)
Ranitidine (Zantac)
Nizatidine (Axid)
What is the action of H2RAs? - ANSWER>>Decrease acid secretion by blocking
histamine 2-receptors in gastric parietal cells
Name 4 benefits of H2RAs - ANSWER>>1. Relieve GERD symptoms
2. Can be administered prophylactically
3. More effective at controlling chronic GERD symptoms than ANTACIDS
4. Intermittent & routine dosing possible based on degree of symptom control
needed.
Name 2 drawbacks of H2RAs - ANSWER>>1. Less effective in controlling chronic
GERD symptoms than PPIs
2. Renal elimination may require dose adjustment in kidney dysfunction patients
What are the side effects associated with H2RAs? - ANSWER>>H/A, nausea
(Cimetidine), weak inhibitor, common drug interactions, gynecomastia, & Vit B-12
deficiency which affects patients' tolerance
Name the benefits of Antacids - ANSWER>>1. Useful for intermittent treatment of
GERD symptoms
2. Immediate symptom relief
, 3. Usually well-tolerated
What are the drawbacks of Antacids? - ANSWER>>1. Requires frequent dosing
2. Aluminum or Magnesium containing antacids may result in electrolyte
imbalances esp. in pts. w/renal impairment
3. May interfere w/absorption of fluoroquinolones, tetracyclines, iron products, &
thyroid hormones
(doses should be several hours apart)
What are the side effects of Antacids? - ANSWER>>May cause
Constipation or Diarrhea depending on the formulation used
What is the Pharmacological Therapy Effectiveness of Antacids? -
ANSWER>>Antacids briefly neutralize gastric acid but lacks acid-suppressive
properties & are inferior to H2RAs
What is the Pharmacological Therapy Effectiveness of H2RAs? -
ANSWER>>Histamine-2 Receptor Antagonists decrease acid secretion to a lesser
extent than PPIs (& are therefore inferior to PPIs)
What is the Pharmacological Therapy Effectiveness of PPIs? - ANSWER>>Proton
Pump Inhibitors block the rate-limiting step in acid secretion from gastric parietal
cells & block all pathways for gastric acid secretion & therefore are better than
H2RAs
What is the treatment goal of pharmacological therapy in GERD? -
ANSWER>>Increase the pH of gastric content by; 1) Direct gastric acid
neutralization 2) Reduce acid production through inhibiting the stimulation of
pathways to decrease GERD symptoms and prevent tissue damage
Which Bariatric Surgery is effective in reducing GERD symptoms in obese
patients? - ANSWER>>Roux-en-Y gastric bypass
