Multiple choice questions on Pharmacology of Hematology and Anticoagulation
This topic covers iron and vitamin deficiencies, anemia types, anticoagulant drugs,
antiplatelet therapy, and thrombolytic agents—exactly what your questions focus on.
Choose the best answer and encircle the choice containing it. 1pt each
1. Which of the following co-administered substance can increase absorption of oral iron
preparations?
A. Antacids C. Phosphates
B. Tetracyclines D. Ascorbic acid
2. By which mechanism is the amount of excessive ingested iron can be controlled by gut
wall?
A. Regulating apoferritin to acts as the carrier of iron across the mucosal cell
B. Regulating apoferritin to ferritin interconversion in the mucosal cell
C. Complexing excess iron to form ferritin to be stored in the mucosal cell
D. Regulating the number of transferrin receptors on the mucosal cell
3. The side effect which primarily limits acceptability of oral iron therapy is:
A. Epigastric pain C. Staining of teeth
B. Black stools D. Metallic taste
4. The following is not a valid indication for parenteral iron therapy:
A. Inadequate response to oral iron C. Anaemia during pregnancy
B. Patient noncompliance to oral iron D. Severe anaemia with chronic bleeding
5. Megaloblastic anaemia occurs due to
A. Vitamin B12 but not folic acid deficiency
B. Folic acid but not Vitamin B12 deficiency
C. Either Vitamin B12 or folic acid deficiency
D. Only combined Vitamin B12 + folic acid deficiency
6. Which metabolic reaction requiring vitamin B12 but not folate is
A. Conversion of malonic acid to succinic acid
B. Conversion of homocysteine to methionine
C. Conversion of serine to glycine
D. Conversion of dUMP to dTMP
7. To which special situation does Folinic acid supplement is indicated?
A. Pregnant women receiving anticonvulsant drugs
B. A patient taking high dose of methotrexate
1
, C. A patient having Pernicious anaemia
D. Anaemia associated with chronic renal failure
8. A 9-year-old baby suffering from acute lymphoblastic leukemia was admitted to the
hospital to be treated with high-dose of methotrexate. Which of the following drugs is
best to be co-administered with methotrexate?
A. Folic acid C. Leucovorin
B. Cyanocobalamin D. Ferrous sulfate
9. Low molecular weight heparins differ from conventional heparin in that they ----
A. Significantly prolong the clotting time
B. Readily crosses the placental membrane
C. Selectively inhibit factor Xa than factor IIa
D. Affect factor VIIa, the extrinsic pathway
10. A 80-year-old man presents to the emergency room with acute-onset left-sided weakness
and slurred speech that started since 30 min ago. A diagnosis of his brain with CT scan
confirms an ischemic stroke. The patient is started on alteplase immediately. What is the
mechanism of action of alteplase?
A. Inhibits GP IIb/IIIa C. Activate plasminogen
B. Blocks ADP receptors D. Activates thrombin
11. A 75-year-old man is brought to the emergency department with right calf pain and
swelling. Three weeks ago, he underwent a radical cystectomy for invasive bladder
cancer. Ultrasound reveals a right pelvic vein deep venous thrombosis. The patient was
treated with a bolus of heparin, and a heparin drip was started. One hour later, he started
profound bleeding at the injection site. The heparin therapy was suspended, but the
bleeding continued. Protamine sulphate was administered intravenously that works in
which of the following ways?
A. Activates the coagulation cascade C. Degrades the heparin molecules
B. Activates tissue plasminogen activator D. Complexes with heparin molecules
12. A 70-year-old man, hospitalized for an acute MI, is treated with warfarin. What is the
main mechanism by which warfarin is causing the effects for which it is given?
A. Increase the plasma level of antitherombin III in vivo
B. Inhibition of effect of thrombin and early coagulation steps
C. Inhibition of synthesis of prothrombin and VII, IX, and X
D. Inhibiting synthesis of activated tissue of plasminogen activator
2
This topic covers iron and vitamin deficiencies, anemia types, anticoagulant drugs,
antiplatelet therapy, and thrombolytic agents—exactly what your questions focus on.
Choose the best answer and encircle the choice containing it. 1pt each
1. Which of the following co-administered substance can increase absorption of oral iron
preparations?
A. Antacids C. Phosphates
B. Tetracyclines D. Ascorbic acid
2. By which mechanism is the amount of excessive ingested iron can be controlled by gut
wall?
A. Regulating apoferritin to acts as the carrier of iron across the mucosal cell
B. Regulating apoferritin to ferritin interconversion in the mucosal cell
C. Complexing excess iron to form ferritin to be stored in the mucosal cell
D. Regulating the number of transferrin receptors on the mucosal cell
3. The side effect which primarily limits acceptability of oral iron therapy is:
A. Epigastric pain C. Staining of teeth
B. Black stools D. Metallic taste
4. The following is not a valid indication for parenteral iron therapy:
A. Inadequate response to oral iron C. Anaemia during pregnancy
B. Patient noncompliance to oral iron D. Severe anaemia with chronic bleeding
5. Megaloblastic anaemia occurs due to
A. Vitamin B12 but not folic acid deficiency
B. Folic acid but not Vitamin B12 deficiency
C. Either Vitamin B12 or folic acid deficiency
D. Only combined Vitamin B12 + folic acid deficiency
6. Which metabolic reaction requiring vitamin B12 but not folate is
A. Conversion of malonic acid to succinic acid
B. Conversion of homocysteine to methionine
C. Conversion of serine to glycine
D. Conversion of dUMP to dTMP
7. To which special situation does Folinic acid supplement is indicated?
A. Pregnant women receiving anticonvulsant drugs
B. A patient taking high dose of methotrexate
1
, C. A patient having Pernicious anaemia
D. Anaemia associated with chronic renal failure
8. A 9-year-old baby suffering from acute lymphoblastic leukemia was admitted to the
hospital to be treated with high-dose of methotrexate. Which of the following drugs is
best to be co-administered with methotrexate?
A. Folic acid C. Leucovorin
B. Cyanocobalamin D. Ferrous sulfate
9. Low molecular weight heparins differ from conventional heparin in that they ----
A. Significantly prolong the clotting time
B. Readily crosses the placental membrane
C. Selectively inhibit factor Xa than factor IIa
D. Affect factor VIIa, the extrinsic pathway
10. A 80-year-old man presents to the emergency room with acute-onset left-sided weakness
and slurred speech that started since 30 min ago. A diagnosis of his brain with CT scan
confirms an ischemic stroke. The patient is started on alteplase immediately. What is the
mechanism of action of alteplase?
A. Inhibits GP IIb/IIIa C. Activate plasminogen
B. Blocks ADP receptors D. Activates thrombin
11. A 75-year-old man is brought to the emergency department with right calf pain and
swelling. Three weeks ago, he underwent a radical cystectomy for invasive bladder
cancer. Ultrasound reveals a right pelvic vein deep venous thrombosis. The patient was
treated with a bolus of heparin, and a heparin drip was started. One hour later, he started
profound bleeding at the injection site. The heparin therapy was suspended, but the
bleeding continued. Protamine sulphate was administered intravenously that works in
which of the following ways?
A. Activates the coagulation cascade C. Degrades the heparin molecules
B. Activates tissue plasminogen activator D. Complexes with heparin molecules
12. A 70-year-old man, hospitalized for an acute MI, is treated with warfarin. What is the
main mechanism by which warfarin is causing the effects for which it is given?
A. Increase the plasma level of antitherombin III in vivo
B. Inhibition of effect of thrombin and early coagulation steps
C. Inhibition of synthesis of prothrombin and VII, IX, and X
D. Inhibiting synthesis of activated tissue of plasminogen activator
2
