ERT adverse effects (osteopenia)
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when it's stopped, bone mass rapidly decreases by 12%
Thiazolidinediones (TZDs)
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, Glitazones
MOA:
-decrease insulin resistance, increasing glucose uptake by muscle and fat
-decrease glucose production by liver
SE: hypoglycemia when there is excessive insulin, HF, bladder cancer,
fractures in women, ovulation
vitamin D3 activation
Give this one a try later!
1. sunlight + provitamin D3
2. Cholecalciferol (vit D3)
3. Hepatic enzymes + vit D3 = calcifediol
4. Calcifediol + renal enzymes = Calcitriol
Montelukast
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leukotriene receptor antagonist
maintenance of asthma, EIB (15yo), allergic rhinitis
Type 2 diabetes management
Give this one a try later!
, 1. lifestyle changes PLUS metformin
2. add a second drug (thiazolidinedione, DPP-4 inhibitor, SGLT-2 inhibitor,
or GLP-1 receptor agonist
3. 3 drug combo
4. Insulin & GLP-1 receptor agonist
Type 1 diabetes complications
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Diabetic Ketoacidosis (DKA)
heart disease, renal failure, blindness, neuropathy, amputations, impotence,
stroke
Type 1 diabetes management
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1. diet
2. self-monitoring of blood glucose (SMBG)
3. Physical activity
4. Insulin replacement
methotrexate
Give this one a try later!
, Conventional DMARD
-folate antagonist
>> folate is necessary for DNA synthesis and cellular replication
--benefits are results of immunosuppression secondary to reducing B & T
lymphocyte activity
-effects in 3-6 weeks
AE: hepatic fibrosis, bone marrow suppression, GI ulceration, pneumonitis
TERATOGENIC
Dipeptidyl Peptidase-4 (DPP-4) Inhibitors
Give this one a try later!
Gliptins
- enhance actions of incretin hormones to stimulate glucose-dependent
insulin and suppress glucagon release by inhibiting DPP-4
-DPP-4 is an enzyme that inactivates incretin hormones
AE: hypoglycemia and pancreatitis
T4
Give this one a try later!
thyroxine (tetraiodothyronine)
converts into T3
Give this one a try later!
when it's stopped, bone mass rapidly decreases by 12%
Thiazolidinediones (TZDs)
Give this one a try later!
, Glitazones
MOA:
-decrease insulin resistance, increasing glucose uptake by muscle and fat
-decrease glucose production by liver
SE: hypoglycemia when there is excessive insulin, HF, bladder cancer,
fractures in women, ovulation
vitamin D3 activation
Give this one a try later!
1. sunlight + provitamin D3
2. Cholecalciferol (vit D3)
3. Hepatic enzymes + vit D3 = calcifediol
4. Calcifediol + renal enzymes = Calcitriol
Montelukast
Give this one a try later!
leukotriene receptor antagonist
maintenance of asthma, EIB (15yo), allergic rhinitis
Type 2 diabetes management
Give this one a try later!
, 1. lifestyle changes PLUS metformin
2. add a second drug (thiazolidinedione, DPP-4 inhibitor, SGLT-2 inhibitor,
or GLP-1 receptor agonist
3. 3 drug combo
4. Insulin & GLP-1 receptor agonist
Type 1 diabetes complications
Give this one a try later!
Diabetic Ketoacidosis (DKA)
heart disease, renal failure, blindness, neuropathy, amputations, impotence,
stroke
Type 1 diabetes management
Give this one a try later!
1. diet
2. self-monitoring of blood glucose (SMBG)
3. Physical activity
4. Insulin replacement
methotrexate
Give this one a try later!
, Conventional DMARD
-folate antagonist
>> folate is necessary for DNA synthesis and cellular replication
--benefits are results of immunosuppression secondary to reducing B & T
lymphocyte activity
-effects in 3-6 weeks
AE: hepatic fibrosis, bone marrow suppression, GI ulceration, pneumonitis
TERATOGENIC
Dipeptidyl Peptidase-4 (DPP-4) Inhibitors
Give this one a try later!
Gliptins
- enhance actions of incretin hormones to stimulate glucose-dependent
insulin and suppress glucagon release by inhibiting DPP-4
-DPP-4 is an enzyme that inactivates incretin hormones
AE: hypoglycemia and pancreatitis
T4
Give this one a try later!
thyroxine (tetraiodothyronine)
converts into T3
