Graded A+
Pharmacokinetics - Correct answer-The process by which drugs are absorbed,
distributed within the body, metabolized, and excreted.
ADME - Correct answer-absorption
distribution
metabolism
excretion
Absorption - Correct answer-The route of administration affects the rate and
amount ofabsorption
Routes of Absorption - Correct answer-Oral
Subcutaneous
Intramuscular
Intravenous
inhalation
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,Buccal / Sublingual
Intravenous - Correct answer-within a vein ( no barrier )
Intradermal/Topical - Correct answer-Slow, gradual absorption ( Barrier )
Passive Diffusion - Correct answer-the movement of drugs from an area of higher
concentration to lower concentration
Active Transport - Correct answer-the movement of materials through a cell
membrane using energy
ATP
Lower to higher concentrationPharmacokinetics Absorption (1 of 3)
ATP - Correct answer-energy
Facilitated Diffusion - Correct answer-Movement of specific molecules across cell
membranes through protein channels
No Energy Required
Water-soluble - Correct answer-able to dissolve in water
Crosses through pores in capillaries, but not cell membranes
Ionized
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, Lipid(fat)-soluble - Correct answer--Non-ionized
-Crosses pores, cell membranes, blood-brain barrier
ex: placenta , brain
Physical factors influencing absorption - Correct answer-1. blood flow to
absorbing organ
2. total surface area of absorbing organ
3. contact time at absorption site
4. presence of food
5. sympathetic/parasympathetic activity
6. diarrhea
Distribution - Correct answer-Movement of drug around the body
Blood flow Distribution - Correct answer-Muscles- Slow
Organs - Fast
Capillary Structures - Correct answer-( leaky )
Do not impede diffusion of drugs
Blood Brain Barrier/Placenta - Correct answer-( Tight )
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