Summary Neuroinflammation

Brain specific IL-2 delivery as novel strategy
to prevent pathological neuroinflammation
(Prof. Pasciuto)
1. Neuroinflammation
 Inflammation: host defense response to injury, tissue ischemia, stress,
autoimmune response or infectious agents
o Swelling, redness, heat, pain in various tissues but
 Neuroinflammation: host defense response to injury, tissue ischemia,
stress, autoimmune response or infectious agents etc
o Pain, Neurodegeneration, Cognitive impairment, Motor impairment
etc.
 Important cells
o Glial cells activation
o Cytokine release
o Endothelial cells activation
o Rupture of the BBB
o Proliferation and recruitment of immune cells
o Neuronal damage
 NO CURE at the moment


1.1. Challenges of therapeutic interventions in
neuroinflammation
 Central role of neuro inflammation in brain disorders has only recently
been established.
 In chronic inflammation the inflammation starts before the symptoms >>>
delayed intervention
 In acute inflammation, in most cases prevention is not possible
 Mechanisms?


1.2. Targeting T-cells to prevent neuroinflammation
 Genetic, clinical, and experimental studies shows that both the innate and
the adaptive immune system influence neuroinflammation and
neurodegeneration
 Neuroinflammation, immune cells activation and recruitment
 GWAS identified specific genetic variations (HLA-DR; IL17A; IL10;CD25,
KIR) association to brain disorders
 Biomarker of disease (CSF and blood)
 Clinical trials ongoing to target Adaptive immune system in AD, psychosis
and Autism (e.g. IL2, Tregs
 Effector T cells (CD4 and CD8 T cells)
o Recruit other immune cells
o Cytotoxic
o Pro-inflammatory
 Regulatory T cells (CD4 T cells)
o Immune regulation


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, o Tissue homeostasis and repair
o Anti-inflammatory




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