Primary vs. Secondary Skin Lesions
• Primary – lesions as they originally appear
• Secondary – lesions that have been modified from their original appearance
Herpes Simplex Virus 1 & 2
Pathophysiology
• Herpes virus lives latent in nerve (most often the trigeminal) after initial infection and
reactivates during: o Stress o Sun exposure o Menstruation
Clinical Manifestations
• Burning → redness & vesicles → pustules & ulcers → crust
• Heals in 10-14 days
• Herpes Simplex 1common locations: Lips, face, and mouth
• Herpes Simplex 2 common location: Genital region
Herpes Zoster
Pathophysiology
• Virus lives latent in the spinal ganglia and activates during stress.
Clinical Manifestations
• Pain at areas of vesicles
• Vesicles with a red base (continue to pop up for 3-5 days) that follow the dermatome
(nerve track) → vesicles dry out & crust→ fall off
• Whole process takes 2-3 weeks
• Vesicles are unilateral; usually on face and trunk
• In older adults: pain is worse; duration is longer
Complication
• Permanent blindness can occur if lesions involve the eyes.
• Post-herpetic neuralgia – pain that continues after skin lesions have cleared o Can
last months to years
o More common in those > 60 years old
, Superficial Fungus
Pathophysiology & Epidemiology
• Infections by these fungi: o Microsporum o
Trichophyton o Epidermophyton
• These infections are called “tinea” followed by the skin
region they are infecting o Tinea captitis = scalp o
Tinea barbae = beard o Tinea faciei = face o Tinea
corporis = trunk o Tinea manus = hand o Tinea cruris =
groin o Tinea pedis = foot
Clinical Manifestations
• Red macules or plaques
• Feet may have vesicles
• Peripheral scaling and central clearing
Yeast Infections
Pathophysiology & Etiology
• Caused by the fungus candida albicans
• Fungal infection of external tissue
Clinical Manifestations
• Mouth – thrush
• Skin folds – intertrigo
• Systemic – mucocutaneous candidiasis
Impetigo
Pathophysiology & Etiology
• Bacterial skin infection caused by staphylococcus & streptococcus
• Staph is often carried in nasal area
• Very contagious
Clinical Manifestations
• Vesicles, pustules, and yellow crusts