PCB 3233 Immunology Final- Weigel
Questions and Answers Latest 2025 Top
Rated
mast cells
involved in allergic responses in tissue
eosinophils
Stain red
fight parasitic worm infections
basophils
stain with basic dyes (blue); controlling
immune responses to parasites
involved in allergic responses in blood
megakaryocyte
a bone marrow cell responsible for the
production of blood platelets when its
cytoplasm becomes fragmented
erythrocytes
Oxygen carrying cell (RBC)
antibodies (Abs)
,immunoglobulins;
- part of humoral immunity
MALT
defends mucosal surfaces lining of
digestive, respiratory and urogenital tracts
GALT
includes tonsils, adenoids, appendix and
Peyer's patches that line the gut
BALT
bronchial-associated lymphoid tissues
CR3 and CR4 recognize
iC3b
LPS
Factor P
binds to C3 convertase on microbial
surfaces and protects it from inhibition by
factor H
antimicrobial peptides
defensins, two types : alpha and beta;
secreted by epithelial cells - penetrates the
microbial membrane and disrupts it
,C-reactive Protein (CRP)
pentamer of identical subunits, binds to
phosphorycholine component of LPS; binds
with C1q
toll-like receptors (TLRs)
receptors or sensors for pathogen
components that signal macrophage to
make and secrete cytokines
TLR-4
senses ligand LPS; expressed on
macrophages; sends signal to the nucleus
of the macrophage to secrete inflammatory
cytokines as well as cytokines that activate
innate immune response
IL-1 beta and TNF-alpha
induces blood vessels to become more
permeable,
> effector cells and fluid containing soluble
effector molecules enter infected tissue
IL-6
, induces fat and muscle cells to metabolize
make heat
raise the temperature in the infected tissue
IL-1 beta, IL-6, TNF-alpha
pyrogens, inflammatory cytokines
CXCL8
= IL-8; recruits neutrophils from the blood
and guides them to the infected tissue
IL-12
recruits and activates NK cells that in turn
secrete cytokines that strengthen the
macrophages response to infection
NOD-Like receptors
cytoplasmic receptors for recognition of
pathogens
NOD-1
recognizes a degradation product of gram (-
) peptidoglycan
NOD-2
recognizes a degradation product of most
bacteria- murmyl dipeptide
Questions and Answers Latest 2025 Top
Rated
mast cells
involved in allergic responses in tissue
eosinophils
Stain red
fight parasitic worm infections
basophils
stain with basic dyes (blue); controlling
immune responses to parasites
involved in allergic responses in blood
megakaryocyte
a bone marrow cell responsible for the
production of blood platelets when its
cytoplasm becomes fragmented
erythrocytes
Oxygen carrying cell (RBC)
antibodies (Abs)
,immunoglobulins;
- part of humoral immunity
MALT
defends mucosal surfaces lining of
digestive, respiratory and urogenital tracts
GALT
includes tonsils, adenoids, appendix and
Peyer's patches that line the gut
BALT
bronchial-associated lymphoid tissues
CR3 and CR4 recognize
iC3b
LPS
Factor P
binds to C3 convertase on microbial
surfaces and protects it from inhibition by
factor H
antimicrobial peptides
defensins, two types : alpha and beta;
secreted by epithelial cells - penetrates the
microbial membrane and disrupts it
,C-reactive Protein (CRP)
pentamer of identical subunits, binds to
phosphorycholine component of LPS; binds
with C1q
toll-like receptors (TLRs)
receptors or sensors for pathogen
components that signal macrophage to
make and secrete cytokines
TLR-4
senses ligand LPS; expressed on
macrophages; sends signal to the nucleus
of the macrophage to secrete inflammatory
cytokines as well as cytokines that activate
innate immune response
IL-1 beta and TNF-alpha
induces blood vessels to become more
permeable,
> effector cells and fluid containing soluble
effector molecules enter infected tissue
IL-6
, induces fat and muscle cells to metabolize
make heat
raise the temperature in the infected tissue
IL-1 beta, IL-6, TNF-alpha
pyrogens, inflammatory cytokines
CXCL8
= IL-8; recruits neutrophils from the blood
and guides them to the infected tissue
IL-12
recruits and activates NK cells that in turn
secrete cytokines that strengthen the
macrophages response to infection
NOD-Like receptors
cytoplasmic receptors for recognition of
pathogens
NOD-1
recognizes a degradation product of gram (-
) peptidoglycan
NOD-2
recognizes a degradation product of most
bacteria- murmyl dipeptide
