PCB 3233 Exam 5 Questions and Answers
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What do Antibodies recruit?
"destructive, nonspecific" immune system components to
the infecting pathogen
How do antibodies recruit immune system
components?
Antibodies bind and link the pathogen to effector
molecules or cells that will destroy the pathogen
How do Antibodies fight?
1. Neutralize
2. Opsonize
3. Activate complement
4. Bind to Mast Cells and basophils
Can antibodies target and kill anything directly?
No, they only help lead to the destruction of the pathogen
but never kill anything directly
Can Antibodies bind to your own cell surface?
yes
If you have complement and opsonins on the surface
would that higher the chances of phagocytosis?
yes
What type of B-cells can be activated to become
plasma cells?
-Activated B-cells
-Centrocytes
-Memory B-cells
,A mature B-cell has what on its surface?
IgM and IgD
An immature B cell has what on it's surface?
IgM only
The majority of maturation for a B-cell takes place in
the...?
Bone Marrow
Final signal for B-cell maturation takes place in?
Secondary Lymphoid tissue.
Signal: BATH
What types of T-cells activates B-cells?
TH2 and TFH
TH2 Cells (CD4 T-Helper cell) makes what?
IgE
TFH Cells (T-follicular helper cell) is located where?
In the follicles
What does TH1 activate?
macrophages
Do most B-cells need T-cell help to be activated?
yes
Why are affinity maturation and Isotype switching
used? What is the purpose?
-Increased affinity: "longer bounded the more likely
associated with an antigen to get effector function to take
place."
-Isotype Switching: For correct effector function. Gain
effector function for the proper place.
, What does complement lead to?
Inflammation
Are antibodies opsonins directly?
Yes, Fc receptors bind directly.
Do B1(CD5) cells need T-cell help to become
activated?
No, because it is a Thymus independent cell
B1 cells are also known as
CD5
DiGeorge Syndrome
-deletion in chromosome 22 in which thymus fails to
develop and T-cells are absent
-have no thymus, therefore, lack T-cells to help activate
TD (Thymus Dependent) B-cells.
-Fewer B-cell activation
How does TI (Thymus independent) B-cells work?
Repetitive epithets react with multiple BCRs, engaging B-
cell activation
How does TD (Thymus dependent) B-cells work?
Needs at least 2 BCRs in close proximity, binding to
antigen, to get the kinase to phosphorylate ITAMs.
ITAMs
Immunoreceptor tyrosine-based activation motifs
Syk is analogous to what in T-cells?
Zap70
Blk Fyn and Lyn binds to
Ig(alpha) cytoplasmic tails
Latest 2025 Top Rated
What do Antibodies recruit?
"destructive, nonspecific" immune system components to
the infecting pathogen
How do antibodies recruit immune system
components?
Antibodies bind and link the pathogen to effector
molecules or cells that will destroy the pathogen
How do Antibodies fight?
1. Neutralize
2. Opsonize
3. Activate complement
4. Bind to Mast Cells and basophils
Can antibodies target and kill anything directly?
No, they only help lead to the destruction of the pathogen
but never kill anything directly
Can Antibodies bind to your own cell surface?
yes
If you have complement and opsonins on the surface
would that higher the chances of phagocytosis?
yes
What type of B-cells can be activated to become
plasma cells?
-Activated B-cells
-Centrocytes
-Memory B-cells
,A mature B-cell has what on its surface?
IgM and IgD
An immature B cell has what on it's surface?
IgM only
The majority of maturation for a B-cell takes place in
the...?
Bone Marrow
Final signal for B-cell maturation takes place in?
Secondary Lymphoid tissue.
Signal: BATH
What types of T-cells activates B-cells?
TH2 and TFH
TH2 Cells (CD4 T-Helper cell) makes what?
IgE
TFH Cells (T-follicular helper cell) is located where?
In the follicles
What does TH1 activate?
macrophages
Do most B-cells need T-cell help to be activated?
yes
Why are affinity maturation and Isotype switching
used? What is the purpose?
-Increased affinity: "longer bounded the more likely
associated with an antigen to get effector function to take
place."
-Isotype Switching: For correct effector function. Gain
effector function for the proper place.
, What does complement lead to?
Inflammation
Are antibodies opsonins directly?
Yes, Fc receptors bind directly.
Do B1(CD5) cells need T-cell help to become
activated?
No, because it is a Thymus independent cell
B1 cells are also known as
CD5
DiGeorge Syndrome
-deletion in chromosome 22 in which thymus fails to
develop and T-cells are absent
-have no thymus, therefore, lack T-cells to help activate
TD (Thymus Dependent) B-cells.
-Fewer B-cell activation
How does TI (Thymus independent) B-cells work?
Repetitive epithets react with multiple BCRs, engaging B-
cell activation
How does TD (Thymus dependent) B-cells work?
Needs at least 2 BCRs in close proximity, binding to
antigen, to get the kinase to phosphorylate ITAMs.
ITAMs
Immunoreceptor tyrosine-based activation motifs
Syk is analogous to what in T-cells?
Zap70
Blk Fyn and Lyn binds to
Ig(alpha) cytoplasmic tails
