APHA Immunization Exam Prep 2025/2026 –
Study Guide With Review Questions
Section 1: Vaccine Schedules & Recommendations
1. According to the CDC/ACIP, what is the standard recommended interval between
two inactivated vaccines if they are not administered simultaneously?
A) 14 days
B) 28 days
C) 7 days
✓ D) There is no minimum interval; they can be administered at any time.
Explanation: Inactivated vaccines do not interfere with each other and can be administered at
any time before, after, or simultaneously with other inactivated or live vaccines.
2. A healthy 2-month-old infant presents for their first well-child visit. Which of the following
vaccines should be administered?
A) MMR, Varicella
B) HPV, Tdap
C) PCV15, RIV
✓ D) DTaP, IPV, Hib, HepB, RV, PCV15
*Explanation: The CDC schedule for a 2-month-old includes doses of DTaP, IPV, Hib, HepB (if not
given at birth), Rotavirus, and Pneumococcal conjugate vaccine (PCV15 or PCV20).*
3. A 16-year-old adolescent has no record of receiving a Tdap vaccine. What is the correct
action?
A) Administer Tdap now and a booster in 10 years.
B) Administer Td only, as pertussis is not a concern for this age group.
✓ C) Administer a single dose of Tdap now, followed by Td or Tdap boosters every 10 years.
*Explanation: All adolescents should receive a single dose of Tdap at age 11-12 years. If missed,
it should be administered as soon as possible. Subsequent boosters are recommended every 10
years with Td or Tdap.*
4. Which vaccine is recommended annually for all persons aged 6 months and older, without
contraindications?
A) Pneumococcal polysaccharide (PPSV23)
B) COVID-19
✓ C) Influenza (IIV, RIV, or LAIV)
, D) Meningococcal B (MenB)
Explanation: Annual influenza vaccination is recommended for everyone 6 months and older.
5. A 50-year-old adult with no known risk factors asks about the shingles vaccine. Which
recommendation is correct?
✓ A) Administer 2 doses of recombinant zoster vaccine (RZV, Shingrix) 2-6 months apart.
B) Administer 1 dose of live zoster vaccine (ZVL, Zostavax).
C) They are not eligible until age 60.
D) Administer 1 dose of RZV.
Explanation: The CDC recommends 2 doses of RZV (Shingrix) for immunocompetent adults aged
50 years and older, regardless of prior shingles history or receipt of ZVL.
6. The MMR vaccine is first recommended at what age?
A) Birth
B) 6 months
✓ C) 12 months
D) 4-6 years
*Explanation: The first dose of MMR is routinely given at 12-15 months of age. An earlier dose is
not considered valid.*
7. A 26-year-old female has not completed the HPV vaccine series. What is the current ACIP
recommendation?
A) She is too old; no vaccination is recommended.
B) Administer a single dose only.
✓ C) Administer a 2-dose series (0, 6-12 months) if the series was started before age 15, or a 3-
dose series (0, 1-2, 6 months) if started at or after age 15.
D) Administer a 3-dose series regardless of age at initiation.
*Explanation: Catch-up HPV vaccination is recommended for all persons through age 26. The
number of doses depends on the age at which the series was initiated.*
8. Which of the following is a contraindication to receiving the live attenuated influenza
vaccine (LAIV)?
A) Egg allergy
B) Age over 65 years
✓ C) Pregnancy
D) History of Guillain-Barré Syndrome (GBS)
*Explanation: Pregnancy is a contraindication for LAIV. LAIV is also not recommended for
immunocompromised persons or children 2-4 years old with asthma/wheezing.*
Study Guide With Review Questions
Section 1: Vaccine Schedules & Recommendations
1. According to the CDC/ACIP, what is the standard recommended interval between
two inactivated vaccines if they are not administered simultaneously?
A) 14 days
B) 28 days
C) 7 days
✓ D) There is no minimum interval; they can be administered at any time.
Explanation: Inactivated vaccines do not interfere with each other and can be administered at
any time before, after, or simultaneously with other inactivated or live vaccines.
2. A healthy 2-month-old infant presents for their first well-child visit. Which of the following
vaccines should be administered?
A) MMR, Varicella
B) HPV, Tdap
C) PCV15, RIV
✓ D) DTaP, IPV, Hib, HepB, RV, PCV15
*Explanation: The CDC schedule for a 2-month-old includes doses of DTaP, IPV, Hib, HepB (if not
given at birth), Rotavirus, and Pneumococcal conjugate vaccine (PCV15 or PCV20).*
3. A 16-year-old adolescent has no record of receiving a Tdap vaccine. What is the correct
action?
A) Administer Tdap now and a booster in 10 years.
B) Administer Td only, as pertussis is not a concern for this age group.
✓ C) Administer a single dose of Tdap now, followed by Td or Tdap boosters every 10 years.
*Explanation: All adolescents should receive a single dose of Tdap at age 11-12 years. If missed,
it should be administered as soon as possible. Subsequent boosters are recommended every 10
years with Td or Tdap.*
4. Which vaccine is recommended annually for all persons aged 6 months and older, without
contraindications?
A) Pneumococcal polysaccharide (PPSV23)
B) COVID-19
✓ C) Influenza (IIV, RIV, or LAIV)
, D) Meningococcal B (MenB)
Explanation: Annual influenza vaccination is recommended for everyone 6 months and older.
5. A 50-year-old adult with no known risk factors asks about the shingles vaccine. Which
recommendation is correct?
✓ A) Administer 2 doses of recombinant zoster vaccine (RZV, Shingrix) 2-6 months apart.
B) Administer 1 dose of live zoster vaccine (ZVL, Zostavax).
C) They are not eligible until age 60.
D) Administer 1 dose of RZV.
Explanation: The CDC recommends 2 doses of RZV (Shingrix) for immunocompetent adults aged
50 years and older, regardless of prior shingles history or receipt of ZVL.
6. The MMR vaccine is first recommended at what age?
A) Birth
B) 6 months
✓ C) 12 months
D) 4-6 years
*Explanation: The first dose of MMR is routinely given at 12-15 months of age. An earlier dose is
not considered valid.*
7. A 26-year-old female has not completed the HPV vaccine series. What is the current ACIP
recommendation?
A) She is too old; no vaccination is recommended.
B) Administer a single dose only.
✓ C) Administer a 2-dose series (0, 6-12 months) if the series was started before age 15, or a 3-
dose series (0, 1-2, 6 months) if started at or after age 15.
D) Administer a 3-dose series regardless of age at initiation.
*Explanation: Catch-up HPV vaccination is recommended for all persons through age 26. The
number of doses depends on the age at which the series was initiated.*
8. Which of the following is a contraindication to receiving the live attenuated influenza
vaccine (LAIV)?
A) Egg allergy
B) Age over 65 years
✓ C) Pregnancy
D) History of Guillain-Barré Syndrome (GBS)
*Explanation: Pregnancy is a contraindication for LAIV. LAIV is also not recommended for
immunocompromised persons or children 2-4 years old with asthma/wheezing.*
