UST ABSN Pathopharmacology 1 EXAM QUESTIONS WITH ANSWERS

UST ABSN Pathopharmacology 1
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EXAM QUESTIONS WITH ANSWERS |\ |\ |\




A drug is any chemical that can affect living processes -
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CORRECT ANSWERS ✔✔How do you define the word drug?
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Pharmacology can be defined as the study of drugs and their |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\


interaction with living things - CORRECT ANSWERS ✔✔Define
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pharmacology


study of effect of drugs in man (as compared to animals or
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comparative pharmacology - CORRECT ANSWERS ✔✔Define |\ |\ |\ |\ |\ |\


clinical pharmacology |\




also known as therapeutics, pharmacotherapeutics emphasizes
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the disease state and its characteristics including therapy for and
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use of drugs in prevention and treatment of condition - CORRECT
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ANSWERS ✔✔what are pharmacotherapeutics?
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Drugs used to destroy or eliminate pathogenic cells or organisms.
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The term is usually restricted to anti-infectives and cancer
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chemotherapy. - CORRECT ANSWERS ✔✔what are |\ |\ |\ |\ |\ |\


chemotherapeutic agents? |\




Toxicology deals with the effects of drugs. Toxicity is measured
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through the Therapeutic Index. - CORRECT ANSWERS ✔✔what is
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toxicology and how do we measure a drugs toxicity?
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,therapeutic index is a ratio that measures toxicity. The ratio is
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found by putting the dose *capable of killing 50% of animals
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(LD50) over than required to acheive a beneficial effect in 50% of
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animals (ED50).
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In clinical practice the THERAPEUTIC INDEX is described as the
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ratio of the dose that causes toxicity over the dose that provides
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therapeutic effect. - CORRECT ANSWERS ✔✔What is the |\ |\ |\ |\ |\ |\ |\ |\


therapeutic index? |\




Tolerance is the hyporeactivity that occurring from chronic
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exposure to a drug. Achievement of the same effects of the drug
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requires larger and larger doses. - CORRECT ANSWERS ✔✔what is
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tolerance?
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Cross tolerance may happen when tolerance occurs across drugs
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of the same class or across drugs that have the same
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pharmacological effects - CORRECT ANSWERS ✔✔What is cross |\ |\ |\ |\ |\ |\ |\ |\


tolerance and how does it occur? |\ |\ |\ |\ |\




Tolerance to opioids, barbiturates, and alcohol - CORRECT
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ANSWERS ✔✔what are some examples of neurological
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adaptation/ cellular tolerance to drugs? |\ |\ |\ |\




metabolic drug tolerance occurs when the body has an increased
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rate of elimination of the drug. - CORRECT ANSWERS ✔✔What is
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metabolic drug tolerance? |\ |\

, enzyme induction which occurs when there is an increased
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activity of enzymes (the drug transport system) - CORRECT
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ANSWERS ✔✔what is the most common form of metabolic |\ |\ |\ |\ |\ |\ |\ |\ |\


tolerance?


pharmacodynamic processes determine the nature and intensity |\ |\ |\ |\ |\ |\ |\


of the response. It is essentially the effect of the drug ON the
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body.


EX: Target Organ, receptors, proteins, physiological effect etc. -
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CORRECT ANSWERS ✔✔What is pharmacodynamics? |\ |\ |\ |\




Pharmacokinetic processes determine how much of an admin- |\ |\ |\ |\ |\ |\ |\ |\


istered dose gets to its sites of action. There are four major
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pharmacokinetic processes: (1) drug absorption, (2) drug |\ |\ |\ |\ |\ |\ |\


distribution, (3) drug metabolism, and (4) drug excretion. *These |\ |\ |\ |\ |\ |\ |\ |\ |\


processes can be thought of as the impact of the body on drugs*
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- CORRECT ANSWERS ✔✔What is pharmacokinetics?
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what are the four major pharmacokinetic processes?
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Down regulation - CORRECT ANSWERS ✔✔what type of tolerance
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occurs when there is a decrease in the number, or decrease in
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the sensitivity, of receptor sites?
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betablockers - CORRECT ANSWERS ✔✔what kind of drugs block |\ |\ |\ |\ |\ |\ |\ |\ |\


receptors?