UPDATE!!!!!2025/2026|GUARANTEED
Define neoadjuvant therapy - ANSWER Treatment is given prior to surgery to shrink
the tumor
Define adjuvant therapy - ANSWER Additional cancer treatment given after the
primary treatment to lower the risk that the cancer reoccur
3 subcategories of alkylating agents: - ANSWER 1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as
they work similarly)
3. Nitrosoureas
Common alkylating agents: - ANSWER Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: - ANSWER Cisplatin (Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? - ANSWER Able to cross the blood-brain
barrier; can be effective in treating some brain tumors
1
,Common nitrosoureas agents: - ANSWER Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - ANSWER Carboplatin
These agents are typically categorized as highly emetogenic: - ANSWER 1. Alkylating
agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - ANSWER BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - ANSWER Bladder protectant with
administration of cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-
4 days following treatment - ANSWER Oxaliplatin
How do antimetabolites function? - ANSWER By blocking DNA and RNA growth by
interfering with enzymes needed for normal cell metabolism
Antimetabolites work in the ___ phase. - ANSWER S
Common side effects of antimetabolites: - ANSWER Myelosuppression
GI toxicities
Photosensitivity
2
, Hand-foot syndrome
Common antimetabolite drugs: - ANSWER Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
The institute for Safe Medication Practices recommends what route of administration for
vincristine? - ANSWER IV piggyback via gravity
Anthracycline antitumor abx work by: - ANSWER Interfering with enzymes necessary
for DNA to replicate in ALL phases of the cell cycle
The two major classifications of antitumor antibiotics are: - ANSWER Anthracyclines
Non-anthracyclines
Common anthracycline antitumor abx: - ANSWER Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
The antitumor abx ___________ is not an anthracycline, but has anthracycline-type
properties. - ANSWER Mitoxantrone
Common non-anthracycline antitumor abx: - ANSWER Actinomycin D
Mitomycin C
3
Define neoadjuvant therapy - ANSWER Treatment is given prior to surgery to shrink
the tumor
Define adjuvant therapy - ANSWER Additional cancer treatment given after the
primary treatment to lower the risk that the cancer reoccur
3 subcategories of alkylating agents: - ANSWER 1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as
they work similarly)
3. Nitrosoureas
Common alkylating agents: - ANSWER Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: - ANSWER Cisplatin (Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? - ANSWER Able to cross the blood-brain
barrier; can be effective in treating some brain tumors
1
,Common nitrosoureas agents: - ANSWER Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - ANSWER Carboplatin
These agents are typically categorized as highly emetogenic: - ANSWER 1. Alkylating
agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - ANSWER BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - ANSWER Bladder protectant with
administration of cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-
4 days following treatment - ANSWER Oxaliplatin
How do antimetabolites function? - ANSWER By blocking DNA and RNA growth by
interfering with enzymes needed for normal cell metabolism
Antimetabolites work in the ___ phase. - ANSWER S
Common side effects of antimetabolites: - ANSWER Myelosuppression
GI toxicities
Photosensitivity
2
, Hand-foot syndrome
Common antimetabolite drugs: - ANSWER Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
The institute for Safe Medication Practices recommends what route of administration for
vincristine? - ANSWER IV piggyback via gravity
Anthracycline antitumor abx work by: - ANSWER Interfering with enzymes necessary
for DNA to replicate in ALL phases of the cell cycle
The two major classifications of antitumor antibiotics are: - ANSWER Anthracyclines
Non-anthracyclines
Common anthracycline antitumor abx: - ANSWER Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
The antitumor abx ___________ is not an anthracycline, but has anthracycline-type
properties. - ANSWER Mitoxantrone
Common non-anthracycline antitumor abx: - ANSWER Actinomycin D
Mitomycin C
3
