Pharmacology
psychiatric mental
health nurse
practitioner
What are the five factors that influence absorption? - answer-gastric emptying
Time of contact with intestinal wall
Bowel perfusion
Food
Formation of non-absorbable complexes
Explain the hepatic first pass. - answer-part of the drug is metabolized by the liver before it
reaches the blood.
Explain bioavailability. - answer-percentage of administered drug that reaches systemic
circulation.
Name the 3 highly water-soluble drugs. - answer-lithium, amisulpride, paliperidone
, What are the 7 inhibitors of cyp? - answer-paroxetine, fluoxetine, fluvoxamine, fluconazole,
ciprofloxacin, ritonavir, grapefruit juice
What are the 6 inducers of cyp? - answer-carbamazepine, phenytoin, phenobarbital, primidone,
smoking, st-john's wort
What are the 6 factors that influence pharmacokinetics? - answer-age, pregnancy, obesity, sexe,
comorbidities, genetics
Explain the half-life. - answer-the time it takes for the concentration of a drug to be reduced by
50%
What are the 11 indications for tdm. - answer-non-compliance/toxicity
Lack of efficacy/adverse effects at normal dose
Relapse in maintenance treatment
Change in drug formulation
Pregnancy
Age
Comorbidities
Drug interactions
Change in bmi
Finding the optimal drug concentration
Genetic polymorphisms
What are the 4 factors influencing receptor binding? - answer-affinity
Specificity
Saturability
psychiatric mental
health nurse
practitioner
What are the five factors that influence absorption? - answer-gastric emptying
Time of contact with intestinal wall
Bowel perfusion
Food
Formation of non-absorbable complexes
Explain the hepatic first pass. - answer-part of the drug is metabolized by the liver before it
reaches the blood.
Explain bioavailability. - answer-percentage of administered drug that reaches systemic
circulation.
Name the 3 highly water-soluble drugs. - answer-lithium, amisulpride, paliperidone
, What are the 7 inhibitors of cyp? - answer-paroxetine, fluoxetine, fluvoxamine, fluconazole,
ciprofloxacin, ritonavir, grapefruit juice
What are the 6 inducers of cyp? - answer-carbamazepine, phenytoin, phenobarbital, primidone,
smoking, st-john's wort
What are the 6 factors that influence pharmacokinetics? - answer-age, pregnancy, obesity, sexe,
comorbidities, genetics
Explain the half-life. - answer-the time it takes for the concentration of a drug to be reduced by
50%
What are the 11 indications for tdm. - answer-non-compliance/toxicity
Lack of efficacy/adverse effects at normal dose
Relapse in maintenance treatment
Change in drug formulation
Pregnancy
Age
Comorbidities
Drug interactions
Change in bmi
Finding the optimal drug concentration
Genetic polymorphisms
What are the 4 factors influencing receptor binding? - answer-affinity
Specificity
Saturability
