NR566 FINAL (ADVANCED
PHARMACOLOGY FOR CARE OF THE
FAMILY) EXAM QUESTIONS &
DETAILED CORRECT ANSWERS
Anti-Androgens - correct answer ✔✔Finasteride (Propecia)
Leuprolide (Eligard, Lupron, Lupron Depot)
Spironolactone (Aldactone)
Finasteride (Propecia, Proscar) - correct answer ✔✔blocks conversion of testosterone to
dihydrotesterone
Used to tx:
-BPH
-male pattern baldness
3 months of therapy need to see benefits
Stopping, reverses effect w/in 12 months
Adverse side effects:
- Decreased libido
-Impotence
dutasteride (Avodart) - correct answer ✔✔5-alpha reductase inhibitor
used to tx:
BPH
,Can stay in serum up to 6 mon after discontinuing
can be absorbed through skin
pregnant woman shouldn't handle capsules
(fetal anomaly in male fetus)
Adverse Effects
decreased libido
Impotence
Leuprolide Acetate (Lupron) - correct answer ✔✔Luteinizing hormone - releasing agonist
create reversible:
-orchiectomy state
-oophorectomy state
Used to tx:
- advanced prostatic cancer
- Management of endometriosis
- Uterine fibroids
- polycystic ovarian disease
- central precocious puberty in peds
Flutamide (Eulexin, Euflex) - correct answer ✔✔Truly non-steroidal agent
Used to tx:
-Advanced prostate cancer
, -female androgen excess syndrome
Adverse Effects in males
- gynecomastia
-reversible liver toxicity
Black Box Warning
-hepatic failure
-hepatic encephalopathy
Basline/monthly liver function test for 1st 4 months
Spironolactone (Aldactone) - correct answer ✔✔aldosterone antagonist
potassium sparing diuretic
used for tx:
-female hirsutism (abnormal growth of hair)
-acne
-relief of PMS/PMDD symptoms (25-50 mg/d)
Adverse reactions
- dose related + reversible when discont.
-GI upset
-Drowsiness
-Gynecomastia
-Impotence
-Cutaneous (skin) eruptions
PHARMACOLOGY FOR CARE OF THE
FAMILY) EXAM QUESTIONS &
DETAILED CORRECT ANSWERS
Anti-Androgens - correct answer ✔✔Finasteride (Propecia)
Leuprolide (Eligard, Lupron, Lupron Depot)
Spironolactone (Aldactone)
Finasteride (Propecia, Proscar) - correct answer ✔✔blocks conversion of testosterone to
dihydrotesterone
Used to tx:
-BPH
-male pattern baldness
3 months of therapy need to see benefits
Stopping, reverses effect w/in 12 months
Adverse side effects:
- Decreased libido
-Impotence
dutasteride (Avodart) - correct answer ✔✔5-alpha reductase inhibitor
used to tx:
BPH
,Can stay in serum up to 6 mon after discontinuing
can be absorbed through skin
pregnant woman shouldn't handle capsules
(fetal anomaly in male fetus)
Adverse Effects
decreased libido
Impotence
Leuprolide Acetate (Lupron) - correct answer ✔✔Luteinizing hormone - releasing agonist
create reversible:
-orchiectomy state
-oophorectomy state
Used to tx:
- advanced prostatic cancer
- Management of endometriosis
- Uterine fibroids
- polycystic ovarian disease
- central precocious puberty in peds
Flutamide (Eulexin, Euflex) - correct answer ✔✔Truly non-steroidal agent
Used to tx:
-Advanced prostate cancer
, -female androgen excess syndrome
Adverse Effects in males
- gynecomastia
-reversible liver toxicity
Black Box Warning
-hepatic failure
-hepatic encephalopathy
Basline/monthly liver function test for 1st 4 months
Spironolactone (Aldactone) - correct answer ✔✔aldosterone antagonist
potassium sparing diuretic
used for tx:
-female hirsutism (abnormal growth of hair)
-acne
-relief of PMS/PMDD symptoms (25-50 mg/d)
Adverse reactions
- dose related + reversible when discont.
-GI upset
-Drowsiness
-Gynecomastia
-Impotence
-Cutaneous (skin) eruptions
