NR 566 WEEK 2- ADVANCED
PHARMACOLOGY FOR CARE OF
FAMILY- ABX EXAM QUESTIONS &
COMPLETE CORRECT ANSWERS
Penicillin are only active against bacteria that are undergoing ___________ and
______________
growth
division
bacterial resistance in penicillins is determined by 3 factors:
1. ___________ of penicillins by bacterial enzymes
2. production of penicillin binding proteins that have a ___ affinity for penicillins
3. inability of ___________ to reach their targets
inactivation
low
penicllins
describe gram negative penicillin activity:
only certain penicillins like ___________ are able to cross it to reach penicillin binding protein
on cytoplasmic membrane
there are 3 layers:
1.cytoplasmic membrane
,2. _____ cell wall
3. additional outer membrane
ampicillin
thin
the main difference in Pen G and Pen V is ______ __________
Pen _ is stable in the stomach, Pen _ is not.
acid stability
V
G
Pen _ can be given PO, with meals
V
Cephalosporins are _______________, they bind to penicillin binding proteins, disrupt cell wall
synthesis, and activate __________, --> cell death
bactericidal
autolysins
Cephalosporins are most effective against cells undergoing _________ and _________
growth
division
, __________ and ____________ induce alcohol intolerance
if pt were to drink alcohol while on either abx, they could have a ________-like reaction,
dangerous! s/s: HoTN, ________, HA
cefazolin; cefotetan
disulfram; palpitations
(cephalosporins)
____________, ______________, and _____________ can increase bleeding because they have
a side chain that interfere with vitamin __ metabolism stopping __________ factor from
forming
Cefotetan, cefazolin, ceftriaxone
vitamin K
clotting
be careful using meds with other drugs that promote bleeding ex: warfarin, digoxin, NSAIDs,
antiplatelets
The nucleus of the cephalosporins bacteria has ____ ________, which is required for
antibacterial activity
beta lactam
PHARMACOLOGY FOR CARE OF
FAMILY- ABX EXAM QUESTIONS &
COMPLETE CORRECT ANSWERS
Penicillin are only active against bacteria that are undergoing ___________ and
______________
growth
division
bacterial resistance in penicillins is determined by 3 factors:
1. ___________ of penicillins by bacterial enzymes
2. production of penicillin binding proteins that have a ___ affinity for penicillins
3. inability of ___________ to reach their targets
inactivation
low
penicllins
describe gram negative penicillin activity:
only certain penicillins like ___________ are able to cross it to reach penicillin binding protein
on cytoplasmic membrane
there are 3 layers:
1.cytoplasmic membrane
,2. _____ cell wall
3. additional outer membrane
ampicillin
thin
the main difference in Pen G and Pen V is ______ __________
Pen _ is stable in the stomach, Pen _ is not.
acid stability
V
G
Pen _ can be given PO, with meals
V
Cephalosporins are _______________, they bind to penicillin binding proteins, disrupt cell wall
synthesis, and activate __________, --> cell death
bactericidal
autolysins
Cephalosporins are most effective against cells undergoing _________ and _________
growth
division
, __________ and ____________ induce alcohol intolerance
if pt were to drink alcohol while on either abx, they could have a ________-like reaction,
dangerous! s/s: HoTN, ________, HA
cefazolin; cefotetan
disulfram; palpitations
(cephalosporins)
____________, ______________, and _____________ can increase bleeding because they have
a side chain that interfere with vitamin __ metabolism stopping __________ factor from
forming
Cefotetan, cefazolin, ceftriaxone
vitamin K
clotting
be careful using meds with other drugs that promote bleeding ex: warfarin, digoxin, NSAIDs,
antiplatelets
The nucleus of the cephalosporins bacteria has ____ ________, which is required for
antibacterial activity
beta lactam
