EKU NSC 830 Adv Pharm Questions With Complete
Solutions
A function of Metabolism: Correct Answers Changing from an
active metabolite to an inactive metabolite OR changing from an
inactive metabolite to an active metabolite.
Bound drug molecules are considered Correct Answers inactive
Distribution Correct Answers Drug movement from the blood
to tissues and cells
Elimination Correct Answers movement or excretion of drugs
out of the body
Equilibrium Correct Answers the steady state found between
the tissue and the serum concentration after 4-5 half-lives of a
drug
How are fluids and solutes passed across the glomerular
membrane during glomerular filtration? Correct Answers
Passive diffusion
How much does a healthy adult excrete through glomerulur
filtration Correct Answers 130ml/min
If a drug is administered as an inactive pro-drug what must
happen for the drug to have an effect? Correct Answers The
drug must be metabolized to an active metabolite from the
inactive pro-drug state to have an effect
, If a drug molecules is bound to plasma protein, why is it
considered inactive? Correct Answers It is too big to cross over
into the tissues from the plasma
If conjugates are broken down by enzymes in the gut bacteria
what happens to the drug? Correct Answers the drug is liberated
and reabsorbed into the body through intestinal reabsorption
If drugs or conjugated metabolites are excreted in the bile what
happens for elimination? Correct Answers They enter the GI
tract and are excreted in feces
In order for drugs to cross the Blood Brain Barrier they must be:
Correct Answers Un-ionized, small molecules, and lipid
soluable
in order for drugs to pass the placental barrier they must be:
Correct Answers Lipid soluable, smaller molecule drugs, and
there must be passive diffusion
Inducer Correct Answers a drug that induces or increases the
activity of the CYP450 system
Inhibitor Correct Answers a drug that inhibits or decreases the
activity of the CYP450 system
Maximum therapeutic effects of a drug do not happen until this
happens Correct Answers Equilibrium
Metabolism Correct Answers the process of chemically
changing a drug to a different compound called a metabolite
Solutions
A function of Metabolism: Correct Answers Changing from an
active metabolite to an inactive metabolite OR changing from an
inactive metabolite to an active metabolite.
Bound drug molecules are considered Correct Answers inactive
Distribution Correct Answers Drug movement from the blood
to tissues and cells
Elimination Correct Answers movement or excretion of drugs
out of the body
Equilibrium Correct Answers the steady state found between
the tissue and the serum concentration after 4-5 half-lives of a
drug
How are fluids and solutes passed across the glomerular
membrane during glomerular filtration? Correct Answers
Passive diffusion
How much does a healthy adult excrete through glomerulur
filtration Correct Answers 130ml/min
If a drug is administered as an inactive pro-drug what must
happen for the drug to have an effect? Correct Answers The
drug must be metabolized to an active metabolite from the
inactive pro-drug state to have an effect
, If a drug molecules is bound to plasma protein, why is it
considered inactive? Correct Answers It is too big to cross over
into the tissues from the plasma
If conjugates are broken down by enzymes in the gut bacteria
what happens to the drug? Correct Answers the drug is liberated
and reabsorbed into the body through intestinal reabsorption
If drugs or conjugated metabolites are excreted in the bile what
happens for elimination? Correct Answers They enter the GI
tract and are excreted in feces
In order for drugs to cross the Blood Brain Barrier they must be:
Correct Answers Un-ionized, small molecules, and lipid
soluable
in order for drugs to pass the placental barrier they must be:
Correct Answers Lipid soluable, smaller molecule drugs, and
there must be passive diffusion
Inducer Correct Answers a drug that induces or increases the
activity of the CYP450 system
Inhibitor Correct Answers a drug that inhibits or decreases the
activity of the CYP450 system
Maximum therapeutic effects of a drug do not happen until this
happens Correct Answers Equilibrium
Metabolism Correct Answers the process of chemically
changing a drug to a different compound called a metabolite
