Psychopharmacology Drugs the Brain And Behavior 3rd Edition meyer Nursing
Test Bank
Psychopharmacology Drugs the Brain And Behavior 3rd Edition meyer Nursing
Test Bank
Test Bank
to accompany
Psychopharmacology, Third Edition
Meyer • Quenzer
Chapter 1: Principles of Pharmacology
Multiple Choice
1. refer(s) to specific molecular changes that occur when a drug binds to a
particular target site or receptor, while are the resulting widespread alterations
in function.
a. Drug action; therapeutic effects
b. Side effects; drug effects
c. Therapeutic effects; side effects
d. Drug action; drug effects
Answer: d
Textbook Reference: Pharmacology: The Science of Drug Action
2. After drug administration has occurred, the amount of drug in the blood that is free to
bind at specific target sites is referred to as
a. the therapeutic dose.
b. first-pass effects.
c. bioavailability.
d. ED50.
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
3. The specific molecular changes that occur when a drug binds to a particular target site
or receptor are referred to as
a. drug effects.
b. drug action.
c. side effects.
d. placebo effects.
Answer: b
Textbook Reference: Pharmacology: The Science of Drug Action
4. Which of the following is not a possible explanation for placebo effects?
a. Pavlovian conditioning
b. Genetic variation
c. Drug competition
d. Expectation of outcome
Answer: c
Textbook Reference: Pharmacology: The Science of Drug Action
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5. The administration of oxytocin has been proposed as a treatment for autism. Answer: c
a. intravenous Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b. oral
c. intranasal 11. Drugs administered _ have the most rapid onset of action.
d. intracerebral a. subcutaneously
Answer: c b. intramuscularly
Textbook Reference: Pharmacokinetic Factors Determining Drug Action c. orally
d. intravenously
6. Which factor does not affect the pharmacokinetics of a drug? Answer: d
a. Route of administration Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b. Lipid solubility
c. Depot binding 12. Ionization of a drug depends on the of the solution and the of the
d. Drug action drug.
Answer: d a. pH; pKa
Textbook Reference: Pharmacokinetic Factors Determining Drug Action b. pKa; pH
c. concentration; lipid solubility
7. First-pass metabolism occurs when drugs are taken d. pH; concentration
a. orally. Answer: a
b. intravenously. Textbook Reference: Pharmacokinetic Factors Determining Drug Action
c. subcutaneously.
d. nasally. 13. The absorption of a drug depends on all of the following except
Answer: a a. lipid solubility.
Textbook Reference: Pharmacokinetic Factors Determining Drug Action b. ionization.
c. body temperature.
8. The area postrema is one area in the brain where the is not complete. d. the concentration of the drug.
a. cerebrospinal fluid Answer: c
b. blood–brain barrier Textbook Reference: Pharmacokinetic Factors Determining Drug Action
c. choroid plexus
d. phospholipid membrane 14. Drugs that are should be avoided by women of childbearing age.
Answer: b a. teratogenic
Textbook Reference: Pharmacokinetic Factors Determining Drug Action b. able to cross the placental barrier
c. psychoactive
9. First-pass metabolism occurs with orally administered drugs because d. highly lipid-soluble
a. their absorption is slowed by food. Answer: a
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to Textbook Reference: Pharmacokinetic Factors Determining Drug Action
general circulation.
c. drugs must first survive the acidic environment of the stomach. 15. Agents that induce developmental abnormalities in a fetus are known as
d. salivary enzymes in the mouth begin the process of metabolism. a. psychoactive drugs.
Answer: b b. illicit drugs.
Textbook Reference: Pharmacokinetic Factors Determining Drug Action c. teratogens.
d. placental drugs.
10. Toxic substances in the blood trigger a vomiting response by activating the Answer: c
a. blood–brain barrier. Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b. choroid plexus.
c. area postrema. 16. Depot binding is said to occur when drugs
d. median eminence. a. bind to their target sites.
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b. bind to inactive sites. Answer: c
c. compete for binding sites. Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d. are excreted before binding.
Answer: b 22. Biotransformation of drugs can result in the formation of , which enter the
Textbook Reference: Pharmacokinetic Factors Determining Drug Action circulation and cause .
a. inactive metabolites; sensitization
17. Which statement about depot binding is false? b. active metabolites; prolonged drug action
a. It reduces the concentration of drug at its site of action. c. active metabolites; tolerance
b. It may delay the onset of drug action. d. enzymes; tolerance
c. It may prolong drug action by disrupting normal metabolism. Answer: b
d. It increases the concentration of drug at its site of action by releasing large quantities at Textbook Reference: Pharmacokinetic Factors Determining Drug Action
once.
Answer: d 23. Which statement about water-soluble metabolites formed in the liver is false?
Textbook Reference: Pharmacokinetic Factors Determining Drug Action a. They may return to the circulation and act on target tissues.
b. They may be filtered out by the kidneys.
18. Drug metabolism mostly occurs in the and usually makes a drug more c. They may be excreted into bile.
soluble. d. They may be eliminated with the feces.
a. kidneys; fat Answer: a
b. liver; fat Textbook Reference: Pharmacokinetic Factors Determining Drug Action
c. liver; water
d. kidneys; water 24. Which statement about microsomal enzymes in the liver is false?
Answer: c a. They are highly specific and act only on certain compounds.
Textbook Reference: Pharmacokinetic Factors Determining Drug Action b. They are located on the smooth endoplasmic reticulum.
c. The cytochrome P450 family is one of the most important.
19. Which statement about drug clearance by first-order kinetics is false? d. They can metabolize toxins and environmental pollutants as well as drugs.
a. Molecules of a drug are cleared at a constant rate regardless of drug concentration. Answer: a
b. Molecules of a drug are cleared at an exponential rate. Textbook Reference: Pharmacokinetic Factors Determining Drug Action
c. A constant fraction of the free drug in the blood is removed in each time interval.
d. Clearance of most drugs occurs in this manner. 25. Repeated use of many psychoactive drugs can cause , which can speed up the
Answer: a rate of biotransformation of these drugs as well as others.
Textbook Reference: Pharmacokinetic Factors Determining Drug Action a. drug competition
b. enzyme inhibition
20. Ethyl alcohol (ethanol) is an example of a drug that is eliminated c. enzyme induction
a. by first-order kinetics. d. tolerance
b. by zero-order kinetics. Answer: c
c. by second-order kinetics. Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d. at the point that six half-lives have passed.
Answer: b 26. Due to , antidepressants known as monoamine oxidase inhibitors (MAOIs)
Textbook Reference: Pharmacokinetic Factors Determining Drug Action can cause cardiac arrhythmias and high blood pressure in patients that consume foods
high in tyramine.
21. Biotransformation of drugs in the liver often occurs in two stages; phase I changes are a. sensitization
and include . b. tolerance
a. nonsynthetic; conjugation c. drug competition
b. synthetic; conjugation d. enzyme inhibition
c. nonsynthetic; oxidation Answer: d
d. synthetic; oxidation Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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a. intracellular receptors.
27. While drugs can be excreted from the body by several routes, the most important b. membrane-bound receptors.
route of elimination is through the c. protein synthesis.
a. breath. d. second messengers.
b. sweat. Answer: b
c. feces. Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions
d. urine.
Answer: d 33. While most receptors are membrane-bound on the cell surface, many
Textbook Reference: Pharmacokinetic Factors Determining Drug Action receptors are intracellular.
a. drug; neurotransmitter
28. The liver and kidneys work together to _ and drugs, respectively. b. hormone; drug
a. metabolize; excrete c. neurotransmitter; hormone
b. excrete; metabolize d. agonist; antagonist
c. bind; metabolize Answer: c
d. absorb; excrete Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions
Answer: a
Textbook Reference: Pharmacokinetic Factors Determining Drug Action 34. Ligands that have no effect on a receptor after binding are called
a. antagonists.
29. For drugs that have a narrow therapeutic window or potentially serious side effects, b. agonists.
therapeutic drug monitoring uses to determine the optimum dosage for a new c. neurotransmitters.
patient. d. null ligands.
a. body temperature Answer: a
b. urine testing Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions
c. brain scans
d. blood sampling 35. Both agonists and antagonists have but only agonists have appreciable
Answer: d .
Textbook Reference: Therapeutic Drug Monitoring a. interactions; affinity
b. affinity; bioavailability
30. While pharmacokinetics describes how the body deals with drugs, describes c. efficacy; affinity
how drug molecules interact with their targets. d. affinity; efficacy
a. drug effect Answer: d
b. pharmacodynamics Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions
c. antagonist action
d. agonist action 36. A dose–response curve shows that noncompetitive antagonists alter both the
Answer: b and the of the agonist, while competitive antagonists alter only the .
Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions a. potency; efficacy; potency
b. bioavailability; metabolism; bioavailability
31. In order for a drug to have an effect, it must first bind to a c. efficacy; potency; efficacy
a. ligand. d. depot binding; metabolism; metabolism
b. depot site. Answer: a
c. receptor. Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions
d. neurotransmitter.
Answer: c 37. In the dose–response curve, a decrease in potency is indicated by a shift
Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions a. to the left.
b. to the right.
32. Most drugs and neurotransmitters act upon c. upward.
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Test Bank
Psychopharmacology Drugs the Brain And Behavior 3rd Edition meyer Nursing
Test Bank
Test Bank
to accompany
Psychopharmacology, Third Edition
Meyer • Quenzer
Chapter 1: Principles of Pharmacology
Multiple Choice
1. refer(s) to specific molecular changes that occur when a drug binds to a
particular target site or receptor, while are the resulting widespread alterations
in function.
a. Drug action; therapeutic effects
b. Side effects; drug effects
c. Therapeutic effects; side effects
d. Drug action; drug effects
Answer: d
Textbook Reference: Pharmacology: The Science of Drug Action
2. After drug administration has occurred, the amount of drug in the blood that is free to
bind at specific target sites is referred to as
a. the therapeutic dose.
b. first-pass effects.
c. bioavailability.
d. ED50.
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
3. The specific molecular changes that occur when a drug binds to a particular target site
or receptor are referred to as
a. drug effects.
b. drug action.
c. side effects.
d. placebo effects.
Answer: b
Textbook Reference: Pharmacology: The Science of Drug Action
4. Which of the following is not a possible explanation for placebo effects?
a. Pavlovian conditioning
b. Genetic variation
c. Drug competition
d. Expectation of outcome
Answer: c
Textbook Reference: Pharmacology: The Science of Drug Action
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5. The administration of oxytocin has been proposed as a treatment for autism. Answer: c
a. intravenous Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b. oral
c. intranasal 11. Drugs administered _ have the most rapid onset of action.
d. intracerebral a. subcutaneously
Answer: c b. intramuscularly
Textbook Reference: Pharmacokinetic Factors Determining Drug Action c. orally
d. intravenously
6. Which factor does not affect the pharmacokinetics of a drug? Answer: d
a. Route of administration Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b. Lipid solubility
c. Depot binding 12. Ionization of a drug depends on the of the solution and the of the
d. Drug action drug.
Answer: d a. pH; pKa
Textbook Reference: Pharmacokinetic Factors Determining Drug Action b. pKa; pH
c. concentration; lipid solubility
7. First-pass metabolism occurs when drugs are taken d. pH; concentration
a. orally. Answer: a
b. intravenously. Textbook Reference: Pharmacokinetic Factors Determining Drug Action
c. subcutaneously.
d. nasally. 13. The absorption of a drug depends on all of the following except
Answer: a a. lipid solubility.
Textbook Reference: Pharmacokinetic Factors Determining Drug Action b. ionization.
c. body temperature.
8. The area postrema is one area in the brain where the is not complete. d. the concentration of the drug.
a. cerebrospinal fluid Answer: c
b. blood–brain barrier Textbook Reference: Pharmacokinetic Factors Determining Drug Action
c. choroid plexus
d. phospholipid membrane 14. Drugs that are should be avoided by women of childbearing age.
Answer: b a. teratogenic
Textbook Reference: Pharmacokinetic Factors Determining Drug Action b. able to cross the placental barrier
c. psychoactive
9. First-pass metabolism occurs with orally administered drugs because d. highly lipid-soluble
a. their absorption is slowed by food. Answer: a
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to Textbook Reference: Pharmacokinetic Factors Determining Drug Action
general circulation.
c. drugs must first survive the acidic environment of the stomach. 15. Agents that induce developmental abnormalities in a fetus are known as
d. salivary enzymes in the mouth begin the process of metabolism. a. psychoactive drugs.
Answer: b b. illicit drugs.
Textbook Reference: Pharmacokinetic Factors Determining Drug Action c. teratogens.
d. placental drugs.
10. Toxic substances in the blood trigger a vomiting response by activating the Answer: c
a. blood–brain barrier. Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b. choroid plexus.
c. area postrema. 16. Depot binding is said to occur when drugs
d. median eminence. a. bind to their target sites.
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b. bind to inactive sites. Answer: c
c. compete for binding sites. Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d. are excreted before binding.
Answer: b 22. Biotransformation of drugs can result in the formation of , which enter the
Textbook Reference: Pharmacokinetic Factors Determining Drug Action circulation and cause .
a. inactive metabolites; sensitization
17. Which statement about depot binding is false? b. active metabolites; prolonged drug action
a. It reduces the concentration of drug at its site of action. c. active metabolites; tolerance
b. It may delay the onset of drug action. d. enzymes; tolerance
c. It may prolong drug action by disrupting normal metabolism. Answer: b
d. It increases the concentration of drug at its site of action by releasing large quantities at Textbook Reference: Pharmacokinetic Factors Determining Drug Action
once.
Answer: d 23. Which statement about water-soluble metabolites formed in the liver is false?
Textbook Reference: Pharmacokinetic Factors Determining Drug Action a. They may return to the circulation and act on target tissues.
b. They may be filtered out by the kidneys.
18. Drug metabolism mostly occurs in the and usually makes a drug more c. They may be excreted into bile.
soluble. d. They may be eliminated with the feces.
a. kidneys; fat Answer: a
b. liver; fat Textbook Reference: Pharmacokinetic Factors Determining Drug Action
c. liver; water
d. kidneys; water 24. Which statement about microsomal enzymes in the liver is false?
Answer: c a. They are highly specific and act only on certain compounds.
Textbook Reference: Pharmacokinetic Factors Determining Drug Action b. They are located on the smooth endoplasmic reticulum.
c. The cytochrome P450 family is one of the most important.
19. Which statement about drug clearance by first-order kinetics is false? d. They can metabolize toxins and environmental pollutants as well as drugs.
a. Molecules of a drug are cleared at a constant rate regardless of drug concentration. Answer: a
b. Molecules of a drug are cleared at an exponential rate. Textbook Reference: Pharmacokinetic Factors Determining Drug Action
c. A constant fraction of the free drug in the blood is removed in each time interval.
d. Clearance of most drugs occurs in this manner. 25. Repeated use of many psychoactive drugs can cause , which can speed up the
Answer: a rate of biotransformation of these drugs as well as others.
Textbook Reference: Pharmacokinetic Factors Determining Drug Action a. drug competition
b. enzyme inhibition
20. Ethyl alcohol (ethanol) is an example of a drug that is eliminated c. enzyme induction
a. by first-order kinetics. d. tolerance
b. by zero-order kinetics. Answer: c
c. by second-order kinetics. Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d. at the point that six half-lives have passed.
Answer: b 26. Due to , antidepressants known as monoamine oxidase inhibitors (MAOIs)
Textbook Reference: Pharmacokinetic Factors Determining Drug Action can cause cardiac arrhythmias and high blood pressure in patients that consume foods
high in tyramine.
21. Biotransformation of drugs in the liver often occurs in two stages; phase I changes are a. sensitization
and include . b. tolerance
a. nonsynthetic; conjugation c. drug competition
b. synthetic; conjugation d. enzyme inhibition
c. nonsynthetic; oxidation Answer: d
d. synthetic; oxidation Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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a. intracellular receptors.
27. While drugs can be excreted from the body by several routes, the most important b. membrane-bound receptors.
route of elimination is through the c. protein synthesis.
a. breath. d. second messengers.
b. sweat. Answer: b
c. feces. Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions
d. urine.
Answer: d 33. While most receptors are membrane-bound on the cell surface, many
Textbook Reference: Pharmacokinetic Factors Determining Drug Action receptors are intracellular.
a. drug; neurotransmitter
28. The liver and kidneys work together to _ and drugs, respectively. b. hormone; drug
a. metabolize; excrete c. neurotransmitter; hormone
b. excrete; metabolize d. agonist; antagonist
c. bind; metabolize Answer: c
d. absorb; excrete Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions
Answer: a
Textbook Reference: Pharmacokinetic Factors Determining Drug Action 34. Ligands that have no effect on a receptor after binding are called
a. antagonists.
29. For drugs that have a narrow therapeutic window or potentially serious side effects, b. agonists.
therapeutic drug monitoring uses to determine the optimum dosage for a new c. neurotransmitters.
patient. d. null ligands.
a. body temperature Answer: a
b. urine testing Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions
c. brain scans
d. blood sampling 35. Both agonists and antagonists have but only agonists have appreciable
Answer: d .
Textbook Reference: Therapeutic Drug Monitoring a. interactions; affinity
b. affinity; bioavailability
30. While pharmacokinetics describes how the body deals with drugs, describes c. efficacy; affinity
how drug molecules interact with their targets. d. affinity; efficacy
a. drug effect Answer: d
b. pharmacodynamics Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions
c. antagonist action
d. agonist action 36. A dose–response curve shows that noncompetitive antagonists alter both the
Answer: b and the of the agonist, while competitive antagonists alter only the .
Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions a. potency; efficacy; potency
b. bioavailability; metabolism; bioavailability
31. In order for a drug to have an effect, it must first bind to a c. efficacy; potency; efficacy
a. ligand. d. depot binding; metabolism; metabolism
b. depot site. Answer: a
c. receptor. Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions
d. neurotransmitter.
Answer: c 37. In the dose–response curve, a decrease in potency is indicated by a shift
Textbook Reference: Pharmacodynamics: Drug–Receptor Interactions a. to the left.
b. to the right.
32. Most drugs and neurotransmitters act upon c. upward.
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