COMSAE-107, 2025 Simulated Exam COMSAE-107 2025
Simulated Exam: 100 High-Yield USMLE/COMLEX-Style
Questions with Answers and Rationales – Basic Sciences,
Clinical Medicine, and Osteopathic Principles Review
DMARD drug for UC/Crohns/RA - answer-:sulfasalazine
Sleep changes in depressed patients - answer-:decreased slow-wave sleep, decreased REM
latency, REM early in sleep cycle, increased total REM sleep, repeated nighttime awakenings,
early-morning awakenings
Cachexia mediated by - answer-:TNF-alpha, IFN-gamma, IL-6
Tx for Orotic aciduria - answer-:Uridine - inhibits carbamoyl phosphate synthetase
Short acting benzos - answer-:ATOM
Alprazolam, Triazolam, Oxazepam, Midazolam
Medium acting benzos - answer-:LET
Lorazepam, Estraolam, Temazepam
Long acting benzos - answer-:Clordiazepoxide, Clorazepate, Diazepam, Flurazepam
Climacteric period - answer-:Menopause
,Compartment syndrome d/t occlusion of: - answer-:Microvasculature (small arteries)
Grave's disease ab - answer-:anti-TSH
Addison's disease - answer-:Primary adrenal insufficiency d/t adrenal atrophy or destruction by
disease
hpL - answer-:human placental lactogen - increases insulin resistance, stimulates proteolysis
and lipolysis and inhibits gluconeogenesis --> hyperinsulin, hyperglycemia, hyperlipidemia
Hit in front or back of head - answer-:SBS compression
Hit under chin on same side - answer-:Torsion
Blow on side of head - answer-:Torsion strain
Hit on same side of head - answer-:Lateral strain
Hit on forehead at top of head - answer-:Superior strain
Hit at occiput - answer-:Inferior strain
Touch, pain, temp sensation from ipsilateral face - answer-:Spinal trigeminal nucleus
Ritodrine/Terbutaline - answer-:Beta 2 agonist that relzxes the uterus to reduce premature
uterine cotnractions; tocolytic
,"Ritodrine allows the fetus to return to dreams"
Ergonovine - answer-:to facilitate delivery of the placenta and to prevent bleeding after
childbirth by causing smooth muscle tissue in the blood vessel walls to narrow, thereby reducing
blood flow;
dx Prinzmental's angina
Metoclopramide - answer-:anti-emetic
Pyocyanin pigment - answer-:blue pigment - Pseudomonas
Sensorineural hearing loss, tinnitus, paralysis of facial muscles, loss of corneal reflex - answer-
:Cerebellopontine angle - b/w cerebellum and lateral pons; CNS 5, 7, 8
Hyperresonance - answer-:pneumothorax,
Large Q-waves - answer-:Old infarcts
Cachexia mediated by - answer-:TNF-alpha, IFN-gamma, IL-6
Tartrate resistant acid phosphatase positive in - answer-:Hairy Cell Leukemia
Low leukocyte ALP - answer-:CML
Cytosolic steroid receptor - answer-:VET CAP
Vitamin D, Estrogen, Testosterone, Cortisol, Aldosterone, Progesterone
, Nuclear steroid receptor - answer-:T3/T4
Tetanus tx - answer-:Tetanus antitoxin and tetanus toxoid series
Balantidium coli - answer-:protozoa found in pigs
Sumatriptan - answer-:5-HT 1B/1D agonist --> vasoconstsriction, inhibition of trigeminal
activation and vasoactive peptide release
Tx of S. pneumonia - answer-:Penicillin
Asthma drugs that cause tremors - answer-:Albuterol, Theophylline
Theophylline MOA - answer-:inhibits phosphodiesterease --> dec cAMP
Xenograft - answer-:from different species
syngeneic graft - answer-:from identical twin
Cyclophosphamide - answer-:alkylates DNA
maculopapular rash with pruritic lesions and an altered mental status - answer-:most likely
Rickettsia rickettsiae
What type of breathing will you see in DKA? - answer-:Kussmaul breathing
(hyperpnoea means increased depth and rate of breathing)
Simulated Exam: 100 High-Yield USMLE/COMLEX-Style
Questions with Answers and Rationales – Basic Sciences,
Clinical Medicine, and Osteopathic Principles Review
DMARD drug for UC/Crohns/RA - answer-:sulfasalazine
Sleep changes in depressed patients - answer-:decreased slow-wave sleep, decreased REM
latency, REM early in sleep cycle, increased total REM sleep, repeated nighttime awakenings,
early-morning awakenings
Cachexia mediated by - answer-:TNF-alpha, IFN-gamma, IL-6
Tx for Orotic aciduria - answer-:Uridine - inhibits carbamoyl phosphate synthetase
Short acting benzos - answer-:ATOM
Alprazolam, Triazolam, Oxazepam, Midazolam
Medium acting benzos - answer-:LET
Lorazepam, Estraolam, Temazepam
Long acting benzos - answer-:Clordiazepoxide, Clorazepate, Diazepam, Flurazepam
Climacteric period - answer-:Menopause
,Compartment syndrome d/t occlusion of: - answer-:Microvasculature (small arteries)
Grave's disease ab - answer-:anti-TSH
Addison's disease - answer-:Primary adrenal insufficiency d/t adrenal atrophy or destruction by
disease
hpL - answer-:human placental lactogen - increases insulin resistance, stimulates proteolysis
and lipolysis and inhibits gluconeogenesis --> hyperinsulin, hyperglycemia, hyperlipidemia
Hit in front or back of head - answer-:SBS compression
Hit under chin on same side - answer-:Torsion
Blow on side of head - answer-:Torsion strain
Hit on same side of head - answer-:Lateral strain
Hit on forehead at top of head - answer-:Superior strain
Hit at occiput - answer-:Inferior strain
Touch, pain, temp sensation from ipsilateral face - answer-:Spinal trigeminal nucleus
Ritodrine/Terbutaline - answer-:Beta 2 agonist that relzxes the uterus to reduce premature
uterine cotnractions; tocolytic
,"Ritodrine allows the fetus to return to dreams"
Ergonovine - answer-:to facilitate delivery of the placenta and to prevent bleeding after
childbirth by causing smooth muscle tissue in the blood vessel walls to narrow, thereby reducing
blood flow;
dx Prinzmental's angina
Metoclopramide - answer-:anti-emetic
Pyocyanin pigment - answer-:blue pigment - Pseudomonas
Sensorineural hearing loss, tinnitus, paralysis of facial muscles, loss of corneal reflex - answer-
:Cerebellopontine angle - b/w cerebellum and lateral pons; CNS 5, 7, 8
Hyperresonance - answer-:pneumothorax,
Large Q-waves - answer-:Old infarcts
Cachexia mediated by - answer-:TNF-alpha, IFN-gamma, IL-6
Tartrate resistant acid phosphatase positive in - answer-:Hairy Cell Leukemia
Low leukocyte ALP - answer-:CML
Cytosolic steroid receptor - answer-:VET CAP
Vitamin D, Estrogen, Testosterone, Cortisol, Aldosterone, Progesterone
, Nuclear steroid receptor - answer-:T3/T4
Tetanus tx - answer-:Tetanus antitoxin and tetanus toxoid series
Balantidium coli - answer-:protozoa found in pigs
Sumatriptan - answer-:5-HT 1B/1D agonist --> vasoconstsriction, inhibition of trigeminal
activation and vasoactive peptide release
Tx of S. pneumonia - answer-:Penicillin
Asthma drugs that cause tremors - answer-:Albuterol, Theophylline
Theophylline MOA - answer-:inhibits phosphodiesterease --> dec cAMP
Xenograft - answer-:from different species
syngeneic graft - answer-:from identical twin
Cyclophosphamide - answer-:alkylates DNA
maculopapular rash with pruritic lesions and an altered mental status - answer-:most likely
Rickettsia rickettsiae
What type of breathing will you see in DKA? - answer-:Kussmaul breathing
(hyperpnoea means increased depth and rate of breathing)
