PCB 3233 Exam 4 | Immunology
(Latest 2026/ 2027 Update) Review|
Questions & Answers |100% verified |
Grade A
Positive Selection
makes sure that your T-Cell recognizes one of your MHC.
If it does not, then apoptosis
Negative Selection
Makes sure it does not recognize your peptide:MHC too strongly
Does gamma: delta T-cells have to go through positive selection?
No
What does turning off RAG 1&2 do to your gene rearrangement?
Preserve the current rearrangement
Primary Lymphoid Tissue
bone marrow and thymus
, PCB 3233 Exam 4 | Immunology
(Latest 2026/ 2027 Update) Review|
Questions & Answers |100% verified |
Grade A
What does TH1 cells do?
Activate macrophages
Thymal Stromal Cells
Keeps BCR genes closed and opens TCR genes
IgM activates?
complement
Notch-1
The signal for survival. It drives the cell on the T-cell path — signals to open up T-cell
rearrangement.
Signaling rearrangement keeps T-cel on T-cell pathway
Where does Maturation and Positive Selection occur?
Cortex of the thymus
, PCB 3233 Exam 4 | Immunology
(Latest 2026/ 2027 Update) Review|
Questions & Answers |100% verified |
Grade A
Can negative selection also take place in the Cortex?
Yes, negative selection can take place in the cortex at the same time as positive selection
Where does negative selection take place?
medulla of thymus
Where are mature thymocytes located?
Medulla
Where are immature thymocytes located?
Cortex
What special cells are in the Medulla
Dendritic cells, macrophages, and medullary epithelial cells
What special cells are in the cortex?
, PCB 3233 Exam 4 | Immunology
(Latest 2026/ 2027 Update) Review|
Questions & Answers |100% verified |
Grade A
Cortical epithelial cells and macrophages
Where can you find AIRE?
in the medullary epithelial cells
AIRE
Autoimmune regulator
made by medullary epithelial cells
Creates a couple hundred peripheral peptides that can be used to test T-cells for negative
selection
DiGeorge's syndrome
deletion in chromosome 22 in which thymus fails to develop and T-cells are absent
Hassall's corpuscles
macrophages in both cortex and medulla remove the many thymocytes that fail to mature
properly
(Latest 2026/ 2027 Update) Review|
Questions & Answers |100% verified |
Grade A
Positive Selection
makes sure that your T-Cell recognizes one of your MHC.
If it does not, then apoptosis
Negative Selection
Makes sure it does not recognize your peptide:MHC too strongly
Does gamma: delta T-cells have to go through positive selection?
No
What does turning off RAG 1&2 do to your gene rearrangement?
Preserve the current rearrangement
Primary Lymphoid Tissue
bone marrow and thymus
, PCB 3233 Exam 4 | Immunology
(Latest 2026/ 2027 Update) Review|
Questions & Answers |100% verified |
Grade A
What does TH1 cells do?
Activate macrophages
Thymal Stromal Cells
Keeps BCR genes closed and opens TCR genes
IgM activates?
complement
Notch-1
The signal for survival. It drives the cell on the T-cell path — signals to open up T-cell
rearrangement.
Signaling rearrangement keeps T-cel on T-cell pathway
Where does Maturation and Positive Selection occur?
Cortex of the thymus
, PCB 3233 Exam 4 | Immunology
(Latest 2026/ 2027 Update) Review|
Questions & Answers |100% verified |
Grade A
Can negative selection also take place in the Cortex?
Yes, negative selection can take place in the cortex at the same time as positive selection
Where does negative selection take place?
medulla of thymus
Where are mature thymocytes located?
Medulla
Where are immature thymocytes located?
Cortex
What special cells are in the Medulla
Dendritic cells, macrophages, and medullary epithelial cells
What special cells are in the cortex?
, PCB 3233 Exam 4 | Immunology
(Latest 2026/ 2027 Update) Review|
Questions & Answers |100% verified |
Grade A
Cortical epithelial cells and macrophages
Where can you find AIRE?
in the medullary epithelial cells
AIRE
Autoimmune regulator
made by medullary epithelial cells
Creates a couple hundred peripheral peptides that can be used to test T-cells for negative
selection
DiGeorge's syndrome
deletion in chromosome 22 in which thymus fails to develop and T-cells are absent
Hassall's corpuscles
macrophages in both cortex and medulla remove the many thymocytes that fail to mature
properly
