PCB 3233 - FINAL EXAM QUESTIONS & ANSWERS
What are the primary adaptive immune cells? - Answer -B and T cells
What cells are lymphocytes? - Answer -NK, B, and T cells
What does the red pulp of the spleen do? - Answer -erythrocyte (RBC) filtration
What does the white pulp of the spleen do? - Answer -leukocyte (WBC) filtration
inactivation by Factor H and I results in an opsonin
-NOT a convertase
this is what C - Answer -ic3b
DAF stands for - Answer -decay accelerating factor
MCP stands for - Answer -membrane cofactor protein
inhibit the activity of bacterial proteases - Answer -alpha2-macroglobulins
are the human version of MAC complex, which creates pores/holes in pathogenic
surfaces - Answer -defensins
What cell makes up the highest concentration of leukocytes? - Answer -neutrophils
pus forming - Answer -pyogenic
fever inducing pyogenic or pyrogenic - Answer -pyrogenic
CR1 binds to - Answer -C3b
CR2 binds to - Answer -C3d
CR3 binds to - Answer -iC3b
CR4 binds to what on G bacteria - Answer -LPS on G- bacteria
TLR-3 binds to what virsus - Answer -dsRNA viruses
TLR-4 binds to what on bacteria - Answer -LPS on G- bacteria
TLR-5 binds to - Answer -Flagellin
,TLR-7 binds to virsus - Answer -ssRNA viruses
recognize bacterial cell components 2 N - Answer -NOD-1/NOD-2
a form of cytokine that directs leukocyte traff - Answer -chemokines
cytokines
proinflammotory
IL-1,2,3,4,5,6,7,8,9,10,11,12, CX, and T
name the 5 hint:IL-1 - Answer -proinflammatory mediators ( IL-1, IL-6, IL-12, CXCL8,
and TNF-alpha)
What cells are NOT in germline configuration? - Answer -mature B and mature T cells
-first Ab produced - Answer -IgM
Pentameric - Answer -IgM
activateis complement
which IG ? 2 - Answer -Igm IgG
can cross mucosal cell via polyg Ig recepor - Answer -IgM and dimeric IgA
-highest concentration in blood - Answer -IgG
-good for neutralization/opsonization - Answer -IgG
crosses placenta via the FcRn/FcRB/Brambell receptor - Answer -IgG
can be monomeric or dimeric
where are they found? - Answer -IgA
monomeric=circulation
dimeric=gut
-most abundant in the body
which Ig - Answer -IgA
-involved in allergic reactions and parasites - Answer -IgE
-present in serum in low levels: IgG,A,M,E - Answer -IgE
, high affinity for FCeRII found on mast cells, basophils, and activated eosinophils -
Answer -IgE
-found on the surface of mature, naive B cells (along with IgM) - Answer -IgD
-complementary determining region and hypervariable loop are synonymous - Answer -
CDR-X/HV-X
What is the most diverse CDR and HV? - Answer -CDR3/HV3
Somatic recombination occurs in what2 lymphotcyes? - Answer -B and T lymphocytes
Somatic hypermutation occurs in what lymphoctye? - Answer -B lymphocytes
recombination signal sequences are the "launching pad" for RAG-1 and RAG-2 during
somatic recombination - Answer -RSS
12/23 or 1/2 turn rule - Answer -one RAG complex binds to a 23bp spacer (2 turns)
while another RAG complex binds to a 12bp spacer (1 turn) and they are brought
together
-terminal deoxynucleotidyl transferase
-adds N nucleotides to generate junctional diversity - Answer -TdT
Heavy chain (B cell) and
beta chain (T cell) rearrangement - Answer --D→ J
-DJ→ V
What are the different isotypes of heavy chain?
GAMED - Answer --Alpha: 1 and 2
-Delta
-Gamma: 1, 2, 3, 4
-Epsilon
-Mu
Light chain (B cell)
and alpha chain (T cell) rearrangement - Answer -V→ J
What are the different isotypes of light chain? - Answer --Kappa
-Lambda
What is the goal of somatic hypermutation?
increase what?
by rearranging what regions - Answer -While in a germinal center located inside of a
secondary lymphoid tissue, to increase affinity of B lymphocytes by rearranging the V
regions
What are the primary adaptive immune cells? - Answer -B and T cells
What cells are lymphocytes? - Answer -NK, B, and T cells
What does the red pulp of the spleen do? - Answer -erythrocyte (RBC) filtration
What does the white pulp of the spleen do? - Answer -leukocyte (WBC) filtration
inactivation by Factor H and I results in an opsonin
-NOT a convertase
this is what C - Answer -ic3b
DAF stands for - Answer -decay accelerating factor
MCP stands for - Answer -membrane cofactor protein
inhibit the activity of bacterial proteases - Answer -alpha2-macroglobulins
are the human version of MAC complex, which creates pores/holes in pathogenic
surfaces - Answer -defensins
What cell makes up the highest concentration of leukocytes? - Answer -neutrophils
pus forming - Answer -pyogenic
fever inducing pyogenic or pyrogenic - Answer -pyrogenic
CR1 binds to - Answer -C3b
CR2 binds to - Answer -C3d
CR3 binds to - Answer -iC3b
CR4 binds to what on G bacteria - Answer -LPS on G- bacteria
TLR-3 binds to what virsus - Answer -dsRNA viruses
TLR-4 binds to what on bacteria - Answer -LPS on G- bacteria
TLR-5 binds to - Answer -Flagellin
,TLR-7 binds to virsus - Answer -ssRNA viruses
recognize bacterial cell components 2 N - Answer -NOD-1/NOD-2
a form of cytokine that directs leukocyte traff - Answer -chemokines
cytokines
proinflammotory
IL-1,2,3,4,5,6,7,8,9,10,11,12, CX, and T
name the 5 hint:IL-1 - Answer -proinflammatory mediators ( IL-1, IL-6, IL-12, CXCL8,
and TNF-alpha)
What cells are NOT in germline configuration? - Answer -mature B and mature T cells
-first Ab produced - Answer -IgM
Pentameric - Answer -IgM
activateis complement
which IG ? 2 - Answer -Igm IgG
can cross mucosal cell via polyg Ig recepor - Answer -IgM and dimeric IgA
-highest concentration in blood - Answer -IgG
-good for neutralization/opsonization - Answer -IgG
crosses placenta via the FcRn/FcRB/Brambell receptor - Answer -IgG
can be monomeric or dimeric
where are they found? - Answer -IgA
monomeric=circulation
dimeric=gut
-most abundant in the body
which Ig - Answer -IgA
-involved in allergic reactions and parasites - Answer -IgE
-present in serum in low levels: IgG,A,M,E - Answer -IgE
, high affinity for FCeRII found on mast cells, basophils, and activated eosinophils -
Answer -IgE
-found on the surface of mature, naive B cells (along with IgM) - Answer -IgD
-complementary determining region and hypervariable loop are synonymous - Answer -
CDR-X/HV-X
What is the most diverse CDR and HV? - Answer -CDR3/HV3
Somatic recombination occurs in what2 lymphotcyes? - Answer -B and T lymphocytes
Somatic hypermutation occurs in what lymphoctye? - Answer -B lymphocytes
recombination signal sequences are the "launching pad" for RAG-1 and RAG-2 during
somatic recombination - Answer -RSS
12/23 or 1/2 turn rule - Answer -one RAG complex binds to a 23bp spacer (2 turns)
while another RAG complex binds to a 12bp spacer (1 turn) and they are brought
together
-terminal deoxynucleotidyl transferase
-adds N nucleotides to generate junctional diversity - Answer -TdT
Heavy chain (B cell) and
beta chain (T cell) rearrangement - Answer --D→ J
-DJ→ V
What are the different isotypes of heavy chain?
GAMED - Answer --Alpha: 1 and 2
-Delta
-Gamma: 1, 2, 3, 4
-Epsilon
-Mu
Light chain (B cell)
and alpha chain (T cell) rearrangement - Answer -V→ J
What are the different isotypes of light chain? - Answer --Kappa
-Lambda
What is the goal of somatic hypermutation?
increase what?
by rearranging what regions - Answer -While in a germinal center located inside of a
secondary lymphoid tissue, to increase affinity of B lymphocytes by rearranging the V
regions
