NBME 25 EXAM 2025/2026 QUESTIONS
AND ANSWERS 100% PASS
Large pressure gradient between left ventricle and aorta during systole - ANS aortic stenosis
(calcification)
Hyperacute transplant rejection is what type of hypersensitivty rxn - ANS type 2 - pre
existant recipient antibodies react to donor antigen
acute transplant rejection is what type of hypersensitivity rxn - ANS type 4- T cell mediated
OR
humoral: similar to hyperacute except antibodies form after transplant
which type of transplant rejection is both type 2 and type 4 hypersens - ANS chronic
Grafted immunocompetent T Cells proliferate in the immunocompromised host and reject host
cells with 'foreign' proteins. Severe organ dysfunction - ANS graft-versus-host disease
which type of transplant rejection is dominated by arteriosclerosis - ANS chronic
you have to test for Hep B prior to giving someone what monoclonal antibody -
ANS rituximab
1 @COPYRIGHT 2025/2026
, vitamin D binds what type of receptor (location) - ANS nuclear
you can find 2 forms of vitamin D in foods and skin. what are they - ANS 1. cholecalciferol
2. ergocalciferol
once ingesting either chole or erocalciferol, where do they go? - ANS to the liver to be
converted to 25-hydroxyvitamin D
25-hydroxyvitamin D is formed in the - ANS liver
what converts 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D - ANS 1-alpha-hydroxylase in
the kidney
calcitriol is the - ANS active form of Vitamin D
mutation inactivating the Vitamin D receptor effects on: vitamin D conc, calcium -
ANS vitamin D: normal
calcium: low
non healing ulcerative lesion with scale - ANS SCC of the skin
renal cell carcinoma is an adenocarcinoma of - ANS tubular epithelial cells
polycythemia, hypercalcemia, likes to metastisze to the brain or lungs, microscopic hematuria,
smoking, male - ANS renal cell carcinoma
CEA marker - ANS colon cancer
AFP is elevated in what cancer - ANS hepatocellular
2 @COPYRIGHT 2025/2026
AND ANSWERS 100% PASS
Large pressure gradient between left ventricle and aorta during systole - ANS aortic stenosis
(calcification)
Hyperacute transplant rejection is what type of hypersensitivty rxn - ANS type 2 - pre
existant recipient antibodies react to donor antigen
acute transplant rejection is what type of hypersensitivity rxn - ANS type 4- T cell mediated
OR
humoral: similar to hyperacute except antibodies form after transplant
which type of transplant rejection is both type 2 and type 4 hypersens - ANS chronic
Grafted immunocompetent T Cells proliferate in the immunocompromised host and reject host
cells with 'foreign' proteins. Severe organ dysfunction - ANS graft-versus-host disease
which type of transplant rejection is dominated by arteriosclerosis - ANS chronic
you have to test for Hep B prior to giving someone what monoclonal antibody -
ANS rituximab
1 @COPYRIGHT 2025/2026
, vitamin D binds what type of receptor (location) - ANS nuclear
you can find 2 forms of vitamin D in foods and skin. what are they - ANS 1. cholecalciferol
2. ergocalciferol
once ingesting either chole or erocalciferol, where do they go? - ANS to the liver to be
converted to 25-hydroxyvitamin D
25-hydroxyvitamin D is formed in the - ANS liver
what converts 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D - ANS 1-alpha-hydroxylase in
the kidney
calcitriol is the - ANS active form of Vitamin D
mutation inactivating the Vitamin D receptor effects on: vitamin D conc, calcium -
ANS vitamin D: normal
calcium: low
non healing ulcerative lesion with scale - ANS SCC of the skin
renal cell carcinoma is an adenocarcinoma of - ANS tubular epithelial cells
polycythemia, hypercalcemia, likes to metastisze to the brain or lungs, microscopic hematuria,
smoking, male - ANS renal cell carcinoma
CEA marker - ANS colon cancer
AFP is elevated in what cancer - ANS hepatocellular
2 @COPYRIGHT 2025/2026
